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Benign connective and soft tissue neoplasm

MedGen UID:
83866
•Concept ID:
C0347481
•
Neoplastic Process
Synonyms: Benign Connective and Soft Tissue Neoplasm; benign connective and soft tissue neoplasm; Benign Connective and Soft Tissue Tumor; benign connective and soft tissue tumor; benign connective and soft tissue tumour; Benign Mesenchymal Cell Neoplasm; benign mesenchymal cell neoplasm; Benign Neoplasm of the Soft Tissue and Bone; benign neoplasm of the soft tissue and bone; Benign Tumor of the Soft Tissue and Bone; benign tumor of the soft tissue and bone; benign tumour of the soft tissue and bone; connective and soft tissue neoplasm, benign; connective tissue benign neoplasm; neoplasm of soft tissue; neoplasm of soft tissues; soft tissue benign neoplasm; tumor of the soft tissue; tumour of the soft tissue
 
Monarch Initiative: MONDO:0000654

Definition

A neoplasm that arises from connective and soft tissue and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include lipoma, leiomyoma, fibroma, and osteoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign connective and soft tissue neoplasm

Professional guidelines

PubMed

ACG Clinical Guideline: Diagnosis and Management of Gastrointestinal Subepithelial Lesions.
Jacobson BC, Bhatt A, Greer KB, Lee LS, Park WG, Sauer BG, Shami VM
Am J Gastroenterol 2023 Jan 1;118(1):46-58. Epub 2022 Sep 6 doi: 10.14309/ajg.0000000000002100. PMID: 36602835
EAA clinical practice guidelines-gynecomastia evaluation and management.
Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N
Andrology 2019 Nov;7(6):778-793. Epub 2019 May 16 doi: 10.1111/andr.12636. PMID: 31099174
Uterine Fibroids: Diagnosis and Treatment.
De La Cruz MS, Buchanan EM
Am Fam Physician 2017 Jan 15;95(2):100-107. PMID: 28084714

Recent clinical studies

Etiology

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
A Diagnostic Approach to Fibroepithelial Breast Lesions.
Tan BY, Tan PH
Surg Pathol Clin 2018 Mar;11(1):17-42. Epub 2017 Dec 1 doi: 10.1016/j.path.2017.09.003. PMID: 29413655
Cartilage-forming tumors.
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178
Lipoma excision.
Salam GA
Am Fam Physician 2002 Mar 1;65(5):901-4. PMID: 11898962
Fibrous histiocytoma.
Krohel GB, Gregor Z
J Pediatr Ophthalmol Strabismus 1980 Jan-Feb;17(1):37-9. doi: 10.3928/0191-3913-19800101-09. PMID: 6245201

Diagnosis

Lipoma and Its Doppelganger: The Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma.
Yee EJ, Stewart CL, Clay MR, McCarter MM
Surg Clin North Am 2022 Aug;102(4):637-656. doi: 10.1016/j.suc.2022.04.006. PMID: 35952693
Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Cartilage-forming tumors.
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178
Lipoma excision.
Salam GA
Am Fam Physician 2002 Mar 1;65(5):901-4. PMID: 11898962
PSEUDOSARCOMATOUS DERMATOFIBROMA.
LEVAN NE, HIRSCH P, KWONG MQ
Arch Dermatol 1963 Dec;88:908-12. doi: 10.1001/archderm.1963.01590240232038. PMID: 14071469

Therapy

Tenosynovial giant cell tumor.
Kager M, Kager R, Fałek P, Fałek A, Szczypiór G, Niemunis-Sawicka J, Rzepecka-Wejs L, Starosławska E, Burdan F
Folia Med Cracov 2022;62(2):93-107. doi: 10.24425/fmc.2022.141702. PMID: 36256897
High-intensity focused ultrasound therapy.
Cheung VYT
Best Pract Res Clin Obstet Gynaecol 2018 Jan;46:74-83. Epub 2017 Oct 3 doi: 10.1016/j.bpobgyn.2017.09.002. PMID: 29074037
Benign Metastasizing Leiomyoma.
Pacheco-Rodriguez G, Taveira-DaSilva AM, Moss J
Clin Chest Med 2016 Sep;37(3):589-95. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.019. PMID: 27514603
Uterine fibroid management: from the present to the future.
Donnez J, Dolmans MM
Hum Reprod Update 2016 Nov;22(6):665-686. Epub 2016 Jul 27 doi: 10.1093/humupd/dmw023. PMID: 27466209Free PMC Article
Dupuytren's disease.
Worrell M
Orthopedics 2012 Jan;35(1):52-60. doi: 10.3928/01477447-20111122-23. PMID: 22229922

