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Adult Acute Erythroid Leukemia

MedGen UID:
79015
•Concept ID:
C0279619
•
Neoplastic Process
Synonym: Adult Acute M6 Leukemia

Definition

An acute erythroid leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Erythroid Leukemia

Professional guidelines

PubMed

Pure (acute) erythroid leukemia: morphology, immunophenotype, cytogenetics, mutations, treatment details, and survival data among 41 Mayo Clinic cases.
Reichard KK, Tefferi A, Abdelmagid M, Orazi A, Alexandres C, Haack J, Greipp PT
Blood Cancer J 2022 Nov 2;12(11):147. doi: 10.1038/s41408-022-00746-x. PMID: 36323674Free PMC Article
The treatment of acute myeliod leukaemia.
Friend JH, Giles C, Richardson SG
J Clin Pathol 1974 Jan;27(1):53-4. doi: 10.1136/jcp.27.1.53. PMID: 4522738Free PMC Article
Adult acute leukaemia--a suitable case for treatment?
Hamblin TJ, Jones JV
Bristol Med Chir J 1973 Jan;88(325):11-5. PMID: 4520547Free PMC Article

Recent clinical studies

Etiology

Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy.
Yu K, Deuitch N, Merguerian M, Cunningham L, Davis J, Bresciani E, Diemer J, Andrews E, Young A, Donovan F, Sood R, Craft K, Chong S, Chandrasekharappa S, Mullikin J, Liu PP
Blood Adv 2024 Jan 23;8(2):497-511. doi: 10.1182/bloodadvances.2023011165. PMID: 38019014Free PMC Article
Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.
Platzbecker U, Della Porta MG, Santini V, Zeidan AM, Komrokji RS, Shortt J, Valcarcel D, Jonasova A, Dimicoli-Salazar S, Tiong IS, Lin CC, Li J, Zhang J, Giuseppi AC, Kreitz S, Pozharskaya V, Keeperman KL, Rose S, Shetty JK, Hayati S, Vodala S, Prebet T, Degulys A, Paolini S, Cluzeau T, Fenaux P, Garcia-Manero G
Lancet 2023 Jul 29;402(10399):373-385. Epub 2023 Jun 10 doi: 10.1016/S0140-6736(23)00874-7. PMID: 37311468
Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ, Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S, Shimamura A, Godley LA, Hahn CN, Churpek JE, Scott HS
Blood 2016 Feb 25;127(8):1017-23. Epub 2015 Dec 28 doi: 10.1182/blood-2015-10-676098. PMID: 26712909Free PMC Article
Is it justified to perform a bone marrow biopsy examination in sustained erythrocytosis?
Thiele J, Kvasnicka HM
Curr Hematol Malig Rep 2006 Jun;1(2):87-92. doi: 10.1007/s11899-006-0028-1. PMID: 20425337
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.
Platzbecker U, Della Porta MG, Santini V, Zeidan AM, Komrokji RS, Shortt J, Valcarcel D, Jonasova A, Dimicoli-Salazar S, Tiong IS, Lin CC, Li J, Zhang J, Giuseppi AC, Kreitz S, Pozharskaya V, Keeperman KL, Rose S, Shetty JK, Hayati S, Vodala S, Prebet T, Degulys A, Paolini S, Cluzeau T, Fenaux P, Garcia-Manero G
Lancet 2023 Jul 29;402(10399):373-385. Epub 2023 Jun 10 doi: 10.1016/S0140-6736(23)00874-7. PMID: 37311468
Is it justified to perform a bone marrow biopsy examination in sustained erythrocytosis?
Thiele J, Kvasnicka HM
Curr Hematol Malig Rep 2006 Jun;1(2):87-92. doi: 10.1007/s11899-006-0028-1. PMID: 20425337
Pure erythroid leukemia.
Huang Q
Arch Pathol Lab Med 2004 Feb;128(2):241-2. doi: 10.5858/2004-128-241-PEL. PMID: 14736271
Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group.
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440
The myeloproliferative disorders.
Gilbert HS, Dameshek W
Dis Mon 1970 Oct:1-52. doi: 10.1016/s0011-5029(70)80012-8. PMID: 4921953

Therapy

Genomic landscape of patients with germline RUNX1 variants and familial platelet disorder with myeloid malignancy.
Yu K, Deuitch N, Merguerian M, Cunningham L, Davis J, Bresciani E, Diemer J, Andrews E, Young A, Donovan F, Sood R, Craft K, Chong S, Chandrasekharappa S, Mullikin J, Liu PP
Blood Adv 2024 Jan 23;8(2):497-511. doi: 10.1182/bloodadvances.2023011165. PMID: 38019014Free PMC Article
Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.
Platzbecker U, Della Porta MG, Santini V, Zeidan AM, Komrokji RS, Shortt J, Valcarcel D, Jonasova A, Dimicoli-Salazar S, Tiong IS, Lin CC, Li J, Zhang J, Giuseppi AC, Kreitz S, Pozharskaya V, Keeperman KL, Rose S, Shetty JK, Hayati S, Vodala S, Prebet T, Degulys A, Paolini S, Cluzeau T, Fenaux P, Garcia-Manero G
Lancet 2023 Jul 29;402(10399):373-385. Epub 2023 Jun 10 doi: 10.1016/S0140-6736(23)00874-7. PMID: 37311468
Subacute anthracycline cardiotoxicity.
Hengel CL, Russell PA, Gould PA, Kaye DM
Heart Lung Circ 2006 Feb;15(1):59-61. Epub 2005 Nov 11 doi: 10.1016/j.hlc.2005.06.003. PMID: 16473794
Neutropenic enterocolitis in adults: case series and review of the literature.
Cunningham SC, Fakhry K, Bass BL, Napolitano LM
Dig Dis Sci 2005 Feb;50(2):215-20. doi: 10.1007/s10620-005-1585-1. PMID: 15745075
Giant mitochondria in erythroleukaemia.
Ghadially FN, Skinnider LF
J Pathol 1974 Nov;114(3):113-7. doi: 10.1002/path.1711140302. PMID: 4532688

