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Recurrent Acute Myelomonocytic Leukemia

MedGen UID:
1712090
•Concept ID:
C2861599
•
Neoplastic Process
Synonym: Relapsed Acute Myelomonocytic Leukemia

Definition

The reemergence of acute myelomonocytic leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Myelomonocytic Leukemia

Professional guidelines

PubMed

Leukocytapheresis for the treatment of hyperleukocytosis secondary to acute leukemia.
Aqui N, O'Doherty U
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):457-60. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.457. PMID: 25696894
Efficacy of a 3-day, low-dose treatment with 5-azacytidine followed by donor lymphocyte infusions in older patients with acute myeloid leukemia or chronic myelomonocytic leukemia relapsed after allografting.
Lübbert M, Bertz H, Wäsch R, Marks R, Rüter B, Claus R, Finke J
Bone Marrow Transplant 2010 Apr;45(4):627-32. Epub 2009 Aug 31 doi: 10.1038/bmt.2009.222. PMID: 19718057
Gemtuzumab ozogamicin in the treatment of acute myeloid leukemia.
Giles F, Estey E, O'Brien S
Cancer 2003 Nov 15;98(10):2095-104. doi: 10.1002/cncr.11791. PMID: 14601078

Recent clinical studies

Etiology

10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Extramedullary Manifestations of Myeloid Neoplasms.
Wilson CS, Medeiros LJ
Am J Clin Pathol 2015 Aug;144(2):219-39. doi: 10.1309/AJCPO58YWIBUBESX. PMID: 26185307
Administration of mylotarg 4 days after beginning of a chemotherapy including intermediate-dose aracytin and mitoxantrone (MIDAM regimen) produces a high rate of complete hematologic remission in patients with CD33+ primary resistant or relapsed acute myeloid leukemia.
Chevallier P, Roland V, Mahé B, Juge-Morineau N, Dubruille V, Guillaume T, Vigouroux S, Moreau P, Milpied N, Garand R, Avet-Loiseau H, Harousseau JL
Leuk Res 2005 Sep;29(9):1003-7. Epub 2005 Apr 8 doi: 10.1016/j.leukres.2005.02.005. PMID: 16038726
Acute leukaemia in Jehovah's Witnesses.
Cullis JO, Duncombe AS, Dudley JM, Lumley HS, Apperley JF, Smith AG
Br J Haematol 1998 Mar;100(4):664-8. doi: 10.1046/j.1365-2141.1998.00634.x. PMID: 9531331
Spontaneous remission of congenital leukemia.
Dinulos JG, Hawkins DS, Clark BS, Francis JS
J Pediatr 1997 Aug;131(2):300-3. doi: 10.1016/s0022-3476(97)70170-7. PMID: 9290620

Diagnosis

Progression in Myeloid Neoplasms: Beyond the Myeloblast.
Faria C, Tzankov A
Pathobiology 2024;91(1):55-75. Epub 2023 May 11 doi: 10.1159/000530940. PMID: 37232015Free PMC Article
10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Orbital myxoma comorbid with acute myelomonocytic leukemia.
Mupas-Uy J, Kitaguchi Y, Takahashi Y, Takahashi E, Kakizaki H
Orbit 2017 Dec;36(6):465-467. Epub 2017 Aug 16 doi: 10.1080/01676830.2017.1337196. PMID: 28812920
Survival ensembles.
Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ
Biostatistics 2006 Jul;7(3):355-73. Epub 2005 Dec 12 doi: 10.1093/biostatistics/kxj011. PMID: 16344280
Acute myeloid leukemia.
Löwenberg B, Downing JR, Burnett A
N Engl J Med 1999 Sep 30;341(14):1051-62. doi: 10.1056/NEJM199909303411407. PMID: 10502596

Therapy

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.
Sango J, Carcamo S, Sirenko M, Maiti A, Mansour H, Ulukaya G, Tomalin LE, Cruz-Rodriguez N, Wang T, Olszewska M, Olivier E, Jaud M, Nadorp B, Kroger B, Hu F, Silverman L, Chung SS, Wagenblast E, Chaligne R, Eisfeld AK, Demircioglu D, Landau DA, Lito P, Papaemmanuil E, DiNardo CD, Hasson D, Konopleva M, Papapetrou EP
Nature 2024 Dec;636(8041):241-250. Epub 2024 Oct 30 doi: 10.1038/s41586-024-08137-x. PMID: 39478230Free PMC Article
10-day decitabine with venetoclax for newly diagnosed intensive chemotherapy ineligible, and relapsed or refractory acute myeloid leukaemia: a single-centre, phase 2 trial.
DiNardo CD, Maiti A, Rausch CR, Pemmaraju N, Naqvi K, Daver NG, Kadia TM, Borthakur G, Ohanian M, Alvarado Y, Issa GC, Montalban-Bravo G, Short NJ, Yilmaz M, Bose P, Jabbour EJ, Takahashi K, Burger JA, Garcia-Manero G, Jain N, Kornblau SM, Thompson PA, Estrov Z, Masarova L, Sasaki K, Verstovsek S, Ferrajoli A, Weirda WG, Wang SA, Konoplev S, Chen Z, Pierce SA, Ning J, Qiao W, Ravandi F, Andreeff M, Welch JS, Kantarjian HM, Konopleva MY
Lancet Haematol 2020 Oct;7(10):e724-e736. Epub 2020 Sep 5 doi: 10.1016/S2352-3026(20)30210-6. PMID: 32896301Free PMC Article
Survival ensembles.
Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ
Biostatistics 2006 Jul;7(3):355-73. Epub 2005 Dec 12 doi: 10.1093/biostatistics/kxj011. PMID: 16344280
Acute myeloid leukemia.
Löwenberg B, Downing JR, Burnett A
N Engl J Med 1999 Sep 30;341(14):1051-62. doi: 10.1056/NEJM199909303411407. PMID: 10502596
Spontaneous remission of congenital leukemia.
Dinulos JG, Hawkins DS, Clark BS, Francis JS
J Pediatr 1997 Aug;131(2):300-3. doi: 10.1016/s0022-3476(97)70170-7. PMID: 9290620

