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Refractory Acute Myeloid Leukemia, Myelodysplasia-Related

MedGen UID:
1793142
•Concept ID:
C5556701
•
Neoplastic Process
Synonym: Refractory Acute Myeloid Leukemia with Myelodysplasia-Related Changes

Definition

Acute myeloid leukemia, myelodysplasia-related that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Acute Myeloid Leukemia, Myelodysplasia-Related

Professional guidelines

PubMed

The WHO 2016 diagnostic criteria for Acute Myeloid leukemia with myelodysplasia related changes (AML-MRC) produce a very heterogeneous entity: A retrospective analysis of the FAB subtype RAEB-T.
Kaivers J, Peters J, Rautenberg C, Schroeder T, Kobbe G, Hildebrandt B, Haas R, Germing U, Bennett JM
Leuk Res 2022 Jan;112:106757. Epub 2021 Nov 26 doi: 10.1016/j.leukres.2021.106757. PMID: 34864369
Advances in the prognostication and management of advanced MDS in children.
Hasle H, Niemeyer CM
Br J Haematol 2011 Jul;154(2):185-95. Epub 2011 May 9 doi: 10.1111/j.1365-2141.2011.08724.x. PMID: 21554264

Recent clinical studies

Etiology

Dismal outcome of refractory or relapsing patients with myelodysplasia-related acute myeloid leukemia partially alleviated by intensive chemotherapy.
Leroy H, Gadaud N, Bérard E, Klein E, Luquet I, Vial JP, Rieu JB, Lechevalier N, Tavitian S, Leguay T, Largeaud L, Bidet A, Delabesse E, Sarry A, de Grande AC, Récher C, Pigneux A, Bertoli S, Dumas PY
Cancer Med 2024 Feb;13(3):e7003. doi: 10.1002/cam4.7003. PMID: 38400682Free PMC Article
A retrospective assessment of real-world experience with venetoclax and azacitidine therapy in elderly acute myeloid leukemia.
Hu RH, Su L, Lan XX, Chang XL, Hui WH, Guo YX, Zhao H, Zhang Y, Sun WL
Anticancer Drugs 2023 Mar 1;34(3):344-350. Epub 2022 Nov 17 doi: 10.1097/CAD.0000000000001431. PMID: 36622759Free PMC Article
The WHO 2016 diagnostic criteria for Acute Myeloid leukemia with myelodysplasia related changes (AML-MRC) produce a very heterogeneous entity: A retrospective analysis of the FAB subtype RAEB-T.
Kaivers J, Peters J, Rautenberg C, Schroeder T, Kobbe G, Hildebrandt B, Haas R, Germing U, Bennett JM
Leuk Res 2022 Jan;112:106757. Epub 2021 Nov 26 doi: 10.1016/j.leukres.2021.106757. PMID: 34864369
Occurrence of acute myeloid leukemia in hydroxyurea-treated sickle cell disease patient.
Regan S, Yang X, Finnberg NK, El-Deiry WS, Pu JJ
Cancer Biol Ther 2019;20(11):1389-1397. Epub 2019 Aug 18 doi: 10.1080/15384047.2019.1647055. PMID: 31423878Free PMC Article
Recent advances in the diagnosis and classification of myeloid neoplasms--comments on the 2008 WHO classification.
Yin CC, Medeiros LJ, Bueso-Ramos CE
Int J Lab Hematol 2010 Oct;32(5):461-76. Epub 2010 Jul 7 doi: 10.1111/j.1751-553X.2010.01246.x. PMID: 20626469Free PMC Article

