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Elevated cancer Ag 19-9 level

MedGen UID:
1706180
Concept ID:
C5139284
Finding
HPO: HP:0032345

Definition

An abnormal increased in the amount of the carbohydrate antigen 19-9, a recognizable sialo-ganglioside in the blood circulation. [from HPO]

Term Hierarchy

Professional guidelines

PubMed

Sumiyoshi T, Uemura K, Shintakuya R, Okada K, Baba K, Harada T, Serikawa M, Ishii Y, Nakamura S, Arihiro K, Murakami Y, Takahashi S
Ann Surg Oncol 2024 Jul;31(7):4665-4672. Epub 2024 Apr 23 doi: 10.1245/s10434-024-15221-z. PMID: 38652196Free PMC Article
Tanaka H, Tamura K, Abe T, Yoshida T, Macgregor-Das A, Dbouk M, Blackford AL, Borges M, Lennon AM, He J, Burkhart R, Canto MI, Goggins M
Clin Gastroenterol Hepatol 2022 Oct;20(10):2267-2275.e2. Epub 2021 Oct 12 doi: 10.1016/j.cgh.2021.10.008. PMID: 34648951Free PMC Article
Su SB, Qin SY, Chen W, Luo W, Jiang HX
World J Gastroenterol 2015 Apr 14;21(14):4323-33. doi: 10.3748/wjg.v21.i14.4323. PMID: 25892884Free PMC Article

Recent clinical studies

Etiology

Chen Q, Yin H, Jiang Z, He T, Xie Y, Mao W, Han J, Liu S, Lou W, Wu W, Habib JR, Yu J, Liu L, Pu N
J Immunother Cancer 2024 Mar 26;12(3) doi: 10.1136/jitc-2023-008694. PMID: 38531664Free PMC Article
Yousef A, Yousef M, Zeineddine MA, More A, Fanaeian M, Chowdhury S, Knafl M, Edelkamp P, Ito I, Gu Y, Pattalachinti V, Naini ZA, Zeineddine FA, Peterson J, Alfaro K, Foo WC, Jin J, Bhutiani N, Higbie V, Scally CP, Kee B, Kopetz S, Goldstein D, Strach M, Williamson A, Aziz O, Barriuso J, Uppal A, White MG, Helmink B, Fournier KF, Raghav KP, Taggart MW, Overman MJ, Shen JP
JAMA Netw Open 2024 Feb 5;7(2):e240260. doi: 10.1001/jamanetworkopen.2024.0260. PMID: 38416491Free PMC Article
Boyev A, Prakash LR, Chiang YJ, Newhook TE, Bruno ML, Arvide EM, Dewhurst WL, Kim MP, Ikoma N, Lee JE, Snyder RA, Tzeng CD, Katz MHG, Maxwell JE
Surg Oncol 2023 Dec;51:101994. Epub 2023 Sep 19 doi: 10.1016/j.suronc.2023.101994. PMID: 37742542
Boyd LNC, Ali M, Comandatore A, Garajova I, Kam L, Puik JR, Fraga Rodrigues SM, Meijer LL, Le Large TYS, Besselink MG, Morelli L, Frampton A, van Laarhoven HWM, Giovannetti E, Kazemier G
JAMA Netw Open 2023 Aug 1;6(8):e2331197. doi: 10.1001/jamanetworkopen.2023.31197. PMID: 37639271Free PMC Article
Lee JO, Kim M, Lee JH, Kim Y, Lim HK, Kwon YH, Shin R, Park JW, Ryoo SB, Park KJ, Jeong SY
Colorectal Dis 2023 Feb;25(2):272-281. Epub 2022 Oct 27 doi: 10.1111/codi.16372. PMID: 36226485

Diagnosis

Tsen A, Barbara M, Rosenkranz L
Pancreatology 2018 Dec;18(8):862-867. Epub 2018 Sep 18 doi: 10.1016/j.pan.2018.09.004. PMID: 30249386
Buda N, Wszołek A, Śledziński M, Żawrocki A, Sworczak K
Korean J Intern Med 2018 Sep;33(5):1032-1033. Epub 2017 Oct 19 doi: 10.3904/kjim.2017.028. PMID: 29050465Free PMC Article
Scarà S, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:247-60. doi: 10.1007/978-94-017-7215-0_15. PMID: 26530370
Su SB, Qin SY, Chen W, Luo W, Jiang HX
World J Gastroenterol 2015 Apr 14;21(14):4323-33. doi: 10.3748/wjg.v21.i14.4323. PMID: 25892884Free PMC Article
Yamanishi H, Kumagi T, Yokota T, Koizumi M, Azemoto N, Watanabe J, Mizuno Y, Sugita A, Abe M, Ikeda Y, Matsuura B, Hiasa Y, Onji M
Intern Med 2011;50(18):1947-52. Epub 2011 Sep 15 doi: 10.2169/internalmedicine.50.5340. PMID: 21921374

