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Benign vascular tumor

MedGen UID:
235124
•Concept ID:
C1377916
•
Neoplastic Process
Synonyms: Benign Vascular Neoplasm; Benign Vascular Tumor; benign vascular tumor; Vascular Neoplasms, Benign
 
Monarch Initiative: MONDO:0971115

Definition

A mesenchymal neoplasm that arises from vascular tissue usually of the skin. It is characterized by the presence of vascular channel formation and endothelial cells. There is no evidence of atypical or malignant cytological and architectural features, invasive features, or metastases. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign vascular tumor

Professional guidelines

PubMed

Update on the diagnosis and treatment of choroidal hemangioma.
García Caride S, Fernández-Vigo JI, Valverde-Megías A
Arch Soc Esp Oftalmol (Engl Ed) 2023 May;98(5):281-291. Epub 2023 Apr 14 doi: 10.1016/j.oftale.2023.04.006. PMID: 37062411
Circumscribed choroidal hemangioma: An overview of clinical manifestation, diagnosis and management.
Sen M, Honavar SG
Indian J Ophthalmol 2019 Dec;67(12):1965-1973. doi: 10.4103/ijo.IJO_2036_19. PMID: 31755430Free PMC Article
Kaposiform hemangioendothelioma in children: a benign vascular tumor with multiple treatment options.
Schmid I, Klenk AK, Sparber-Sauer M, Koscielniak E, Maxwell R, Häberle B
World J Pediatr 2018 Aug;14(4):322-329. Epub 2018 Jul 27 doi: 10.1007/s12519-018-0171-5. PMID: 30054848

Recent clinical studies

Etiology

Female Urethral Cavernous Hemangioma: Introducing Treatment and Follow-Up Course of Three Cases.
Mahmoudnejad N, Mohammadi Torbati P, Saberi N, Sodeifian F
Urol Int 2024;108(2):159-162. Epub 2023 Dec 29 doi: 10.1159/000535464. PMID: 38160670Free PMC Article
Oral atenolol compared to oral propranolol for infantile hemangioma.
Meza Viteri V, Aranibar L
Medwave 2023 Dec 7;23(11):e2753. doi: 10.5867/medwave.2023.11.2753. PMID: 38061014
Successful Medical Management of Life-threatening Hepatic Hemangioma in Neonates.
Lekwuttikarn R, Josephs S, Teng JM
Pediatrics 2019 Oct;144(4) Epub 2019 Sep 11 doi: 10.1542/peds.2019-1339. PMID: 31511312
Kaposiform hemangioendothelioma in children: a benign vascular tumor with multiple treatment options.
Schmid I, Klenk AK, Sparber-Sauer M, Koscielniak E, Maxwell R, Häberle B
World J Pediatr 2018 Aug;14(4):322-329. Epub 2018 Jul 27 doi: 10.1007/s12519-018-0171-5. PMID: 30054848
Intravascular Papillary Endothelial Hyperplasia at Foot Level: A Case Report and Literature Review.
Espinosa A, González J, García-Navas F
J Foot Ankle Surg 2017 Jan-Feb;56(1):72-74. doi: 10.1053/j.jfas.2016.09.016. PMID: 27989349

Diagnosis

Nasal Septal Angiofibroma.
Thobejane O, Maharaj S
Ear Nose Throat J 2023 Oct;102(10):NP483-NP484. Epub 2021 Jun 16 doi: 10.1177/01455613211026517. PMID: 34134540
A mobile hemangioblastoma of the cauda equina: Case report and review of the literature.
Luo H, Xiao J, Lv S, Zhu X, Cheng Z
J Spinal Cord Med 2020 Sep;43(5):719-722. Epub 2018 Nov 26 doi: 10.1080/10790268.2018.1547855. PMID: 30475166Free PMC Article
Choroidal hemangioma.
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200
Circumscribed choroidal hemangioma.
Mashayekhi A, Shields CL
Curr Opin Ophthalmol 2003 Jun;14(3):142-9. doi: 10.1097/00055735-200306000-00006. PMID: 12777933
Renal hemangioma.
Takeuchi T, Kuriyama M, Shinoda I, Nishiura T, Tei K, Matsushita I, Yamaha M, Isogai K
Hinyokika Kiyo 1984 Jun;30(6):767-74. PMID: 6485968

