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Increased corneal thickness

MedGen UID:
816781
•Concept ID:
C3810451
•
Finding
HPO: HP:0011487

Definition

A increased anteroposterior thickness of the cornea. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased corneal thickness

Conditions with this feature

Congenital hereditary endothelial dystrophy of cornea
MedGen UID:
387857
•Concept ID:
C1857569
•
Congenital Abnormality
Congenital hereditary endothelial dystrophy II (CHED II) is a rare subtype of posterior corneal dystrophy (see this term) characterized by a diffuse ground-glass appearance of the corneas and marked corneal thickening from birth with nystagmus, and blurred vision.
See: Condition Record
Congenital stromal corneal dystrophy
MedGen UID:
400601
•Concept ID:
C1864738
•
Disease or Syndrome
Congenital stromal corneal dystrophy is characterized by the presence of bilateral corneal opacities that can be seen at or shortly after birth. The surface of the cornea is normal or slightly irregular; small opacities are seen throughout the stroma of the entire cornea and give the cornea a cloudy appearance. Strabismus is common. Nystagmus is uncommon. Amblyopia can develop in children.
See: Condition Record
Congenital hereditary endothelial dystrophy of cornea
Congenital stromal corneal dystrophy

Professional guidelines

PubMed

Investigation of ocular events associated with taprenepag isopropyl, a topical EP2 agonist in development for treatment of glaucoma.
Yanochko GM, Affolter T, Eighmy JJ, Evans MG, Khoh-Reiter S, Lee D, Miller PE, Shiue MH, Trajkovic D, Jessen BA
J Ocul Pharmacol Ther 2014 Jun;30(5):429-39. Epub 2014 Apr 10 doi: 10.1089/jop.2013.0222. PMID: 24720348

Recent clinical studies

Etiology

Long-Term Real-World Outcomes of Corneal Changes in Proliferative Diabetic Retinopathy: Panretinal Photocoagulation vs. Intravitreal Conbercept.
Li Z, Zhou L, Huang C, Lu T, Liang J, Cong Q, Lan Y, Jin C
Photodiagnosis Photodyn Ther 2023 Dec;44:103765. Epub 2023 Aug 23 doi: 10.1016/j.pdpdt.2023.103765. PMID: 37625766
Corneal Parameters after Tube-Shunt Implantation through the Ciliary Sulcus.
Weiner AJ, Weiner Y, Weiner A
Ophthalmol Glaucoma 2021 Jan-Feb;4(1):32-41. Epub 2020 Jul 31 doi: 10.1016/j.ogla.2020.07.009. PMID: 32739403
Morning Myopic Shift and Glare in Advanced Fuchs Endothelial Corneal Dystrophy.
Loreck N, Adler W, Siebelmann S, Rokohl AC, Heindl LM, Cursiefen C, Bachmann BO, Matthaei M
Am J Ophthalmol 2020 May;213:69-75. Epub 2020 Jan 16 doi: 10.1016/j.ajo.2020.01.011. PMID: 31954712
Hypotony Keratopathy Following Trabeculectomy.
Camp AS, Weinreb RN
J Glaucoma 2020 Feb;29(2):77-80. doi: 10.1097/IJG.0000000000001425. PMID: 31876870
Advances in the management of congenital and infantile cataract.
Lloyd IC, Ashworth J, Biswas S, Abadi RV
Eye (Lond) 2007 Oct;21(10):1301-9. doi: 10.1038/sj.eye.6702845. PMID: 17914433

Diagnosis

Anterior chamber intraocular lens removal combined with triple DMEK: Quadruple DMEK for bullous keratopathy.
Mergen B, Berger T, Hamon L, Daas L, Seitz B
Eur J Ophthalmol 2024 May;34(3):NP13-NP17. Epub 2023 Nov 8 doi: 10.1177/11206721231213684. PMID: 37941333
Protective effect of Tisochrysis lutea on dry eye syndrome via NF-κB inhibition.
Hong SC, Yu HS, Kim JW, Lee EH, Pan CH, Hong KW, Kim JC
Sci Rep 2022 Nov 15;12(1):19576. doi: 10.1038/s41598-022-23545-7. PMID: 36380046Free PMC Article
Hypotony Keratopathy Following Trabeculectomy.
Camp AS, Weinreb RN
J Glaucoma 2020 Feb;29(2):77-80. doi: 10.1097/IJG.0000000000001425. PMID: 31876870
Increased corneal thickness in patients with ocular coloboma.
Tang J, Gokhale PA, Brooks SE, Blain D, Brooks BP
J AAPOS 2006 Apr;10(2):175-7. doi: 10.1016/j.jaapos.2005.12.003. PMID: 16678756
Ultrasonic characteristics of retinopathy of prematurity presenting with leukokoria.
Shapiro DR, Stone RD
Arch Ophthalmol 1985 Nov;103(11):1690-2. doi: 10.1001/archopht.1985.01050110084031. PMID: 3904685

