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Breast Columnar Cell Lesion

MedGen UID:: 317529
•Concept ID:: C1707448
•: Neoplastic Process

Synonyms:

Columnar Cell Lesion of Breast; Columnar Cell Lesion of the Breast

Definition

A morphologic spectrum of lesions that arise in the terminal ductal lobular units of the breast parenchyma. These lesions are characterized by the presence of columnar epithelial cells that line dilated terminal ductal lobular units. Cytological and architectural atypia may be absent or minimal, or significant enough to raise the possibility of atypical ductal hyperplasia or ductal carcinoma in situ. Columnar cell lesions are frequently found in breast biopsies but their biologic significance is not known. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBreast Columnar Cell Lesion

Phenotypic abnormality
- Abnormality of the breast
  - Abnormal breast morphology
    - Breast neoplasm
      - Breast Columnar Cell Lesion
        Columnar Cell Change of the Breast
        Columnar Cell Change of the Breast with Atypia
        Columnar cell hyperplasia of the breast
        Breast Columnar Cell Hyperplasia with Atypia

Professional guidelines

PubMed

Pitfalls and controversies in pathology impacting breast cancer management.

Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198

Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.

Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.

Schnitt SJ
Breast Cancer Res 2003;5(5):263-8. Epub 2003 Jul 29 doi: 10.1186/bcr625. PMID: 12927037 Free PMC Article

See all (12)

Recent clinical studies

Etiology

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?

Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185 Free PMC Article

Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.

Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

Columnar cell lesions of the breast: an update and significance on core biopsy.

Jara-Lazaro AR, Tse GM, Tan PH
Pathology 2009 Jan;41(1):18-27. doi: 10.1080/00313020802563486. PMID: 19089736

Pathology of high-risk breast lesions and ductal carcinoma in situ.

Sewell CW
Radiol Clin North Am 2004 Sep;42(5):821-30, v. doi: 10.1016/j.rcl.2004.03.013. PMID: 15337418

The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.

Schnitt SJ
Breast Cancer Res 2003;5(5):263-8. Epub 2003 Jul 29 doi: 10.1186/bcr625. PMID: 12927037 Free PMC Article

See all (90)

Diagnosis

Papillomatous breast lesions with atypical columnar cell features.

de Boer M, Verschuur-Maes AHJ, Moelans C, van Diest PJ
J Clin Pathol 2023 Apr;76(4):228-233. Epub 2023 Jan 24 doi: 10.1136/jcp-2022-208389. PMID: 36693714

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?

Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185 Free PMC Article

Pitfalls and controversies in pathology impacting breast cancer management.

Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198

Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.

Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875

The diagnosis and management of pre-invasive breast disease: flat epithelial atypia--classification, pathologic features and clinical significance.

Schnitt SJ
Breast Cancer Res 2003;5(5):263-8. Epub 2003 Jul 29 doi: 10.1186/bcr625. PMID: 12927037 Free PMC Article

See all (117)

Therapy

Testosterone therapy and breast histopathological features in transgender individuals.

Baker GM, Guzman-Arocho YD, Bret-Mounet VC, Torous VF, Schnitt SJ, Tobias AM, Bartlett RA, Fein-Zachary VJ, Collins LC, Wulf GM, Heng YJ
Mod Pathol 2021 Jan;34(1):85-94. Epub 2020 Sep 16 doi: 10.1038/s41379-020-00675-9. PMID: 32939016 Free PMC Article

Columnar Cell Lesion and Apocrine Hyperplasia of the Breast: Is There a Common Origin? The Role of Prolactin-induced Protein.

Sciarra A, Lopez G, Corti C, Runza L, Ercoli G, Bonometti A, Despini L, Blundo C, Gambini D, Fusco N
Appl Immunohistochem Mol Morphol 2019 Aug;27(7):508-514. doi: 10.1097/PAI.0000000000000604. PMID: 29084054

HPV and cervical cancer.

Petry KU
Scand J Clin Lab Invest Suppl 2014;244:59-62; discussion 62. doi: 10.3109/00365513.2014.936683. PMID: 25083895

A multi-center prospective cohort study of benign breast disease and risk of subsequent breast cancer.

Kabat GC, Jones JG, Olson N, Negassa A, Duggan C, Ginsberg M, Kandel RA, Glass AG, Rohan TE
Cancer Causes Control 2010 Jun;21(6):821-8. Epub 2010 Jan 19 doi: 10.1007/s10552-010-9508-7. PMID: 20084540 Free PMC Article

Columnar cell lesions, mammographic density and breast cancer risk.

Turashvili G, McKinney S, Martin L, Gelmon KA, Watson P, Boyd N, Aparicio S
Breast Cancer Res Treat 2009 Jun;115(3):561-71. Epub 2008 Jun 28 doi: 10.1007/s10549-008-0099-x. PMID: 18587641

See all (7)

Prognosis

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?

Strickland S, Turashvili G
Curr Oncol 2022 Aug 11;29(8):5664-5681. doi: 10.3390/curroncol29080447. PMID: 36005185 Free PMC Article

Pitfalls and controversies in pathology impacting breast cancer management.

Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198

Positive predictive value for malignancy of pure flat epithelial atypia diagnosis by percutaneous needle biopsy of the breast: management of FEA in ultrasonography.

Maeda I, Kanemaki Y, Tozaki M, Koizumi H, Oana Y, Okanami Y, Tsuchiya K, Shimo A, Kojima Y, Hayami R, Nishikawa T, Kawamoto H, Yabuki Y, Tsugawa K, Takagi M
Breast Cancer 2015 Nov;22(6):634-40. Epub 2014 Apr 24 doi: 10.1007/s12282-014-0530-6. PMID: 24760612

Columnar cell-like changes in the male breast.

Ni YB, Mujtaba S, Shao MM, Lacambra M, Tsang JY, Chan SK, Tse GM
J Clin Pathol 2014 Jan;67(1):45-8. Epub 2013 Aug 6 doi: 10.1136/jclinpath-2013-201631. PMID: 23922357

Morphological observations regarding the origins of atypical cystic lobules (low-grade clinging carcinoma of flat type).

Koerner FC, Oyama T, Maluf H
Virchows Arch 2001 Oct;439(4):523-30. doi: 10.1007/s004280100426. PMID: 11710639

See all (43)

Clinical prediction guides

Pitfalls and controversies in pathology impacting breast cancer management.

Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198

Positive predictive value for malignancy of pure flat epithelial atypia diagnosis by percutaneous needle biopsy of the breast: management of FEA in ultrasonography.

Current issues in diagnostic breast pathology.

Walker RA, Hanby A, Pinder SE, Thomas J, Ellis IO; National Coordinating Committee for Breast Pathology Research Subgroup
J Clin Pathol 2012 Sep;65(9):771-85. Epub 2012 Jul 19 doi: 10.1136/jclinpath-2012-200733. PMID: 22813732

Borderline breast lesions: diagnostic challenges and clinical implications.

Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436

Non-operative breast pathology: columnar cell lesions.

Pinder SE, Reis-Filho JS
J Clin Pathol 2007 Dec;60(12):1307-12. Epub 2006 Dec 20 doi: 10.1136/jcp.2006.040634. PMID: 17182657 Free PMC Article

See all (58)