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Breast Cellular Fibroadenoma

MedGen UID:
1781463
•Concept ID:
C5446940
•
Neoplastic Process

Definition

A fibroadenoma characterized by the presence of a pericanalicular growth pattern, increased stromal cellularity, and less than 2 mitoses per 10 high-power fields. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Cellular Fibroadenoma

Professional guidelines

PubMed

Fibroepithelial lesions revisited: implications for diagnosis and management.
Tan PH
Mod Pathol 2021 Jan;34(Suppl 1):15-37. Epub 2020 May 27 doi: 10.1038/s41379-020-0583-3. PMID: 32461622
Diagnosis and management of benign, atypical, and indeterminate breast lesions detected on core needle biopsy.
Neal L, Sandhu NP, Hieken TJ, Glazebrook KN, Mac Bride MB, Dilaveri CA, Wahner-Roedler DL, Ghosh K, Visscher DW
Mayo Clin Proc 2014 Apr;89(4):536-47. doi: 10.1016/j.mayocp.2014.02.004. PMID: 24684875
Breast cancer: new technologies for risk assessment and diagnosis.
Wright T, McGechan A
Mol Diagn 2003;7(1):49-55. doi: 10.1007/BF03260021. PMID: 14529321

Recent clinical studies

Etiology

Fibroadenoma in vulval ectopic breast tissue in a patient with PTEN Hamartoma Tumour Syndrome.
Dawson H, Smrke A, Ellery PM, Wilkinson N, Rosenthal AN, McVeigh TP
Fam Cancer 2022 Jul;21(3):363-368. Epub 2021 Sep 15 doi: 10.1007/s10689-021-00275-9. PMID: 34524588
Genetics and genomics of breast fibroadenomas.
Loke BN, Md Nasir ND, Thike AA, Lee JYH, Lee CS, Teh BT, Tan PH
J Clin Pathol 2018 May;71(5):381-387. Epub 2017 Dec 16 doi: 10.1136/jclinpath-2017-204838. PMID: 29248888
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Sarcomas of the breast.
Alabassi A, Fentiman IS
Int J Clin Pract 2003 Dec;57(10):886-9. PMID: 14712891

Diagnosis

Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Bilateral Diffuse Pseudoangiomatous Stromal Hyperplasia Necessitating Mastectomy.
Jones VM, Cairns A, Miller-Ocuin J, Steele T, Aguila-Seara G, Ghandili M, LeRoy Coldren D, Marks MW, Howard-McNatt M, Chiba A
Am Surg 2022 Aug;88(8):1919-1921. Epub 2022 Apr 17 doi: 10.1177/00031348221086811. PMID: 35435015
Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Fibroadenomas: a multidisciplinary review of the variants.
Basara Akin I, Balci P
Clin Imaging 2021 Mar;71:83-100. Epub 2020 Nov 6 doi: 10.1016/j.clinimag.2020.10.058. PMID: 33186871
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article

Therapy

Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Pseudoangiomatous stromal hyperplasia of the breast.
AbdullGaffar B
Arch Pathol Lab Med 2009 Aug;133(8):1335-8. doi: 10.5858/133.8.1335. PMID: 19653734
Sarcomas of the breast.
Alabassi A, Fentiman IS
Int J Clin Pract 2003 Dec;57(10):886-9. PMID: 14712891
Toward a physiological approach to breast cancer prevention.
Russo J, Russo IH
Cancer Epidemiol Biomarkers Prev 1994 Jun;3(4):353-64. PMID: 8061586
Breast adenomas.
Hertel BF, Zaloudek C, Kempson RL
Cancer 1976 Jun;37(6):2891-905. doi: 10.1002/1097-0142(197606)37:6<2891::aid-cncr2820370647>3.0.co;2-p. PMID: 949710

Prognosis

Fibroepithelial tumours of the breast-a review.
Lerwill MF, Lee AHS, Tan PH
Virchows Arch 2022 Jan;480(1):45-63. Epub 2021 Sep 10 doi: 10.1007/s00428-021-03175-6. PMID: 34505197
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Optimising preoperative diagnosis in phyllodes tumour of the breast.
Jacklin RK, Ridgway PF, Ziprin P, Healy V, Hadjiminas D, Darzi A
J Clin Pathol 2006 May;59(5):454-9. Epub 2006 Feb 6 doi: 10.1136/jcp.2005.025866. PMID: 16461806Free PMC Article
Sarcomas of the breast.
Alabassi A, Fentiman IS
Int J Clin Pract 2003 Dec;57(10):886-9. PMID: 14712891

Clinical prediction guides

Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets.
Chen Z, Zhang Y, Li W, Gao C, Huang F, Cheng L, Jin M, Xu X, Huang J
Nat Commun 2023 Jun 16;14(1):3469. doi: 10.1038/s41467-023-39059-3. PMID: 37328469Free PMC Article
Fibroepithelial lesions; The WHO spectrum.
Krings G, Bean GR, Chen YY
Semin Diagn Pathol 2017 Sep;34(5):438-452. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.006. PMID: 28688536
Phyllodes tumours of the breast: a consensus review.
Tan BY, Acs G, Apple SK, Badve S, Bleiweiss IJ, Brogi E, Calvo JP, Dabbs DJ, Ellis IO, Eusebi V, Farshid G, Fox SB, Ichihara S, Lakhani SR, Rakha EA, Reis-Filho JS, Richardson AL, Sahin A, Schmitt FC, Schnitt SJ, Siziopikou KP, Soares FA, Tse GM, Vincent-Salomon A, Tan PH
Histopathology 2016 Jan;68(1):5-21. doi: 10.1111/his.12876. PMID: 26768026Free PMC Article
Sarcomas of the breast.
Alabassi A, Fentiman IS
Int J Clin Pract 2003 Dec;57(10):886-9. PMID: 14712891
Fibro-adenoma of the breast.
Wilkinson S, Forrest AP
Br J Surg 1985 Oct;72(10):838-40. doi: 10.1002/bjs.1800721021. PMID: 4041718

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