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Adult Acute Monoblastic Leukemia

MedGen UID:
76004
Concept ID:
C0279629
Neoplastic Process
Synonyms: Adult Acute M5a Leukemia; M5a Adult Acute Leukemia; M5a Adult Acute Poorly Differentiated Monoblastic Leukemia

Definition

An acute monoblastic leukemia occurring in adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Acute Monoblastic Leukemia

Professional guidelines

PubMed

Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Uzuka Y
Nihon Ketsueki Gakkai Zasshi 1980 Dec;43(6):1057-66. PMID: 6949426
Gee TS, Yu KP, Clarkson BD
Cancer 1969 May;23(5):1019-32. doi: 10.1002/1097-0142(196905)23:5<1019::aid-cncr2820230506>3.0.co;2-n. PMID: 5252232

Recent clinical studies

Etiology

Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Favre R, Sebahoun G, Bagarry-Liégey D, Imbert C, Ciardelli P, Gastaut JA, Meyer G, Carcassonne Y
Recent Results Cancer Res 1982;80:56-63. doi: 10.1007/978-3-642-81685-7_9. PMID: 7036297
Infante PF, Rinsky RA, Wagoner JK, Young RJ
Lancet 1977 Jul 9;2(8028):76-8. doi: 10.1016/s0140-6736(77)90074-5. PMID: 69157
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Diagnosis

Rogers E, Cusnir M
N Engl J Med 2022 Jan 6;386(1):79. doi: 10.1056/NEJMicm2113297. PMID: 34986288
Beatty CJ, Ghareeb ER
N Engl J Med 2021 Aug 5;385(6):e19. doi: 10.1056/NEJMicm2101571. PMID: 34347955
Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT
Cancer Discov 2020 Apr;10(4):536-551. Epub 2020 Jan 23 doi: 10.1158/2159-8290.CD-19-0710. PMID: 31974170Free PMC Article
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, Sultan C
Br J Haematol 1976 Aug;33(4):451-8. doi: 10.1111/j.1365-2141.1976.tb03563.x. PMID: 188440

Therapy

Beatty CJ, Ghareeb ER
N Engl J Med 2021 Aug 5;385(6):e19. doi: 10.1056/NEJMicm2101571. PMID: 34347955
Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello JC, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D'Alessandro A, Gutman JA, Ramsey HE, Savona MR, Smith CA, Jordan CT
Cancer Discov 2020 Apr;10(4):536-551. Epub 2020 Jan 23 doi: 10.1158/2159-8290.CD-19-0710. PMID: 31974170Free PMC Article
Brierley CK, Eyre TA
Blood 2017 Jun 22;129(25):3396. doi: 10.1182/blood-2017-03-765776. PMID: 28642361
Ohno S, Yokoo T, Ohta M, Yamamoto M, Danno K, Hamato N, Tomii K, Ohno Y, Kobashi Y
J Am Acad Dermatol 1990 Feb;22(2 Pt 2):374-7. doi: 10.1016/0190-9622(90)70052-j. PMID: 2406302
Kyle RA, Pierre RV, Bayrd ED
N Engl J Med 1970 Nov 19;283(21):1121-5. doi: 10.1056/NEJM197011192832101. PMID: 5273282

Prognosis

Terao T, Matsue K
N Engl J Med 2021 Feb 18;384(7):650. doi: 10.1056/NEJMicm2026508. PMID: 33596359
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Valent P, Orazi A, Savona MR, Patnaik MM, Onida F, van de Loosdrecht AA, Haase D, Haferlach T, Elena C, Pleyer L, Kern W, Pemovska T, Vladimer GI, Schanz J, Keller A, Lübbert M, Lion T, Sotlar K, Reiter A, De Witte T, Pfeilstöcker M, Geissler K, Padron E, Deininger M, Orfao A, Horny HP, Greenberg PL, Arber DA, Malcovati L, Bennett JM
Haematologica 2019 Oct;104(10):1935-1949. Epub 2019 May 2 doi: 10.3324/haematol.2019.222059. PMID: 31048353Free PMC Article
Miyoshi I, Uemura Y, Sonobe H, Taguchi H
Intern Med 2007;46(1):65-6. Epub 2007 Jan 1 doi: 10.2169/internalmedicine.46.6232. PMID: 17202740
Infante PF, Rinsky RA, Wagoner JK, Young RJ
Lancet 1977 Jul 9;2(8028):76-8. doi: 10.1016/s0140-6736(77)90074-5. PMID: 69157

Clinical prediction guides

Peterlin P, Debord C, Eveillard M, Garnier A, Le Bourgeois A, Guillaume T, Jullien M, Béné MC, Chevallier P
J Cell Mol Med 2022 Nov;26(21):5486-5492. Epub 2022 Oct 13 doi: 10.1111/jcmm.17576. PMID: 36226545Free PMC Article
Shallis RM, Siddon AJ, Zeidan AM
Curr Hematol Malig Rep 2021 Jun;16(3):276-285. Epub 2021 Apr 22 doi: 10.1007/s11899-021-00632-6. PMID: 33890194
Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL, Aifantis I
Cancer Cell 2020 Jun 8;37(6):867-882.e12. Epub 2020 May 28 doi: 10.1016/j.ccell.2020.04.015. PMID: 32470390Free PMC Article
Hahn A, Giri S, Yaghmour G, Martin MG
Leuk Res 2015 May;39(5):505-9. Epub 2015 Feb 9 doi: 10.1016/j.leukres.2015.02.003. PMID: 25726083
Infante PF, Rinsky RA, Wagoner JK, Young RJ
Lancet 1977 Jul 9;2(8028):76-8. doi: 10.1016/s0140-6736(77)90074-5. PMID: 69157

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