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Poorly Differentiated Neuroblastoma

MedGen UID:
271330
•Concept ID:
C1514225
•
Neoplastic Process

Definition

A neuroblastoma in which the differentiating neuroblasts constitute less than five-percent of the tumor cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPoorly Differentiated Neuroblastoma

Professional guidelines

PubMed

Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee.
Suganuma R, Wang LL, Sano H, Naranjo A, London WB, Seeger RC, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Amann G, Beiske K, Cullinane CJ, d'Amore ES, Gambini C, Jarzembowski JA, Joshi VV, Navarro S, Peuchmaur M, Shimada H
Pediatr Blood Cancer 2013 Mar;60(3):363-70. Epub 2012 Jun 28 doi: 10.1002/pbc.24238. PMID: 22744966Free PMC Article

Recent clinical studies

Etiology

ALK Gene Mutation and ALK Protein Expression in Advanced Neuroblastoma and the Potential Value in Risk Stratification in Fine-Needle Aspiration Biopsy Samples.
Bhardwaj N, Rohilla M, Gautam U, Trehan A, Bansal D, Kakkar N, Srinivasan R
Am J Clin Pathol 2023 Apr 4;159(4):407-415. doi: 10.1093/ajcp/aqac172. PMID: 36812383
Demystifying neuroblastoma malignancy through fractal dimension, entropy, and lacunarity.
Donato I, Velpula KK, Tsung AJ, Tuszynski JA, Sergi CM
Tumori 2023 Aug;109(4):370-378. Epub 2023 Jan 16 doi: 10.1177/03008916221146208. PMID: 36645143
Anti-GRP-R monoclonal antibody antitumor therapy against neuroblastoma.
Qiao J, Liu J, Jacobson JC, Clark RA, Lee S, Liu L, An Z, Zhang N, Chung DH
PLoS One 2022;17(12):e0277956. Epub 2022 Dec 16 doi: 10.1371/journal.pone.0277956. PMID: 36525420Free PMC Article
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy.
Schulte JH, Lim S, Schramm A, Friedrichs N, Koster J, Versteeg R, Ora I, Pajtler K, Klein-Hitpass L, Kuhfittig-Kulle S, Metzger E, Schüle R, Eggert A, Buettner R, Kirfel J
Cancer Res 2009 Mar 1;69(5):2065-71. Epub 2009 Feb 17 doi: 10.1158/0008-5472.CAN-08-1735. PMID: 19223552
Pathology of peripheral neuroblastic tumors: significance of prominent nucleoli in undifferentiated/poorly differentiated neuroblastoma.
Tornóczky T, Semjén D, Shimada H, Ambros IM
Pathol Oncol Res 2007;13(4):269-75. Epub 2007 Dec 25 doi: 10.1007/BF02940304. PMID: 18158560

Diagnosis

Jaundice as a Rare Presentation of Neuroblastoma in a Pediatric Patient.
Xie P, Yang L, Wei L, Ma H, Yang J
Clin Nucl Med 2024 Nov 1;49(11):1033-1035. Epub 2024 Sep 25 doi: 10.1097/RLU.0000000000005432. PMID: 39325504
CD99 and NKX2.2 positive neuroblastoma diagnosed on cytology: A potential diagnostic pitfall and necessity of pathological evaluation of the primary site.
Aparna Devi C, Alashetty S, Champaka G, Dharmalingam P, Kapali A, Kumar N
Diagn Cytopathol 2023 Jun;51(6):E189-E194. Epub 2023 Mar 31 doi: 10.1002/dc.25124. PMID: 36999306
ALK Gene Mutation and ALK Protein Expression in Advanced Neuroblastoma and the Potential Value in Risk Stratification in Fine-Needle Aspiration Biopsy Samples.
Bhardwaj N, Rohilla M, Gautam U, Trehan A, Bansal D, Kakkar N, Srinivasan R
Am J Clin Pathol 2023 Apr 4;159(4):407-415. doi: 10.1093/ajcp/aqac172. PMID: 36812383
Demystifying neuroblastoma malignancy through fractal dimension, entropy, and lacunarity.
Donato I, Velpula KK, Tsung AJ, Tuszynski JA, Sergi CM
Tumori 2023 Aug;109(4):370-378. Epub 2023 Jan 16 doi: 10.1177/03008916221146208. PMID: 36645143
Adult neuroblastoma: a rare diagnosis of an adrenal mass.
Ramsingh J, Casey H, Watson C
BMJ Case Rep 2019 Apr 11;12(4) doi: 10.1136/bcr-2018-228730. PMID: 30975781Free PMC Article

