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Neonatal asphyxia

MedGen UID:
2469
•Concept ID:
C0004045
•
Disease or Syndrome
Synonyms: Asphyxia neonatorum; Asphyxia, in liveborn infant; Birth asphyxia; Hypoxia neonatorum; Postnatal asphyxia
SNOMED CT: Birth asphyxia (413654009); Asphyxia in liveborn infant (28314004); Neonatal asphyxia (28314004); Intrapartum fetal asphyxia (28314004); Asphyxia neonatorum (28314004); Intrapartum asphyxia (28314004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
HPO: HP:0012768
Monarch Initiative: MONDO:0006663
Orphanet: ORPHA137577

Definition

Respiratory failure in the newborn. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Neonatal asphyxia

Conditions with this feature

Ichthyosis prematurity syndrome
MedGen UID:
324839
•Concept ID:
C1837610
•
Disease or Syndrome
Ichthyosis prematurity syndrome (IPS) is a rare subtype of autosomal recessive congenital ichthyosis, a clinically and genetically heterogeneous group of inherited keratinization disorders. IPS presents with complications at midtrimester of pregnancy leading to prematurity, a thick caseous and desquamating skin, respiratory complications, and persistent eosinophilia. Skin features evolve into a flat follicular hyperkeratosis with atopy (Klar et al., 2004).
See: Condition Record
COG7 congenital disorder of glycosylation
MedGen UID:
419311
•Concept ID:
C2931010
•
Disease or Syndrome
CDG IIe is caused by a mutation that impairs the integrity of the conserved oligomeric Golgi (COG) complex and alters Golgi trafficking, resulting in the disruption of multiple glycosylation pathways. For a general discussion of CDGs, see CDG1A (212065).
See: Condition Record
COG7 congenital disorder of glycosylation
Ichthyosis prematurity syndrome

Professional guidelines

PubMed

Clinical efficacy of low-dose dopamine in the treatment of renal injury after neonatal asphyxia and evaluation of renal function improvement.
Yang Z, Geng W, Hei M
Minerva Pediatr (Torino) 2022 Apr;74(2):232-234. Epub 2021 Sep 30 doi: 10.23736/S2724-5276.21.06630-1. PMID: 34590808
Management of neonatal asphyxia.
Hein HA
JAMA 1980 Jun 27;243(24):2482-3. PMID: 7382029
Neonatal asphyxia. An approach to physiology and management.
Dorand RD
Pediatr Clin North Am 1977 Aug;24(3):455-61. doi: 10.1016/s0031-3955(16)33456-3. PMID: 408781

Recent clinical studies

Etiology

Induction of labour at or near term for suspected fetal macrosomia.
Boulvain M, Thornton JG
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD000938. doi: 10.1002/14651858.CD000938.pub3. PMID: 36884238Free PMC Article
Analysis of closely related risk factors and preventive measures of neonatal asphyxia.
Kong D, Du Y, Wang X, Kong D, Chen H, Ge Y, Qiang Y
Minerva Pediatr (Torino) 2022 Oct;74(5):624-626. Epub 2022 May 5 doi: 10.23736/S2724-5276.22.06916-6. PMID: 35511678
The role of magnesium sulfate (MgSO(4)) in fetal neuroprotection.
Bachnas MA, Akbar MIA, Dachlan EG, Dekker G
J Matern Fetal Neonatal Med 2021 Mar;34(6):966-978. Epub 2019 May 27 doi: 10.1080/14767058.2019.1619688. PMID: 31092073
Therapeutic hypothermia.
Alzaga AG, Cerdan M, Varon J
Resuscitation 2006 Sep;70(3):369-80. Epub 2006 Aug 22 doi: 10.1016/j.resuscitation.2006.01.017. PMID: 16930801
Parity and pre-eclampsia.
Long PA, Abell DA, Beischer NA
Aust N Z J Obstet Gynaecol 1979 Nov;19(4):203-6. doi: 10.1111/j.1479-828x.1979.tb01373.x. PMID: 295636

Diagnosis

Induction of labour at or near term for suspected fetal macrosomia.
Boulvain M, Thornton JG
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD000938. doi: 10.1002/14651858.CD000938.pub3. PMID: 36884238Free PMC Article
Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children.
Riikonen R
Int J Mol Sci 2017 Sep 26;18(10) doi: 10.3390/ijms18102056. PMID: 28954393Free PMC Article
Acute kidney injury post neonatal asphyxia.
Durkan AM, Alexander RT
J Pediatr 2011 Feb;158(2 Suppl):e29-33. doi: 10.1016/j.jpeds.2010.11.010. PMID: 21238703
S100B protein related neonatal hypoxia.
Martins RO, Rotta NT, Portela LV, Souza DO
Arq Neuropsiquiatr 2006 Mar;64(1):24-9. Epub 2006 Apr 5 doi: 10.1590/s0004-282x2006000100006. PMID: 16622548
Neonatal asphyxia, definitive markers and hearing loss.
Mencher LS, Mencher GT
Audiology 1999 Nov-Dec;38(6):291-5. doi: 10.3109/00206099909073038. PMID: 10582528

