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Acute disseminated intravascular coagulation

MedGen UID:
868744
•Concept ID:
C4023149
•
Disease or Syndrome
HPO: HP:0011880

Definition

An acute form of disseminated intravascular coagulation. Acute DIC can occur following sudden exposure of blood to procoagulants, with the compensatory hemostatic mechanisms becoming overwhelmed. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAcute disseminated intravascular coagulation

Professional guidelines

PubMed

Acute disseminated intravascular coagulation secondary to (177)Lu-DOTATATE treatment in neuroendocrine tumor patients.
Illia MF, Greco M, Cosacow C, Sahar J, Rivero Equiza T, Fernández J, Bastianello MJ
Rev Esp Med Nucl Imagen Mol (Engl Ed) 2023 Jan-Feb;42(1):67-68. Epub 2022 Dec 10 doi: 10.1016/j.remnie.2022.09.014. PMID: 36513327
Practice Bulletin No. 183: Postpartum Hemorrhage.
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2017 Oct;130(4):e168-e186. doi: 10.1097/AOG.0000000000002351. PMID: 28937571
UK malaria treatment guidelines 2016.
Lalloo DG, Shingadia D, Bell DJ, Beeching NJ, Whitty CJM, Chiodini PL; PHE Advisory Committee on Malaria Prevention in UK Travellers
J Infect 2016 Jun;72(6):635-649. Epub 2016 Feb 12 doi: 10.1016/j.jinf.2016.02.001. PMID: 26880088Free PMC Article

Recent clinical studies

Etiology

Management of heparin-induced thrombocytopenia.
Warkentin TE, Greinacher A
Curr Opin Hematol 2016 Sep;23(5):462-70. doi: 10.1097/MOH.0000000000000273. PMID: 27380556
Coagulopathy of Acute Sepsis.
Semeraro N, Ammollo CT, Semeraro F, Colucci M
Semin Thromb Hemost 2015 Sep;41(6):650-8. Epub 2015 Aug 25 doi: 10.1055/s-0035-1556730. PMID: 26305237
Heparin-induced thrombocytopenia in critically ill patients.
Warkentin TE
Semin Thromb Hemost 2015 Feb;41(1):49-60. Epub 2015 Jan 15 doi: 10.1055/s-0034-1398381. PMID: 25590528
Coagulation abnormalities in sepsis.
Tsao CM, Ho ST, Wu CC
Acta Anaesthesiol Taiwan 2015 Mar;53(1):16-22. Epub 2014 Dec 26 doi: 10.1016/j.aat.2014.11.002. PMID: 25544351
Sepsis, thrombosis and organ dysfunction.
Semeraro N, Ammollo CT, Semeraro F, Colucci M
Thromb Res 2012 Mar;129(3):290-5. Epub 2011 Nov 5 doi: 10.1016/j.thromres.2011.10.013. PMID: 22061311

Diagnosis

Acute Disseminated Intravascular Coagulation Precipitated by (177)Lu-Dotatate in Metastatic Midgut Neuroendocrine Tumor: A Case Report.
Fiocco C, Farooq F, Kaveney A
J Gastrointest Cancer 2023 Dec;54(4):1370-1372. Epub 2023 Feb 16 doi: 10.1007/s12029-023-00918-3. PMID: 36795338
Management of heparin-induced thrombocytopenia.
Warkentin TE, Greinacher A
Curr Opin Hematol 2016 Sep;23(5):462-70. doi: 10.1097/MOH.0000000000000273. PMID: 27380556
Coagulation abnormalities in sepsis.
Tsao CM, Ho ST, Wu CC
Acta Anaesthesiol Taiwan 2015 Mar;53(1):16-22. Epub 2014 Dec 26 doi: 10.1016/j.aat.2014.11.002. PMID: 25544351
Extensive cerebral microhemorrhages caused by acute disseminated intravascular coagulation secondary to sepsis.
Neligan A, Rajakulendran S, Nortley R, Manji H
JAMA Neurol 2014 Apr;71(4):510-1. doi: 10.1001/jamaneurol.2013.223. PMID: 24566732
Acute disseminated intravascular coagulation.
Franco LM
Crit Care Update 1981 Jan;8(1):17-20. PMID: 6904272

