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Breast Papillary Ductal Hyperplasia

MedGen UID:
277494
•Concept ID:
C1335323
•
Neoplastic Process
Synonyms: Papillary Breast Hyperplasia; Papillary Duct Hyperplasia of Breast; Papillary Duct Hyperplasia of the Breast; Papillary Ductal Breast Hyperplasia; Papillary Hyperplasia of Breast; Papillary Hyperplasia of the Breast

Definition

Benign papillary proliferation within the ductal system of the breast parenchyma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Papillary Ductal Hyperplasia

Professional guidelines

PubMed

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198

Recent clinical studies

Etiology

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast - review and practical issues.
Ni Y, Tse GM
Semin Diagn Pathol 2022 Sep;39(5):344-354. Epub 2022 Jun 11 doi: 10.1053/j.semdp.2022.06.001. PMID: 35718581
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592

Diagnosis

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Apocrine lesions of the breast.
Quinn CM, D'Arcy C, Wells C
Virchows Arch 2022 Jan;480(1):177-189. Epub 2021 Sep 18 doi: 10.1007/s00428-021-03185-4. PMID: 34537861Free PMC Article
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889

Therapy

Development, validation, and comparison of a nomogram based on radiologic findings for predicting malignancy in intraductal papillary mucinous neoplasms of the pancreas: An international multicenter study.
Kim HS, Song W, Choo W, Lee S, Han Y, Bassi C, Salvia R, Marchegiani G, Wolfgang CL, He J, Blair AB, Kluger MD, Su GH, Kim SC, Song KB, Yamamoto M, Hatori T, Yang CY, Yamaue H, Hirono S, Satoi S, Fujii T, Hirano S, Lou W, Hashimoto Y, Shimizu Y, Del Chiaro M, Valente R, Lohr M, Choi DW, Choi SH, Heo JS, Motoi F, Matsumoto I, Lee WJ, Kang CM, Shyr YM, Wang SE, Han HS, Yoon YS, Besselink MG, van Huijgevoort NCM, Sho M, Nagano H, Kim SG, Honda G, Yang Y, Yu HC, Yang JD, Chung JC, Nagakawa Y, Seo HI, Lee S, Kim H, Kwon W, Park T, Jang JY
J Hepatobiliary Pancreat Sci 2023 Jan;30(1):133-143. Epub 2021 Apr 20 doi: 10.1002/jhbp.962. PMID: 33811460
B3 lesion upgrade rates in a tertiary Australian breast centre: a 8-year experience (2012-2019).
Huang YY, Park H, McLaren S, Thirunavukkarasu P, Lin JTW, Rajakaruna R, Dhillon R, Ponniah AK
ANZ J Surg 2020 Dec;90(12):2521-2526. Epub 2020 Sep 23 doi: 10.1111/ans.16315. PMID: 32969161
Risk of malignancy in papillary neoplasms of the breast.
Liu C, Sidhu R, Ostry A, Warburton R, Pao JS, Dingee C, Kuusk U, McKevitt E
Breast Cancer Res Treat 2019 Nov;178(1):87-94. Epub 2019 Jul 22 doi: 10.1007/s10549-019-05367-w. PMID: 31332665
Comparison of immunohistochemical staining in breast papillary neoplasms of cytokeratin 5/6 and p63 in core needle biopsies and surgical excisions.
Koo JS, Kim MJ, Kim EK, Park BW
Appl Immunohistochem Mol Morphol 2012 Mar;20(2):108-15. doi: 10.1097/pai.0b013e318235a917. PMID: 22553810
Epstein-Barr virus and breast cancer: lack of evidence for an association in Iranian women.
Kadivar M, Monabati A, Joulaee A, Hosseini N
Pathol Oncol Res 2011 Sep;17(3):489-92. Epub 2011 Jan 6 doi: 10.1007/s12253-010-9325-z. PMID: 21207256