Therapy

Nakisa A, Sempere LF, Chen X, Qu LT, Woldring D, Crawford HC, Huang X
ChemMedChem 2024 Dec 16;19(24):e202400491. Epub 2024 Nov 8 doi: 10.1002/cmdc.202400491. PMID: 39230966Free PMC Article
Lee W, Oh M, Kim JS, Sung M, Hong K, Kwak BJ, Park Y, Jun E, Song KB, Hwang DW, Lee JH, Yoo C, Kim KP, Park I, Jeong JH, Chang HM, Ryoo BY, Lee JB, Kim SC
Int J Surg 2024 Jul 1;110(7):4074-4082. doi: 10.1097/JS9.0000000000001389. PMID: 38537071Free PMC Article
Chao J, Wang S, Wang H, Zhang N, Wang Y, Yang X, Zhu C, Ning C, Zhang X, Xue J, Zhang L, Piao M, Wang M, Yang X, Lu L, Zhao H
Cancer Immunol Immunother 2023 Nov;72(11):3717-3726. Epub 2023 Oct 3 doi: 10.1007/s00262-023-03523-2. PMID: 37787790Free PMC Article
Su SB, Qin SY, Chen W, Luo W, Jiang HX
World J Gastroenterol 2015 Apr 14;21(14):4323-33. doi: 10.3748/wjg.v21.i14.4323. PMID: 25892884Free PMC Article
Li J, Zhao C, Shen Y
J Gastroenterol Hepatol 2012 Dec;27(12):1783-9. doi: 10.1111/j.1440-1746.2012.07287.x. PMID: 23034143

Prognosis

Chen Q, Yin H, Jiang Z, He T, Xie Y, Mao W, Han J, Liu S, Lou W, Wu W, Habib JR, Yu J, Liu L, Pu N
J Immunother Cancer 2024 Mar 26;12(3) doi: 10.1136/jitc-2023-008694. PMID: 38531664Free PMC Article
Lee JO, Kim M, Lee JH, Kim Y, Lim HK, Kwon YH, Shin R, Park JW, Ryoo SB, Park KJ, Jeong SY
Colorectal Dis 2023 Feb;25(2):272-281. Epub 2022 Oct 27 doi: 10.1111/codi.16372. PMID: 36226485
Tsen A, Barbara M, Rosenkranz L
Pancreatology 2018 Dec;18(8):862-867. Epub 2018 Sep 18 doi: 10.1016/j.pan.2018.09.004. PMID: 30249386
Scarà S, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:247-60. doi: 10.1007/978-94-017-7215-0_15. PMID: 26530370
Su SB, Qin SY, Chen W, Luo W, Jiang HX
World J Gastroenterol 2015 Apr 14;21(14):4323-33. doi: 10.3748/wjg.v21.i14.4323. PMID: 25892884Free PMC Article

Clinical prediction guides

Chen Q, Yin H, Jiang Z, He T, Xie Y, Mao W, Han J, Liu S, Lou W, Wu W, Habib JR, Yu J, Liu L, Pu N
J Immunother Cancer 2024 Mar 26;12(3) doi: 10.1136/jitc-2023-008694. PMID: 38531664Free PMC Article
Boyd LNC, Ali M, Comandatore A, Garajova I, Kam L, Puik JR, Fraga Rodrigues SM, Meijer LL, Le Large TYS, Besselink MG, Morelli L, Frampton A, van Laarhoven HWM, Giovannetti E, Kazemier G
JAMA Netw Open 2023 Aug 1;6(8):e2331197. doi: 10.1001/jamanetworkopen.2023.31197. PMID: 37639271Free PMC Article
Al-Janabi AAHS, Tawfeeq EF
J Gastrointest Cancer 2017 Jun;48(2):148-150. doi: 10.1007/s12029-016-9855-z. PMID: 27402465
Scarà S, Bottoni P, Scatena R
Adv Exp Med Biol 2015;867:247-60. doi: 10.1007/978-94-017-7215-0_15. PMID: 26530370
Su SB, Qin SY, Chen W, Luo W, Jiang HX
World J Gastroenterol 2015 Apr 14;21(14):4323-33. doi: 10.3748/wjg.v21.i14.4323. PMID: 25892884Free PMC Article

Recent systematic reviews

Zeng D, Li B, Cheng N
Surg Today 2025 Feb;55(2):131-143. Epub 2024 Oct 18 doi: 10.1007/s00595-024-02948-1. PMID: 39424711
Karamya ZA, Kovács A, Illés D, Czakó B, Fazekas A, Farkas N, Hegyi P, Czakó L
BMC Gastroenterol 2024 Aug 21;24(1):278. doi: 10.1186/s12876-024-03367-9. PMID: 39169289Free PMC Article
Bresadola V, Pravisani R, Terrosu G, Risaliti A
Ann Ital Chir 2015 Jan-Feb;86(1):22-9. PMID: 25819406
Stillwell AP, Ho YH, Veitch C
World J Surg 2011 Mar;35(3):684-92. doi: 10.1007/s00268-010-0891-8. PMID: 21181473
Goonetilleke KS, Siriwardena AK
Eur J Surg Oncol 2007 Apr;33(3):266-70. Epub 2006 Nov 9 doi: 10.1016/j.ejso.2006.10.004. PMID: 17097848

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