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Decreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio

MedGen UID:
1814114
Concept ID:
C5558379
Finding
HPO: HP:0034006

Definition

A decreased amount of the urinary cross-links lysyl-pyridinoline (LP, or deoxypyridinoline DPD) as compared to hydroxylysyl-pyridinoline (HP, or pyridinoline PYD). Both are established biochemical markers of osteoclastic bone resorption and collagen degradation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased urinary lysyl-pyridinoline-hydroxylysyl-pyridinoline ratio

Conditions with this feature

Ehlers-Danlos syndrome, kyphoscoliotic type 1
MedGen UID:
75672
Concept ID:
C0268342
Disease or Syndrome
PLOD1-related kyphoscoliotic Ehlers-Danlos syndrome (PLOD1-kEDS) is characterized by hypotonia, generalized joint hypermobility, early-onset kyphoscoliosis, skin fragility, and ocular abnormality. Intelligence is normal. Life span may be normal, but affected individuals are at risk of life-threatening arterial ruptures and spontaneous dissections of medium-sized arteries. Adults with severe kyphoscoliosis are at risk for complications from restrictive lung disease, recurrent pneumonia, and cardiac failure.

Professional guidelines

PubMed

Csikós E, Horváth A, Ács K, Papp N, Balázs VL, Dolenc MS, Kenda M, Kočevar Glavač N, Nagy M, Protti M, Mercolini L, Horváth G, Farkas Á, On Behalf Of The Oemonom
Molecules 2021 Nov 25;26(23) doi: 10.3390/molecules26237141. PMID: 34885733Free PMC Article
Anim-Somuah M, Smyth RM, Cyna AM, Cuthbert A
Cochrane Database Syst Rev 2018 May 21;5(5):CD000331. doi: 10.1002/14651858.CD000331.pub4. PMID: 29781504Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250

Recent clinical studies

Etiology

Scaglione MA, Allshouse AA, Canfield DR, Mclaughlin HD, Bruno AM, Hammad IA, Branch DW, Maurer KA, Dood RL, Debbink MP, Silver RM, Einerson BD
Obstet Gynecol 2022 Nov 1;140(5):806-811. Epub 2022 Oct 5 doi: 10.1097/AOG.0000000000004957. PMID: 36201777Free PMC Article
Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Tyson AF, Campbell EF, Spangler LR, Ross SW, Reinke CE, Passaretti CL, Sing RF
J Intensive Care Med 2020 Aug;35(8):738-744. Epub 2018 Jun 10 doi: 10.1177/0885066618781304. PMID: 29886788
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250
Ashton-Miller JA, DeLancey JO
Ann N Y Acad Sci 2007 Apr;1101:266-96. Epub 2007 Apr 7 doi: 10.1196/annals.1389.034. PMID: 17416924

Diagnosis

Balasubramanian P, Wanner C, Ferreira JP, Ofstad AP, Elsaesser A, Zinman B, Inzucchi SE
J Clin Endocrinol Metab 2022 Jun 16;107(7):e3003-e3007. doi: 10.1210/clinem/dgac154. PMID: 35290464Free PMC Article
Kjaergaard AD, Teumer A, Witte DR, Stanzick KJ, Winkler TW, Burgess S, Ellervik C
Clin Chem 2022 Mar 4;68(3):461-472. doi: 10.1093/clinchem/hvab249. PMID: 34922334Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250
de Boer A, Hoogduin JM, Blankestijn PJ, Li X, Luijten PR, Metzger GJ, Raaijmakers AJ, Umutlu L, Visser F, Leiner T
MAGMA 2016 Jun;29(3):417-33. Epub 2016 Mar 23 doi: 10.1007/s10334-016-0538-3. PMID: 27008461Free PMC Article
Bent S, Nallamothu BK, Simel DL, Fihn SD, Saint S
JAMA 2002 May 22-29;287(20):2701-10. doi: 10.1001/jama.287.20.2701. PMID: 12020306