Prognosis

European guidelines for the diagnosis, treatment and follow-up of breast lesions with uncertain malignant potential (B3 lesions) developed jointly by EUSOMA, EUSOBI, ESP (BWG) and ESSO.
Rubio IT, Wyld L, Marotti L, Athanasiou A, Regitnig P, Catanuto G, Schoones JW, Zambon M, Camps J, Santini D, Dietz J, Sardanelli F, Varga Z, Smidt M, Sharma N, Shaaban AM, Gilbert F
Eur J Surg Oncol 2024 Jan;50(1):107292. Epub 2023 Nov 27 doi: 10.1016/j.ejso.2023.107292. PMID: 38061151
Pitfalls and controversies in pathology impacting breast cancer management.
Kim WG, Cummings MC, Lakhani SR
Expert Rev Anticancer Ther 2020 Mar;20(3):205-219. Epub 2020 Mar 14 doi: 10.1080/14737140.2020.1738222. PMID: 32174198
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Papillary Lesions of the Male Breast: A Study of 117 Cases and Brief Review of the Literature Demonstrate a Broad Clinicopathologic Spectrum.
Zhong E, Cheng E, Goldfischer M, Hoda SA
Am J Surg Pathol 2020 Jan;44(1):68-76. doi: 10.1097/PAS.0000000000001340. PMID: 31403965
Risk of malignancy in papillary neoplasms of the breast.
Liu C, Sidhu R, Ostry A, Warburton R, Pao JS, Dingee C, Kuusk U, McKevitt E
Breast Cancer Res Treat 2019 Nov;178(1):87-94. Epub 2019 Jul 22 doi: 10.1007/s10549-019-05367-w. PMID: 31332665

Clinical prediction guides

Third International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions).
Elfgen C, Leo C, Kubik-Huch RA, Muenst S, Schmidt N, Quinn C, McNally S, van Diest PJ, Mann RM, Bago-Horvath Z, Bernathova M, Regitnig P, Fuchsjäger M, Schwegler-Guggemos D, Maranta M, Zehbe S, Tausch C, Güth U, Fallenberg EM, Schrading S, Kothari A, Sonnenschein M, Kampmann G, Kulka J, Tille JC, Körner M, Decker T, Lax SF, Daniaux M, Bjelic-Radisic V, Kacerovsky-Strobl S, Condorelli R, Gnant M, Varga Z
Virchows Arch 2023 Jul;483(1):5-20. Epub 2023 Jun 17 doi: 10.1007/s00428-023-03566-x. PMID: 37330436Free PMC Article
Papillary lesions of the breast.
Kulka J, Madaras L, Floris G, Lax SF
Virchows Arch 2022 Jan;480(1):65-84. Epub 2021 Nov 3 doi: 10.1007/s00428-021-03182-7. PMID: 34734332Free PMC Article
Immunohistochemistry for diagnosis and prognosis of breast cancer: a review.
Bonacho T, Rodrigues F, Liberal J
Biotech Histochem 2020 Feb;95(2):71-91. Epub 2019 Sep 10 doi: 10.1080/10520295.2019.1651901. PMID: 31502889
Borderline breast lesions: diagnostic challenges and clinical implications.
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436
Noninvasive papillary proliferations.
Oyama T, Koerner FC
Semin Diagn Pathol 2004 Feb;21(1):32-41. doi: 10.1053/j.semdp.2003.10.011. PMID: 15074557

Recent systematic reviews

The positive predictive value of vacuum assisted biopsy (VAB) in predicting final histological diagnosis for breast lesions of uncertain malignancy (B3 lesions): A systematic review & meta-analysis.
Cullinane C, Byrne J, Kelly L, O Sullivan M, Antony Corrigan M, Paul Redmond H
Eur J Surg Oncol 2022 Jul;48(7):1464-1474. Epub 2022 Apr 15 doi: 10.1016/j.ejso.2022.04.005. PMID: 35491362

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