Diagnosis

The WHO 2016 diagnostic criteria for Acute Myeloid leukemia with myelodysplasia related changes (AML-MRC) produce a very heterogeneous entity: A retrospective analysis of the FAB subtype RAEB-T.
Kaivers J, Peters J, Rautenberg C, Schroeder T, Kobbe G, Hildebrandt B, Haas R, Germing U, Bennett JM
Leuk Res 2022 Jan;112:106757. Epub 2021 Nov 26 doi: 10.1016/j.leukres.2021.106757. PMID: 34864369
New drugs creating new challenges in acute myeloid leukemia.
Tiong IS, Wei AH
Genes Chromosomes Cancer 2019 Dec;58(12):903-914. Epub 2019 Apr 11 doi: 10.1002/gcc.22750. PMID: 30861214
New and emerging therapies for acute myeloid leukaemia.
Davis JR, Benjamin DJ, Jonas BA
J Investig Med 2018 Dec;66(8):1088-1095. Epub 2018 Aug 19 doi: 10.1136/jim-2018-000807. PMID: 30127098Free PMC Article
Advances in the prognostication and management of advanced MDS in children.
Hasle H, Niemeyer CM
Br J Haematol 2011 Jul;154(2):185-95. Epub 2011 May 9 doi: 10.1111/j.1365-2141.2011.08724.x. PMID: 21554264
Recent advances in the diagnosis and classification of myeloid neoplasms--comments on the 2008 WHO classification.
Yin CC, Medeiros LJ, Bueso-Ramos CE
Int J Lab Hematol 2010 Oct;32(5):461-76. Epub 2010 Jul 7 doi: 10.1111/j.1751-553X.2010.01246.x. PMID: 20626469Free PMC Article

Therapy

Dismal outcome of refractory or relapsing patients with myelodysplasia-related acute myeloid leukemia partially alleviated by intensive chemotherapy.
Leroy H, Gadaud N, Bérard E, Klein E, Luquet I, Vial JP, Rieu JB, Lechevalier N, Tavitian S, Leguay T, Largeaud L, Bidet A, Delabesse E, Sarry A, de Grande AC, Récher C, Pigneux A, Bertoli S, Dumas PY
Cancer Med 2024 Feb;13(3):e7003. doi: 10.1002/cam4.7003. PMID: 38400682Free PMC Article
A retrospective assessment of real-world experience with venetoclax and azacitidine therapy in elderly acute myeloid leukemia.
Hu RH, Su L, Lan XX, Chang XL, Hui WH, Guo YX, Zhao H, Zhang Y, Sun WL
Anticancer Drugs 2023 Mar 1;34(3):344-350. Epub 2022 Nov 17 doi: 10.1097/CAD.0000000000001431. PMID: 36622759Free PMC Article
New drugs creating new challenges in acute myeloid leukemia.
Tiong IS, Wei AH
Genes Chromosomes Cancer 2019 Dec;58(12):903-914. Epub 2019 Apr 11 doi: 10.1002/gcc.22750. PMID: 30861214
New and emerging therapies for acute myeloid leukaemia.
Davis JR, Benjamin DJ, Jonas BA
J Investig Med 2018 Dec;66(8):1088-1095. Epub 2018 Aug 19 doi: 10.1136/jim-2018-000807. PMID: 30127098Free PMC Article
Advances in the prognostication and management of advanced MDS in children.
Hasle H, Niemeyer CM
Br J Haematol 2011 Jul;154(2):185-95. Epub 2011 May 9 doi: 10.1111/j.1365-2141.2011.08724.x. PMID: 21554264