Prognosis

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.
Sango J, Carcamo S, Sirenko M, Maiti A, Mansour H, Ulukaya G, Tomalin LE, Cruz-Rodriguez N, Wang T, Olszewska M, Olivier E, Jaud M, Nadorp B, Kroger B, Hu F, Silverman L, Chung SS, Wagenblast E, Chaligne R, Eisfeld AK, Demircioglu D, Landau DA, Lito P, Papaemmanuil E, DiNardo CD, Hasson D, Konopleva M, Papapetrou EP
Nature 2024 Dec;636(8041):241-250. Epub 2024 Oct 30 doi: 10.1038/s41586-024-08137-x. PMID: 39478230Free PMC Article
Somatic SETBP1 mutations in myeloid neoplasms.
Makishima H
Int J Hematol 2017 Jun;105(6):732-742. Epub 2017 Apr 26 doi: 10.1007/s12185-017-2241-1. PMID: 28447248
Survival ensembles.
Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ
Biostatistics 2006 Jul;7(3):355-73. Epub 2005 Dec 12 doi: 10.1093/biostatistics/kxj011. PMID: 16344280
Acute myeloid leukemia.
Löwenberg B, Downing JR, Burnett A
N Engl J Med 1999 Sep 30;341(14):1051-62. doi: 10.1056/NEJM199909303411407. PMID: 10502596
Spontaneous remission of congenital leukemia.
Dinulos JG, Hawkins DS, Clark BS, Francis JS
J Pediatr 1997 Aug;131(2):300-3. doi: 10.1016/s0022-3476(97)70170-7. PMID: 9290620

Clinical prediction guides

RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.
Sango J, Carcamo S, Sirenko M, Maiti A, Mansour H, Ulukaya G, Tomalin LE, Cruz-Rodriguez N, Wang T, Olszewska M, Olivier E, Jaud M, Nadorp B, Kroger B, Hu F, Silverman L, Chung SS, Wagenblast E, Chaligne R, Eisfeld AK, Demircioglu D, Landau DA, Lito P, Papaemmanuil E, DiNardo CD, Hasson D, Konopleva M, Papapetrou EP
Nature 2024 Dec;636(8041):241-250. Epub 2024 Oct 30 doi: 10.1038/s41586-024-08137-x. PMID: 39478230Free PMC Article
CSF3R mutated myeloid neoplasms: Beyond chronic neutrophilic leukemia.
Mohamed A, Gao J, Chen YH, Abaza Y, Altman J, Jennings L, Vormittag-Nocito E, Sukhanova M, Lu X, Chen Q
Hum Pathol 2024 Jul;149:66-74. Epub 2024 Jun 13 doi: 10.1016/j.humpath.2024.06.008. PMID: 38879086
Acute myeloid leukemia with t(8;16)(p11.2;p13.3)/KAT6A-CREBBP in adults.
Xie W, Hu S, Xu J, Chen Z, Medeiros LJ, Tang G
Ann Hematol 2019 May;98(5):1149-1157. Epub 2019 Feb 13 doi: 10.1007/s00277-019-03637-7. PMID: 30759270
Survival ensembles.
Hothorn T, Bühlmann P, Dudoit S, Molinaro A, van der Laan MJ
Biostatistics 2006 Jul;7(3):355-73. Epub 2005 Dec 12 doi: 10.1093/biostatistics/kxj011. PMID: 16344280
Tetrasomy 21 as a sole chromosome abnormality in acute myeloid leukemia. fluorescence in situ hybridization and spectral karyotyping analyses.
Ohsaka A, Hisa T, Watanabe N, Kojima H, Nagasawa T
Cancer Genet Cytogenet 2002 Apr 1;134(1):60-4. doi: 10.1016/s0165-4608(01)00604-5. PMID: 11996798

Recent systematic reviews

Myeloid neoplasms with t(12;22)(p13;q12)/MN1-EVT6: a systematic review of 12 cases.
Shao H, Cen J, Chen S, Qiu H, Pan J
Ann Hematol 2018 Mar;97(3):417-424. Epub 2017 Dec 22 doi: 10.1007/s00277-017-3208-2. PMID: 29273914

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