U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sickle cell trait

MedGen UID:
20750
Concept ID:
C0037054
Disease or Syndrome
Synonyms: Cell Trait, Sickle; Cell Traits, Sickle; Sickle Cell Trait; Sickle Cell Traits; Trait, Sickle Cell; Traits, Sickle Cell
SNOMED CT: AS - Sickle cell trait (16402000); Heterozygous for Hb S (16402000); Drepanocytosis (16402000); RBC's - sickle cells present (16402000); Sickle cells present (16402000); Sickle cell trait (16402000); Hemoglobin S-A disorder (16402000); Hemoglobin A-S genotype (16402000); Hemoglobin S trait (16402000); Heterozygous hemoglobin S (16402000)

Definition

An individual who is heterozygous for the mutation that causes sickle cell anemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSickle cell trait

Professional guidelines

PubMed

Trpkov K, Hes O, Williamson SR, Adeniran AJ, Agaimy A, Alaghehbandan R, Amin MB, Argani P, Chen YB, Cheng L, Epstein JI, Cheville JC, Comperat E, da Cunha IW, Gordetsky JB, Gupta S, He H, Hirsch MS, Humphrey PA, Kapur P, Kojima F, Lopez JI, Maclean F, Magi-Galluzzi C, McKenney JK, Mehra R, Menon S, Netto GJ, Przybycin CG, Rao P, Rao Q, Reuter VE, Saleeb RM, Shah RB, Smith SC, Tickoo S, Tretiakova MS, True L, Verkarre V, Wobker SE, Zhou M, Gill AJ
Mod Pathol 2021 Jul;34(7):1392-1424. Epub 2021 Mar 4 doi: 10.1038/s41379-021-00779-w. PMID: 33664427
Reiner AP, Raffield LM, Franceschini N, Auer PL, Lange EM, Nickerson DA, Zakai NA, Correa A, Olson N; National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium; Natinal Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine Consortium
Clin J Am Soc Nephrol 2021 Feb 8;16(2):287-289. Epub 2020 Dec 2 doi: 10.2215/CJN.12100720. PMID: 33268503Free PMC Article
Francis YF
J Am Med Womens Assoc (1972) 1974 Sep;29(9):406-10. PMID: 4370353

Curated

American College of Medical Genetics and Genomics, Carrier Screening ACT Sheet, Sickle Cell Carrier/Trait, 2023

ACMG ACT, Hemoglobin S/Beta Plus Thalassemia , 2023

ACMG Algorithm, FSA: Hemoglobin HbS/B+ Screening Result, 2023

ACMG Algorithm, FAS: Sickle Cell Trait Screening Result, 2023

Recent clinical studies

Etiology

Eichner ER
Curr Sports Med Rep 2016 Nov/Dec;15(6):378-379. doi: 10.1249/JSR.0000000000000311. PMID: 27841805
Tubman VN, Field JJ
Hematology Am Soc Hematol Educ Program 2015;2015:433-5. doi: 10.1182/asheducation-2015.1.433. PMID: 26637754
Golomb MR
Arch Neurol 2005 Nov;62(11):1778-1779. doi: 10.1001/archneur.62.11.1778. PMID: 16286556
Kark JA, Ward FT
Semin Hematol 1994 Jul;31(3):181-225. PMID: 7973777
Nolte JA, Kleine JW
Acta Anaesthesiol Belg 1976;27(4):237-46. PMID: 800923

Diagnosis

Skinner S, Pialoux V, Fromy B, Sigaudo-Roussel D, Connes P
Lancet Diabetes Endocrinol 2018 Nov;6(11):840-843. Epub 2018 Feb 17 doi: 10.1016/S2213-8587(18)30033-0. PMID: 29459113
Naik RP, Haywood C Jr
Hematology Am Soc Hematol Educ Program 2015;2015(1):160-7. doi: 10.1182/asheducation-2015.1.160. PMID: 26637716Free PMC Article
Driscoll MC
Pediatr Rev 2007 Jul;28(7):259-68. doi: 10.1542/pir.28-7-259. PMID: 17601938
Kneut C
Issues Compr Pediatr Nurs 1980 Dec;4(5-6):19-27. doi: 10.3109/01460868009009786. PMID: 6909203
McCurdy PR
Am Fam Physician 1974 Nov;10(5):141-6. PMID: 4421745

Therapy

Ateba FF, Doumbia S, Ter Kuile FO, Terlouw DJ, Lefebvre G, Kariuki S, Small DS
Trans R Soc Trop Med Hyg 2021 Sep 3;115(9):1094-1098. doi: 10.1093/trstmh/traa183. PMID: 33493346Free PMC Article
Eichner ER
Curr Sports Med Rep 2017 Jan/Feb;16(1):2-3. doi: 10.1249/JSR.0000000000000328. PMID: 28067730
Driscoll MC
Pediatr Rev 2007 Jul;28(7):259-68. doi: 10.1542/pir.28-7-259. PMID: 17601938
Vichinsky EP, Lubin BH
Pediatr Clin North Am 1980 May;27(2):429-47. doi: 10.1016/s0031-3955(16)33860-3. PMID: 6155657
McCurdy PR
Am Fam Physician 1974 Nov;10(5):141-6. PMID: 4421745