Prognosis

Dismal outcome of refractory or relapsing patients with myelodysplasia-related acute myeloid leukemia partially alleviated by intensive chemotherapy.
Leroy H, Gadaud N, Bérard E, Klein E, Luquet I, Vial JP, Rieu JB, Lechevalier N, Tavitian S, Leguay T, Largeaud L, Bidet A, Delabesse E, Sarry A, de Grande AC, Récher C, Pigneux A, Bertoli S, Dumas PY
Cancer Med 2024 Feb;13(3):e7003. doi: 10.1002/cam4.7003. PMID: 38400682Free PMC Article
A retrospective assessment of real-world experience with venetoclax and azacitidine therapy in elderly acute myeloid leukemia.
Hu RH, Su L, Lan XX, Chang XL, Hui WH, Guo YX, Zhao H, Zhang Y, Sun WL
Anticancer Drugs 2023 Mar 1;34(3):344-350. Epub 2022 Nov 17 doi: 10.1097/CAD.0000000000001431. PMID: 36622759Free PMC Article
The WHO 2016 diagnostic criteria for Acute Myeloid leukemia with myelodysplasia related changes (AML-MRC) produce a very heterogeneous entity: A retrospective analysis of the FAB subtype RAEB-T.
Kaivers J, Peters J, Rautenberg C, Schroeder T, Kobbe G, Hildebrandt B, Haas R, Germing U, Bennett JM
Leuk Res 2022 Jan;112:106757. Epub 2021 Nov 26 doi: 10.1016/j.leukres.2021.106757. PMID: 34864369
New and emerging therapies for acute myeloid leukaemia.
Davis JR, Benjamin DJ, Jonas BA
J Investig Med 2018 Dec;66(8):1088-1095. Epub 2018 Aug 19 doi: 10.1136/jim-2018-000807. PMID: 30127098Free PMC Article
Advances in the prognostication and management of advanced MDS in children.
Hasle H, Niemeyer CM
Br J Haematol 2011 Jul;154(2):185-95. Epub 2011 May 9 doi: 10.1111/j.1365-2141.2011.08724.x. PMID: 21554264

Clinical prediction guides

Dismal outcome of refractory or relapsing patients with myelodysplasia-related acute myeloid leukemia partially alleviated by intensive chemotherapy.
Leroy H, Gadaud N, Bérard E, Klein E, Luquet I, Vial JP, Rieu JB, Lechevalier N, Tavitian S, Leguay T, Largeaud L, Bidet A, Delabesse E, Sarry A, de Grande AC, Récher C, Pigneux A, Bertoli S, Dumas PY
Cancer Med 2024 Feb;13(3):e7003. doi: 10.1002/cam4.7003. PMID: 38400682Free PMC Article
A retrospective assessment of real-world experience with venetoclax and azacitidine therapy in elderly acute myeloid leukemia.
Hu RH, Su L, Lan XX, Chang XL, Hui WH, Guo YX, Zhao H, Zhang Y, Sun WL
Anticancer Drugs 2023 Mar 1;34(3):344-350. Epub 2022 Nov 17 doi: 10.1097/CAD.0000000000001431. PMID: 36622759Free PMC Article
Azacitidine, intensive chemotherapy or best supportive care in relapsed or refractory acute myeloid leukemia, a DATAML registry study.
Gadaud N, Leroy H, Bérard E, Tavitian S, Leguay T, Dimicoli-Salazar S, Rieu JB, Luquet I, Largeaud L, Bidet A, Delabesse E, Klein E, Sarry A, de Grande AC, Bories P, Pigneux A, Récher C, Dumas PY, Bertoli S
Leuk Lymphoma 2022 Jun;63(6):1398-1406. Epub 2022 Jan 4 doi: 10.1080/10428194.2021.2022140. PMID: 35634787
Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndromes are associated with complex karyotype, monosomal karyotype, TP53 deletion, and TP53 mutations.
Wang N, Yuan L, Jing Y, Fan K, Jin H, Lv C, Wang L, Yu L
Leuk Lymphoma 2021 Oct;62(10):2466-2474. Epub 2021 Apr 27 doi: 10.1080/10428194.2021.1919663. PMID: 33904352
Impaired mitochondrial gene transcription in myelodysplastic syndromes and acute myeloid leukemia with myelodysplasia-related changes.
Schildgen V, Wulfert M, Gattermann N
Exp Hematol 2011 Jun;39(6):666-675.e1. Epub 2011 Mar 27 doi: 10.1016/j.exphem.2011.03.007. PMID: 21447369

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