Prognosis

Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.
Platzbecker U, Della Porta MG, Santini V, Zeidan AM, Komrokji RS, Shortt J, Valcarcel D, Jonasova A, Dimicoli-Salazar S, Tiong IS, Lin CC, Li J, Zhang J, Giuseppi AC, Kreitz S, Pozharskaya V, Keeperman KL, Rose S, Shetty JK, Hayati S, Vodala S, Prebet T, Degulys A, Paolini S, Cluzeau T, Fenaux P, Garcia-Manero G
Lancet 2023 Jul 29;402(10399):373-385. Epub 2023 Jun 10 doi: 10.1016/S0140-6736(23)00874-7. PMID: 37311468
JAK/MAP kinase pathway activation and TP53 mutations in acute leukemia with megakaryocytic and erythroid differentiation.
Xiao W, Rampal R, Zhang Y, Cimera R, Jungbluth AA, Arcila M, Roshal M, Park DC
Leukemia 2018 Aug;32(8):1842-1845. Epub 2018 Apr 24 doi: 10.1038/s41375-018-0145-6. PMID: 29743724Free PMC Article
Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ, Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S, Shimamura A, Godley LA, Hahn CN, Churpek JE, Scott HS
Blood 2016 Feb 25;127(8):1017-23. Epub 2015 Dec 28 doi: 10.1182/blood-2015-10-676098. PMID: 26712909Free PMC Article
Therapy-related pure erythroid leukemia with hepatic infiltration and hemophagocytic syndrome.
Funakoshi Y, Matsuoka H, Yamamoto K, Yakushijin K, Inui Y, Okamura A, Takeuchi M, Yokozaki H, Minami H
Intern Med 2011;50(24):3031-5. Epub 2011 Dec 15 doi: 10.2169/internalmedicine.50.6168. PMID: 22185999
Cytogenetic analysis in leukemia.
Meisner LF
CRC Crit Rev Clin Lab Sci 1975 Oct;6(3):157-200. doi: 10.3109/10408367509151570. PMID: 1104261

Clinical prediction guides

Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.
Platzbecker U, Della Porta MG, Santini V, Zeidan AM, Komrokji RS, Shortt J, Valcarcel D, Jonasova A, Dimicoli-Salazar S, Tiong IS, Lin CC, Li J, Zhang J, Giuseppi AC, Kreitz S, Pozharskaya V, Keeperman KL, Rose S, Shetty JK, Hayati S, Vodala S, Prebet T, Degulys A, Paolini S, Cluzeau T, Fenaux P, Garcia-Manero G
Lancet 2023 Jul 29;402(10399):373-385. Epub 2023 Jun 10 doi: 10.1016/S0140-6736(23)00874-7. PMID: 37311468
Myelodysplastic Syndromes: A New Decade.
Volpe VO, Garcia-Manero G, Komrokji RS
Clin Lymphoma Myeloma Leuk 2022 Jan;22(1):1-16. Epub 2021 Aug 2 doi: 10.1016/j.clml.2021.07.031. PMID: 34544674
Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Lewinsohn M, Brown AL, Weinel LM, Phung C, Rafidi G, Lee MK, Schreiber AW, Feng J, Babic M, Chong CE, Lee Y, Yong A, Suthers GK, Poplawski N, Altree M, Phillips K, Jaensch L, Fine M, D'Andrea RJ, Lewis ID, Medeiros BC, Pollyea DA, King MC, Walsh T, Keel S, Shimamura A, Godley LA, Hahn CN, Churpek JE, Scott HS
Blood 2016 Feb 25;127(8):1017-23. Epub 2015 Dec 28 doi: 10.1182/blood-2015-10-676098. PMID: 26712909Free PMC Article
Clinicopathologic features and outcome of acute erythroid leukemia based on 2008 revised World Health Organization classification.
Liu CJ, Hong YC, Yang CF, Liu SH, Gau JP, Liu JH, Hsiao LT, Liu CY, Yu YB, Tzeng CH
Leuk Lymphoma 2012 Feb;53(2):289-94. Epub 2011 Sep 23 doi: 10.3109/10428194.2011.607526. PMID: 21780998
Synthesis of adult-type hemoglobin in human erythremia cell line.
Kaku M, Yagawa K, Nakamura K, Okano H
Blood 1984 Jul;64(1):314-7. PMID: 6203576

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