Therapy

Metachronous Bilateral Adrenal Neuroblastoma: A Case Report and Literature Review.
Tropia S, Guarina A, Restivo GA, Di Francesco F, Trizzino A, D'Angelo P
J Pediatr Hematol Oncol 2024 Nov 1;46(8):429-432. Epub 2024 Sep 30 doi: 10.1097/MPH.0000000000002954. PMID: 39348319
Anti-GRP-R monoclonal antibody antitumor therapy against neuroblastoma.
Qiao J, Liu J, Jacobson JC, Clark RA, Lee S, Liu L, An Z, Zhang N, Chung DH
PLoS One 2022;17(12):e0277956. Epub 2022 Dec 16 doi: 10.1371/journal.pone.0277956. PMID: 36525420Free PMC Article
Dinutuximab in adult-onset chemotherapy refractory high-risk neuroblastoma.
Garrovillo K, Garrett J, Bollin K, Nasraty F, Sikand H
J Oncol Pharm Pract 2020 Dec;26(8):2058-2065. Epub 2020 May 1 doi: 10.1177/1078155220918920. PMID: 32356686
Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy.
Schulte JH, Lim S, Schramm A, Friedrichs N, Koster J, Versteeg R, Ora I, Pajtler K, Klein-Hitpass L, Kuhfittig-Kulle S, Metzger E, Schüle R, Eggert A, Buettner R, Kirfel J
Cancer Res 2009 Mar 1;69(5):2065-71. Epub 2009 Feb 17 doi: 10.1158/0008-5472.CAN-08-1735. PMID: 19223552
Management of chemotherapy in a pregnancy complicated by a large neuroblastoma.
Arango HA, Kalter CS, Decesare SL, Fiorica JV, Lyman GH, Spellacy WN
Obstet Gynecol 1994 Oct;84(4 Pt 2):665-8. PMID: 9205441

Prognosis

ALK Gene Mutation and ALK Protein Expression in Advanced Neuroblastoma and the Potential Value in Risk Stratification in Fine-Needle Aspiration Biopsy Samples.
Bhardwaj N, Rohilla M, Gautam U, Trehan A, Bansal D, Kakkar N, Srinivasan R
Am J Clin Pathol 2023 Apr 4;159(4):407-415. doi: 10.1093/ajcp/aqac172. PMID: 36812383
Demystifying neuroblastoma malignancy through fractal dimension, entropy, and lacunarity.
Donato I, Velpula KK, Tsung AJ, Tuszynski JA, Sergi CM
Tumori 2023 Aug;109(4):370-378. Epub 2023 Jan 16 doi: 10.1177/03008916221146208. PMID: 36645143
Composite Neuroblastoma Metastatic to a Lymph Node: The Novel Histopathologic Diagnosis of a Unique Multiclonal Neoplasm.
Kurtz JL, Shimada H, Hazard FK
Ann Clin Lab Sci 2021 Jul;51(4):573-579. PMID: 34452899
Pathology of peripheral neuroblastic tumors: significance of prominent nucleoli in undifferentiated/poorly differentiated neuroblastoma.
Tornóczky T, Semjén D, Shimada H, Ambros IM
Pathol Oncol Res 2007;13(4):269-75. Epub 2007 Dec 25 doi: 10.1007/BF02940304. PMID: 18158560
Management of chemotherapy in a pregnancy complicated by a large neuroblastoma.
Arango HA, Kalter CS, Decesare SL, Fiorica JV, Lyman GH, Spellacy WN
Obstet Gynecol 1994 Oct;84(4 Pt 2):665-8. PMID: 9205441

Clinical prediction guides

ALK Gene Mutation and ALK Protein Expression in Advanced Neuroblastoma and the Potential Value in Risk Stratification in Fine-Needle Aspiration Biopsy Samples.
Bhardwaj N, Rohilla M, Gautam U, Trehan A, Bansal D, Kakkar N, Srinivasan R
Am J Clin Pathol 2023 Apr 4;159(4):407-415. doi: 10.1093/ajcp/aqac172. PMID: 36812383
Demystifying neuroblastoma malignancy through fractal dimension, entropy, and lacunarity.
Donato I, Velpula KK, Tsung AJ, Tuszynski JA, Sergi CM
Tumori 2023 Aug;109(4):370-378. Epub 2023 Jan 16 doi: 10.1177/03008916221146208. PMID: 36645143
Pediatric neuroblastic tumors: A critical evaluation of cytomorphological features for risk stratification on aspiration cytology.
Behera G, Chhabra G, Mishra P, Sable M
Diagn Cytopathol 2020 May;48(5):464-474. Epub 2020 Feb 11 doi: 10.1002/dc.24389. PMID: 32043835
The Ewing family of tumors--a subgroup of small-round-cell tumors defined by specific chimeric transcripts.
Delattre O, Zucman J, Melot T, Garau XS, Zucker JM, Lenoir GM, Ambros PF, Sheer D, Turc-Carel C, Triche TJ
N Engl J Med 1994 Aug 4;331(5):294-9. doi: 10.1056/NEJM199408043310503. PMID: 8022439

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