Prognosis

Current clinical management of primary cardiac sarcoma.
Siontis BL, Leja M, Chugh R
Expert Rev Anticancer Ther 2020 Jan;20(1):45-51. Epub 2020 Jan 9 doi: 10.1080/14737140.2020.1711738. PMID: 31914831
Lipomatous Soft-tissue Tumors.
Johnson CN, Ha AS, Chen E, Davidson D
J Am Acad Orthop Surg 2018 Nov 15;26(22):779-788. doi: 10.5435/JAAOS-D-17-00045. PMID: 30192249
Solitary fibrous tumours of the pleura.
Abu Arab W
Eur J Cardiothorac Surg 2012 Mar;41(3):587-97. Epub 2011 Oct 20 doi: 10.1093/ejcts/ezr009. PMID: 22345180
Sarcomas of the kidney.
Fernández Aceñero MJ, Hernández Gómez MJ, Blanco González J, Suárez Aliaga B
Minerva Urol Nefrol 1997 Sep;49(3):145-9. PMID: 9396222
Skeletal mastocytosis.
Andrew SM, Freemont AJ
J Clin Pathol 1993 Nov;46(11):1033-5. doi: 10.1136/jcp.46.11.1033. PMID: 8254091Free PMC Article

Clinical prediction guides

Pediatric and Infantile Fibroblastic/Myofibroblastic Tumors in the Molecular Era.
Davis JL, Rudzinski ER
Surg Pathol Clin 2020 Dec;13(4):739-762. doi: 10.1016/j.path.2020.08.009. PMID: 33183731
Epithelioid Fibrous Histiocytoma: A Concise Review.
Felty CC, Linos K
Am J Dermatopathol 2019 Dec;41(12):879-883. doi: 10.1097/DAD.0000000000001272. PMID: 30289773
Unplanned Resection of Sarcoma.
Tedesco NS, Henshaw RM
J Am Acad Orthop Surg 2016 Mar;24(3):150-9. doi: 10.5435/JAAOS-D-15-00074. PMID: 26761037
Sarcoma diagnosis in the age of molecular pathology.
Demicco EG
Adv Anat Pathol 2013 Jul;20(4):264-74. doi: 10.1097/PAP.0b013e31829c2c7b. PMID: 23752088
Diagnosis and management of lipomatous tumors.
Dalal KM, Antonescu CR, Singer S
J Surg Oncol 2008 Mar 15;97(4):298-313. doi: 10.1002/jso.20975. PMID: 18286473

Recent systematic reviews

Clinical features and therapeutic management of choroidal osteoma: A systematic review.
Zhang L, Ran QB, Lei CY, Zhang MX
Surv Ophthalmol 2023 Nov-Dec;68(6):1084-1092. Epub 2023 Jun 14 doi: 10.1016/j.survophthal.2023.06.002. PMID: 37321477
Management of phyllodes tumor: A systematic review and meta-analysis of real-world evidence.
Yu CY, Huang TW, Tam KW
Int J Surg 2022 Nov;107:106969. Epub 2022 Oct 31 doi: 10.1016/j.ijsu.2022.106969. PMID: 36328344
Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Malignant phyllodes tumor of the breast: a systematic review.
Lissidini G, Mulè A, Santoro A, Papa G, Nicosia L, Cassano E, Ashoor AA, Veronesi P, Pantanowitz L, Hornick JL, Rossi ED
Pathologica 2022 Apr;114(2):111-120. Epub 2022 Apr 13 doi: 10.32074/1591-951X-754. PMID: 35414723Free PMC Article
Paediatric mastocytosis: a systematic review of 1747 cases.
Méni C, Bruneau J, Georgin-Lavialle S, Le Saché de Peufeilhoux L, Damaj G, Hadj-Rabia S, Fraitag S, Dubreuil P, Hermine O, Bodemer C
Br J Dermatol 2015 Mar;172(3):642-51. Epub 2015 Feb 8 doi: 10.1111/bjd.13567. PMID: 25662299

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