Therapy

Infantile hemangioma: the common and enigmatic vascular tumor.
Holm A, Mulliken JB, Bischoff J
J Clin Invest 2024 Apr 15;134(8) doi: 10.1172/JCI172836. PMID: 38618963Free PMC Article
Rare airway tumor in a previously healthy adolescent successfully treated with endoscopic resection and oral propranolol.
Gipsman AI, Treat JR, Piccione J
Pediatr Pulmonol 2023 Jul;58(7):2142-2144. Epub 2023 Apr 19 doi: 10.1002/ppul.26421. PMID: 37074104Free PMC Article
Medical Management of Infantile Hemangiomas: An Update.
Colmant C, Powell J
Paediatr Drugs 2022 Jan;24(1):29-43. Epub 2021 Oct 22 doi: 10.1007/s40272-021-00477-9. PMID: 34677814
Proanthocyanidins as a Potential Novel Way for the Treatment of Hemangioma.
Tang R, Xian D, Xu J, Peng H, Pan S, Zhong J
Biomed Res Int 2021;2021:5695378. Epub 2021 Jan 2 doi: 10.1155/2021/5695378. PMID: 33490272Free PMC Article
Kaposiform hemangioendothelioma in children: a benign vascular tumor with multiple treatment options.
Schmid I, Klenk AK, Sparber-Sauer M, Koscielniak E, Maxwell R, Häberle B
World J Pediatr 2018 Aug;14(4):322-329. Epub 2018 Jul 27 doi: 10.1007/s12519-018-0171-5. PMID: 30054848

Prognosis

Update on the diagnosis and treatment of choroidal hemangioma.
García Caride S, Fernández-Vigo JI, Valverde-Megías A
Arch Soc Esp Oftalmol (Engl Ed) 2023 May;98(5):281-291. Epub 2023 Apr 14 doi: 10.1016/j.oftale.2023.04.006. PMID: 37062411
Medical Management of Infantile Hemangiomas: An Update.
Colmant C, Powell J
Paediatr Drugs 2022 Jan;24(1):29-43. Epub 2021 Oct 22 doi: 10.1007/s40272-021-00477-9. PMID: 34677814
Kaposiform hemangioendothelioma in children: a benign vascular tumor with multiple treatment options.
Schmid I, Klenk AK, Sparber-Sauer M, Koscielniak E, Maxwell R, Häberle B
World J Pediatr 2018 Aug;14(4):322-329. Epub 2018 Jul 27 doi: 10.1007/s12519-018-0171-5. PMID: 30054848
Evolution of hemangioma endothelium.
Kleiman A, Keats EC, Chan NG, Khan ZA
Exp Mol Pathol 2012 Oct;93(2):264-72. Epub 2012 May 4 doi: 10.1016/j.yexmp.2012.04.020. PMID: 22565125
Choroidal hemangioma.
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200

Clinical prediction guides

Identification of Potential Therapeutics for Infantile Hemangioma via in silico Investigation and in vitro Validation.
Lu W, Yang Z, Wang M, Zhang Y, Qi Z, Yang X
Drug Des Devel Ther 2024;18:4065-4088. Epub 2024 Sep 12 doi: 10.2147/DDDT.S460575. PMID: 39286286Free PMC Article
Oral atenolol compared to oral propranolol for infantile hemangioma.
Meza Viteri V, Aranibar L
Medwave 2023 Dec 7;23(11):e2753. doi: 10.5867/medwave.2023.11.2753. PMID: 38061014
Medical Management of Infantile Hemangiomas: An Update.
Colmant C, Powell J
Paediatr Drugs 2022 Jan;24(1):29-43. Epub 2021 Oct 22 doi: 10.1007/s40272-021-00477-9. PMID: 34677814
Congenital, self-regressing tufted angioma.
Browning J, Frieden I, Baselga E, Wagner A, Metry D
Arch Dermatol 2006 Jun;142(6):749-51. doi: 10.1001/archderm.142.6.749. PMID: 16785378
Circumscribed choroidal hemangioma.
Mashayekhi A, Shields CL
Curr Opin Ophthalmol 2003 Jun;14(3):142-9. doi: 10.1097/00055735-200306000-00006. PMID: 12777933

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