Therapy

Bapir R, Bhatti KH, Eliwa A, García-Perdomo HA, Gherabi N, Hennessey D, Magri V, Mourmouris P, Ouattara A, Perletti G, Philipraj J, Stamatiou K, Tolani MA, Tzelves L, Trinchieri A, Buchholz N
Arch Ital Urol Androl 2023 Oct 4;95(3):11718. doi: 10.4081/aiua.2023.11718. PMID: 37791545
Carvalho PEP, Veiga TMA, Simões E Silva AC, Gewehr DM, Dagostin CS, Fernandes A, Nasi G, Cardoso R
Clin Res Cardiol 2023 Aug;112(8):1044-1055. Epub 2023 Jan 2 doi: 10.1007/s00392-022-02148-2. PMID: 36592186Free PMC Article
Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250
Woodley SJ, Boyle R, Cody JD, Mørkved S, Hay-Smith EJC
Cochrane Database Syst Rev 2017 Dec 22;12(12):CD007471. doi: 10.1002/14651858.CD007471.pub3. PMID: 29271473Free PMC Article

Prognosis

Zhou Z, Xiong L, Yao K, Ma H, Wei W, Zhang Z, Guo S, Dong P, Li X, Jiang L, Chen D, Qin Z, Han H, Ye Y, Li Y, Wang Y, Wu Z, Tian L, Yu C, Zhou F, Li Z, Liu Z
Cell Rep Med 2024 Jan 16;5(1):101343. Epub 2023 Dec 27 doi: 10.1016/j.xcrm.2023.101343. PMID: 38154462Free PMC Article
Robertson D, Ng SK, Baade PD, Lam AK
Int J Colorectal Dis 2022 Mar;37(3):541-551. Epub 2022 Feb 12 doi: 10.1007/s00384-022-04105-x. PMID: 35152308Free PMC Article
Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250
Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Garabet L, Salmon JE
Ann Intern Med 2015 Aug 4;163(3):153-63. doi: 10.7326/M14-2235. PMID: 26098843Free PMC Article

Clinical prediction guides

Haines RW, Fowler AJ, Liang K, Pearse RM, Larsson AO, Puthucheary Z, Prowle JR
Clin J Am Soc Nephrol 2023 Aug 1;18(8):997-1005. Epub 2023 May 31 doi: 10.2215/CJN.0000000000000203. PMID: 37256861Free PMC Article
Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Babar A, Moore L, Leblanc V, Dudonné S, Desjardins Y, Lemieux S, Bochard V, Guyonnet D, Dodin S
BMC Urol 2021 Mar 23;21(1):44. doi: 10.1186/s12894-021-00811-w. PMID: 33757474Free PMC Article
Kuppermann N, Dayan PS, Levine DA, Vitale M, Tzimenatos L, Tunik MG, Saunders M, Ruddy RM, Roosevelt G, Rogers AJ, Powell EC, Nigrovic LE, Muenzer J, Linakis JG, Grisanti K, Jaffe DM, Hoyle JD Jr, Greenberg R, Gattu R, Cruz AT, Crain EF, Cohen DM, Brayer A, Borgialli D, Bonsu B, Browne L, Blumberg S, Bennett JE, Atabaki SM, Anders J, Alpern ER, Miller B, Casper TC, Dean JM, Ramilo O, Mahajan P; Febrile Infant Working Group of the Pediatric Emergency Care Applied Research Network (PECARN)
JAMA Pediatr 2019 Apr 1;173(4):342-351. doi: 10.1001/jamapediatrics.2018.5501. PMID: 30776077Free PMC Article
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250

Recent systematic reviews

Pickett CM, Seeratan DD, Mol BWJ, Nieboer TE, Johnson N, Bonestroo T, Aarts JW
Cochrane Database Syst Rev 2023 Aug 29;8(8):CD003677. doi: 10.1002/14651858.CD003677.pub6. PMID: 37642285Free PMC Article
Xia JY, Yang C, Xu DF, Xia H, Yang LG, Sun GJ
PLoS One 2021;16(9):e0256992. Epub 2021 Sep 2 doi: 10.1371/journal.pone.0256992. PMID: 34473789Free PMC Article
Woodley SJ, Lawrenson P, Boyle R, Cody JD, Mørkved S, Kernohan A, Hay-Smith EJC
Cochrane Database Syst Rev 2020 May 6;5(5):CD007471. doi: 10.1002/14651858.CD007471.pub4. PMID: 32378735Free PMC Article
Anim-Somuah M, Smyth RM, Cyna AM, Cuthbert A
Cochrane Database Syst Rev 2018 May 21;5(5):CD000331. doi: 10.1002/14651858.CD000331.pub4. PMID: 29781504Free PMC Article
Woodley SJ, Boyle R, Cody JD, Mørkved S, Hay-Smith EJC
Cochrane Database Syst Rev 2017 Dec 22;12(12):CD007471. doi: 10.1002/14651858.CD007471.pub3. PMID: 29271473Free PMC Article

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