Prognosis

Maier AG, Matuschewski K, Zhang M, Rug M
Trends Parasitol 2019 Jun;35(6):481-482. Epub 2018 Dec 27 doi: 10.1016/j.pt.2018.11.010. PMID: 30595467
Misra I, Glasgow J, Moosavy F
Del Med J 2017 May;89(5):148-150. PMID: 29894029
Eichner ER
Curr Sports Med Rep 2016 Nov/Dec;15(6):378-379. doi: 10.1249/JSR.0000000000000311. PMID: 27841805
Driscoll MC
Pediatr Rev 2007 Jul;28(7):259-68. doi: 10.1542/pir.28-7-259. PMID: 17601938
Nolte JA, Kleine JW
Acta Anaesthesiol Belg 1976;27(4):237-46. PMID: 800923

Clinical prediction guides

Hoogenboom WS, Fleysher R, Soby S, Mirhaji P, Mitchell WB, Morrone KA, Manwani D, Duong TQ
Haematologica 2021 Nov 1;106(11):3014-3016. doi: 10.3324/haematol.2021.279222. PMID: 34348452Free PMC Article
Muriuki JM, Mentzer AJ, Mitchell R, Webb EL, Etyang AO, Kyobutungi C, Morovat A, Kimita W, Ndungu FM, Macharia AW, Ngetsa CJ, Makale J, Lule SA, Musani SK, Raffield LM, Cutland CL, Sirima SB, Diarra A, Tiono AB, Fried M, Gwamaka M, Adu-Afarwuah S, Wirth JP, Wegmüller R, Madhi SA, Snow RW, Hill AVS, Rockett KA, Sandhu MS, Kwiatkowski DP, Prentice AM, Byrd KA, Ndjebayi A, Stewart CP, Engle-Stone R, Green TJ, Karakochuk CD, Suchdev PS, Bejon P, Duffy PE, Davey Smith G, Elliott AM, Williams TN, Atkinson SH
Nat Med 2021 Apr;27(4):653-658. Epub 2021 Feb 22 doi: 10.1038/s41591-021-01238-4. PMID: 33619371Free PMC Article
Elliott A, Bruner E
Arch Pathol Lab Med 2019 Dec;143(12):1556-1561. Epub 2019 Mar 11 doi: 10.5858/arpa.2017-0492-RS. PMID: 30855171
Eichner ER
Curr Sports Med Rep 2017 Jan/Feb;16(1):2-3. doi: 10.1249/JSR.0000000000000328. PMID: 28067730
Gong L, Parikh S, Rosenthal PJ, Greenhouse B
Malar J 2013 Sep 11;12:317. doi: 10.1186/1475-2875-12-317. PMID: 24025776Free PMC Article

Recent systematic reviews

Woreta FA, Lindsley KB, Gharaibeh A, Ng SM, Scherer RW, Goldberg MF
Cochrane Database Syst Rev 2023 Mar 13;3(3):CD005431. doi: 10.1002/14651858.CD005431.pub5. PMID: 36912744Free PMC Article
Abu-Shaheen A, Dahan D, Henaa H, Nofal A, Abdelmoety DA, Riaz M, AlSheef M, Almatary A, AlFayyad I
Expert Rev Hematol 2022 Oct;15(10):893-909. Epub 2022 Oct 18 doi: 10.1080/17474086.2022.2132225. PMID: 36217841
Naik RP, Smith-Whitley K, Hassell KL, Umeh NI, de Montalembert M, Sahota P, Haywood C Jr, Jenkins J, Lloyd-Puryear MA, Joiner CH, Bonham VL, Kato GJ
Ann Intern Med 2018 Nov 6;169(9):619-627. Epub 2018 Oct 30 doi: 10.7326/M18-1161. PMID: 30383109Free PMC Article
Alvarez O, Rodriguez MM, Jordan L, Sarnaik S
Pediatr Blood Cancer 2015 Oct;62(10):1694-9. Epub 2015 Jun 5 doi: 10.1002/pbc.25592. PMID: 26053587
Owusu ED, Visser BJ, Nagel IM, Mens PF, Grobusch MP
Clin Infect Dis 2015 Feb 15;60(4):612-26. Epub 2014 Oct 23 doi: 10.1093/cid/ciu832. PMID: 25344542

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • ACMG ACT, 2023
      American College of Medical Genetics and Genomics, Carrier Screening ACT Sheet, Sickle Cell Carrier/Trait, 2023
    • ACMG ACT, 2023
      ACMG ACT, Hemoglobin S/Beta Plus Thalassemia , 2023
    • ACMG Algorithm, 2023
      ACMG Algorithm, FSA: Hemoglobin HbS/B+ Screening Result, 2023
    • ACMG Algorithm, 2023
      ACMG Algorithm, FAS: Sickle Cell Trait Screening Result, 2023

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...