Therapy

Acute Disseminated Intravascular Coagulation Precipitated by (177)Lu-Dotatate in Metastatic Midgut Neuroendocrine Tumor: A Case Report.
Fiocco C, Farooq F, Kaveney A
J Gastrointest Cancer 2023 Dec;54(4):1370-1372. Epub 2023 Feb 16 doi: 10.1007/s12029-023-00918-3. PMID: 36795338
Management of heparin-induced thrombocytopenia.
Warkentin TE, Greinacher A
Curr Opin Hematol 2016 Sep;23(5):462-70. doi: 10.1097/MOH.0000000000000273. PMID: 27380556
Coagulation abnormalities in sepsis.
Tsao CM, Ho ST, Wu CC
Acta Anaesthesiol Taiwan 2015 Mar;53(1):16-22. Epub 2014 Dec 26 doi: 10.1016/j.aat.2014.11.002. PMID: 25544351
Acute disseminated intravascular coagulation.
Franco LM
Crit Care Update 1981 Jan;8(1):17-20. PMID: 6904272
Severe, acute disseminated intravascular coagulation. A reappraisal of its pathophysiology, clinical significance and therapy based on 47 patients.
Mant MJ, King EG
Am J Med 1979 Oct;67(4):557-63. doi: 10.1016/0002-9343(79)90225-0. PMID: 495626

Prognosis

Combination of dirty mass volume and APACHE II score predicts mortality in patients with colorectal perforation.
Ishikawa D, Takehara Y, Takata A, Takamura K, Sato H
World J Emerg Surg 2021 Mar 30;16(1):17. doi: 10.1186/s13017-021-00359-y. PMID: 33785047Free PMC Article
Acute Disseminated Intravascular Coagulation after Oxaliplatin Infusion.
Waddle M, Irvin M, Gupta E, Gibbs M, Kakar TS, Gannon NA, Arthurs JR, Fischer DL, Ailawadhi S
Chemotherapy 2017;62(5):295-300. Epub 2017 May 16 doi: 10.1159/000471844. PMID: 28505615
Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009).
Rattray DD, O'Connell CM, Baskett TF
J Obstet Gynaecol Can 2012 Apr;34(4):341-347. doi: 10.1016/S1701-2163(16)35214-8. PMID: 22472333
The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients.
Hook KM, Abrams CS
Clin Transl Sci 2012 Feb;5(1):85-92. Epub 2011 Dec 7 doi: 10.1111/j.1752-8062.2011.00351.x. PMID: 22376264Free PMC Article
Fatality from disseminated intravascular coagulation complicating total hip arthroplasty: a case report.
Sporer SM, Callaghan JJ
Iowa Orthop J 1997;17:53-7. PMID: 9234974Free PMC Article

Clinical prediction guides

Factors associated with mortality in patients with extremity necrotizing soft-tissue infections: a single academic center experience.
Nagira K, Ogoshi T, Akahori K, Enokida S, Enokida M, Ueda T, Homma M, Nagashima H
Langenbecks Arch Surg 2023 May 11;408(1):189. doi: 10.1007/s00423-023-02929-x. PMID: 37166568
Antithrombin as Therapeutic Intervention against Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation: Lessons Learned from COVID-19-Associated Coagulopathy.
Wiedermann CJ
Int J Mol Sci 2022 Oct 18;23(20) doi: 10.3390/ijms232012474. PMID: 36293332Free PMC Article
Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives.
Sengupta T, Majumder R, Majumder S
Mol Cell Biochem 2021 Jun;476(6):2421-2427. Epub 2021 Feb 18 doi: 10.1007/s11010-021-04093-6. PMID: 33604809Free PMC Article
Acute disseminated intravascular coagulation in obstetrics: a tertiary centre population review (1980 to 2009).
Rattray DD, O'Connell CM, Baskett TF
J Obstet Gynaecol Can 2012 Apr;34(4):341-347. doi: 10.1016/S1701-2163(16)35214-8. PMID: 22472333
The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients.
Hook KM, Abrams CS
Clin Transl Sci 2012 Feb;5(1):85-92. Epub 2011 Dec 7 doi: 10.1111/j.1752-8062.2011.00351.x. PMID: 22376264Free PMC Article

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