Therapy

Long-Term Real-World Outcomes of Corneal Changes in Proliferative Diabetic Retinopathy: Panretinal Photocoagulation vs. Intravitreal Conbercept.
Li Z, Zhou L, Huang C, Lu T, Liang J, Cong Q, Lan Y, Jin C
Photodiagnosis Photodyn Ther 2023 Dec;44:103765. Epub 2023 Aug 23 doi: 10.1016/j.pdpdt.2023.103765. PMID: 37625766
Novel Proposed Algorithm in Congenital Hereditary Endothelial Dystrophy.
Mehta N, Ramappa M
Semin Ophthalmol 2023 Feb;38(2):108-115. Epub 2022 Jun 28 doi: 10.1080/08820538.2022.2094713. PMID: 35763407
Hypotony Keratopathy Following Trabeculectomy.
Camp AS, Weinreb RN
J Glaucoma 2020 Feb;29(2):77-80. doi: 10.1097/IJG.0000000000001425. PMID: 31876870
Advances in the management of congenital and infantile cataract.
Lloyd IC, Ashworth J, Biswas S, Abadi RV
Eye (Lond) 2007 Oct;21(10):1301-9. doi: 10.1038/sj.eye.6702845. PMID: 17914433
Transparency, swelling and scarring in the corneal stroma.
Meek KM, Leonard DW, Connon CJ, Dennis S, Khan S
Eye (Lond) 2003 Nov;17(8):927-36. doi: 10.1038/sj.eye.6700574. PMID: 14631399

Prognosis

Novel DCN Mutation in Armenian Family With Congenital Stromal Corneal Dystrophy.
Williams D, Chung DD, Hovakimyan A, Davtyan A, Glasgow BJ, Aldave AJ
Cornea 2023 Apr 1;42(4):464-469. Epub 2022 Dec 19 doi: 10.1097/ICO.0000000000003167. PMID: 36534610
Fresh Human Myopic Lenticule Intrastromal Implantation for Keratoconus Using SMILE Surgery in a Long-term Follow-up Study: Ultrastructural Analysis by Transmission Electron Microscopy.
Semiz F, Lokaj AS, Tanriverdi G, Caliskan G, Hima-Musa N, Semiz CE
J Refract Surg 2022 Aug;38(8):520-528. Epub 2022 Aug 1 doi: 10.3928/1081597X-20220713-02. PMID: 35947000
Corneal Parameters after Tube-Shunt Implantation through the Ciliary Sulcus.
Weiner AJ, Weiner Y, Weiner A
Ophthalmol Glaucoma 2021 Jan-Feb;4(1):32-41. Epub 2020 Jul 31 doi: 10.1016/j.ogla.2020.07.009. PMID: 32739403
Advances in the management of congenital and infantile cataract.
Lloyd IC, Ashworth J, Biswas S, Abadi RV
Eye (Lond) 2007 Oct;21(10):1301-9. doi: 10.1038/sj.eye.6702845. PMID: 17914433
Corneal endothelium five years after transplantation.
Bourne WM, Hodge DO, Nelson LR
Am J Ophthalmol 1994 Aug 15;118(2):185-96. doi: 10.1016/s0002-9394(14)72898-3. PMID: 8053464

Clinical prediction guides

Long-Term Real-World Outcomes of Corneal Changes in Proliferative Diabetic Retinopathy: Panretinal Photocoagulation vs. Intravitreal Conbercept.
Li Z, Zhou L, Huang C, Lu T, Liang J, Cong Q, Lan Y, Jin C
Photodiagnosis Photodyn Ther 2023 Dec;44:103765. Epub 2023 Aug 23 doi: 10.1016/j.pdpdt.2023.103765. PMID: 37625766
Novel DCN Mutation in Armenian Family With Congenital Stromal Corneal Dystrophy.
Williams D, Chung DD, Hovakimyan A, Davtyan A, Glasgow BJ, Aldave AJ
Cornea 2023 Apr 1;42(4):464-469. Epub 2022 Dec 19 doi: 10.1097/ICO.0000000000003167. PMID: 36534610
Fresh Human Myopic Lenticule Intrastromal Implantation for Keratoconus Using SMILE Surgery in a Long-term Follow-up Study: Ultrastructural Analysis by Transmission Electron Microscopy.
Semiz F, Lokaj AS, Tanriverdi G, Caliskan G, Hima-Musa N, Semiz CE
J Refract Surg 2022 Aug;38(8):520-528. Epub 2022 Aug 1 doi: 10.3928/1081597X-20220713-02. PMID: 35947000
Effect of glaucoma drainage implant surgery on corneal topography: a prospective study.
Koivusalo R, Välimäki J
Acta Ophthalmol 2020 May;98(3):305-309. Epub 2019 Sep 8 doi: 10.1111/aos.14247. PMID: 31495070
Mumps-induced corneal endotheliitis.
Singh K, Sodhi PK
Cornea 2004 May;23(4):400-2. doi: 10.1097/00003226-200405000-00017. PMID: 15097138

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