Therapy

Hypoxic-Ischemic Encephalopathy: Pathogenesis and Promising Therapies.
Yang M, Wang K, Liu B, Shen Y, Liu G
Mol Neurobiol 2025 Feb;62(2):2105-2122. Epub 2024 Jul 29 doi: 10.1007/s12035-024-04398-9. PMID: 39073530
Induction of labour at or near term for suspected fetal macrosomia.
Boulvain M, Thornton JG
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD000938. doi: 10.1002/14651858.CD000938.pub3. PMID: 36884238Free PMC Article
Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis.
Yin J, Mei Z, Shi S, Du P, Qin S
Arch Gynecol Obstet 2022 Dec;306(6):1891-1900. Epub 2022 Mar 19 doi: 10.1007/s00404-022-06504-5. PMID: 35305140
The role of magnesium sulfate (MgSO(4)) in fetal neuroprotection.
Bachnas MA, Akbar MIA, Dachlan EG, Dekker G
J Matern Fetal Neonatal Med 2021 Mar;34(6):966-978. Epub 2019 May 27 doi: 10.1080/14767058.2019.1619688. PMID: 31092073
Insulin-Like Growth Factors in the Pathogenesis of Neurological Diseases in Children.
Riikonen R
Int J Mol Sci 2017 Sep 26;18(10) doi: 10.3390/ijms18102056. PMID: 28954393Free PMC Article

Prognosis

Heart rate variability and inflammatory markers in neonates with hypoxic-ischemic encephalopathy.
Yasova Barbeau D, Krueger C, Huene M, Copenhaver N, Bennett J, Weaver M, Weiss MD
Physiol Rep 2019 Aug;7(15):e14110. doi: 10.14814/phy2.14110. PMID: 31397094Free PMC Article
State of the Art on Kidney Development: How Nephron Endowment at Birth Can Shape Our Susceptibility to Renal Dysfunction Later in Life.
Fanos V, Gerosa C, Loddo C, Faa G
Am J Perinatol 2019 Jul;36(S 02):S33-S36. Epub 2019 Jun 25 doi: 10.1055/s-0039-1691798. PMID: 31238356
Acute kidney injury post neonatal asphyxia.
Durkan AM, Alexander RT
J Pediatr 2011 Feb;158(2 Suppl):e29-33. doi: 10.1016/j.jpeds.2010.11.010. PMID: 21238703
Neonatal asphyxia, definitive markers and hearing loss.
Mencher LS, Mencher GT
Audiology 1999 Nov-Dec;38(6):291-5. doi: 10.3109/00206099909073038. PMID: 10582528
Parity and pre-eclampsia.
Long PA, Abell DA, Beischer NA
Aust N Z J Obstet Gynaecol 1979 Nov;19(4):203-6. doi: 10.1111/j.1479-828x.1979.tb01373.x. PMID: 295636

Clinical prediction guides

Induction of labour at or near term for suspected fetal macrosomia.
Boulvain M, Thornton JG
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD000938. doi: 10.1002/14651858.CD000938.pub3. PMID: 36884238Free PMC Article
The Effects of Acidosis on eNOS in the Systemic Vasculature: A Focus on Early Postnatal Ontogenesis.
Gaynullina DK, Tarasova OS, Shvetsova AA, Borzykh AA, Schubert R
Int J Mol Sci 2022 May 26;23(11) doi: 10.3390/ijms23115987. PMID: 35682667Free PMC Article
Heart rate variability and inflammatory markers in neonates with hypoxic-ischemic encephalopathy.
Yasova Barbeau D, Krueger C, Huene M, Copenhaver N, Bennett J, Weaver M, Weiss MD
Physiol Rep 2019 Aug;7(15):e14110. doi: 10.14814/phy2.14110. PMID: 31397094Free PMC Article
Neonatal asphyxia, definitive markers and hearing loss.
Mencher LS, Mencher GT
Audiology 1999 Nov-Dec;38(6):291-5. doi: 10.3109/00206099909073038. PMID: 10582528
Severe neonatal asphyxia. Incidence and prediction of outcome in the Stockholm area.
Ergander U, Eriksson M, Zetterström R
Acta Paediatr Scand 1983 May;72(3):321-5. doi: 10.1111/j.1651-2227.1983.tb09722.x. PMID: 6880716

Recent systematic reviews

The safety of trial of labor after cesarean section (TOLAC) versus elective repeat cesarean section (ERCS): a systematic review and meta-analysis.
Qiu L, Zhu J, Lu X
J Matern Fetal Neonatal Med 2023 Dec;36(1):2214831. doi: 10.1080/14767058.2023.2214831. PMID: 37217450
Induction of labour at or near term for suspected fetal macrosomia.
Boulvain M, Thornton JG
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD000938. doi: 10.1002/14651858.CD000938.pub3. PMID: 36884238Free PMC Article
Nifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis.
Yin J, Mei Z, Shi S, Du P, Qin S
Arch Gynecol Obstet 2022 Dec;306(6):1891-1900. Epub 2022 Mar 19 doi: 10.1007/s00404-022-06504-5. PMID: 35305140
Pregnancy and COVID-19: a systematic review of maternal, obstetric and neonatal outcomes.
Trocado V, Silvestre-Machado J, Azevedo L, Miranda A, Nogueira-Silva C
J Matern Fetal Neonatal Med 2022 Jun;35(12):2362-2374. Epub 2020 Jul 7 doi: 10.1080/14767058.2020.1781809. PMID: 32635775
Coronavirus disease 2019 (COVID-19) and pregnancy: a systematic review.
Yang Z, Wang M, Zhu Z, Liu Y
J Matern Fetal Neonatal Med 2022 Apr;35(8):1619-1622. Epub 2020 Apr 30 doi: 10.1080/14767058.2020.1759541. PMID: 32354293

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