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Decreased circulating glycerol level

MedGen UID:
1639424
•Concept ID:
C4703542
•
Finding
HPO: HP:0031794

Definition

A decrease below the normal concentration of glycerol in the blood. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased circulating glycerol level

Professional guidelines

PubMed

The Impact of Intra-Arterial Papaverine-Hydrochloride on Cerebral Metabolism and Oxygenation for Treatment of Delayed-Onset Post-Subarachnoid Hemorrhage Vasospasm.
Hosmann A, Wang WT, Dodier P, Bavinzski G, Engel A, Herta J, Plöchl W, Reinprecht A, Gruber A
Neurosurgery 2020 Sep 15;87(4):712-719. doi: 10.1093/neuros/nyz500. PMID: 31792510
Metabolism in adipose tissue in response to citalopram and trimipramine treatment--an in situ microdialysis study.
Flechtner-Mors M, Jenkinson CP, Alt A, Adler G, Ditschuneit HH
J Psychiatr Res 2008 Jun;42(7):578-86. Epub 2007 Aug 9 doi: 10.1016/j.jpsychires.2007.06.003. PMID: 17692337
Impact of 2 weeks high dose growth hormone treatment on basal and insulin stimulated substrate metabolism in humans.
Møller N, Møller J, Jørgensen JO, Ovesen P, Schmitz O, Alberti KG, Christiansen JS
Clin Endocrinol (Oxf) 1993 Nov;39(5):577-81. doi: 10.1111/j.1365-2265.1993.tb02412.x. PMID: 8252748

Recent clinical studies

Etiology

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
The effects of a thermogenic supplement on metabolic and hemodynamic variables and subjective mood states.
Prather JM, Florez CM, Vargas A, Soto B, Harrison A, Willoughby D, Tinsley G, Taylor L
J Int Soc Sports Nutr 2023 Dec;20(1):2185538. doi: 10.1080/15502783.2023.2185538. PMID: 36862833Free PMC Article
Menopause modulates the circulating metabolome: evidence from a prospective cohort study.
Karppinen JE, Törmäkangas T, Kujala UM, Sipilä S, Laukkanen J, Aukee P, Kovanen V, Laakkonen EK
Eur J Prev Cardiol 2022 Aug 5;29(10):1448-1459. doi: 10.1093/eurjpc/zwac060. PMID: 35930503
Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2.
Rosenson RS, Stafforini DM
J Lipid Res 2012 Sep;53(9):1767-82. Epub 2012 Jun 4 doi: 10.1194/jlr.R024190. PMID: 22665167Free PMC Article
Metabolic abnormalities in impaired glucose tolerance.
Gerich JE
Metabolism 1997 Dec;46(12 Suppl 1):40-3. doi: 10.1016/s0026-0495(97)90316-4. PMID: 9439558

Diagnosis

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Research progress of fibroblast growth factor 23 in acute kidney injury.
Zhang L, Qin W
Pediatr Nephrol 2023 Jul;38(7):2013-2022. Epub 2022 Nov 22 doi: 10.1007/s00467-022-05791-z. PMID: 36416954Free PMC Article
Effects of diet and hyperlipidemia on levels and distribution of circulating lysophosphatidic acid.
Kraemer MP, Mao G, Hammill C, Yan B, Li Y, Onono F, Smyth SS, Morris AJ
J Lipid Res 2019 Nov;60(11):1818-1828. Epub 2019 Sep 4 doi: 10.1194/jlr.M093096. PMID: 31484695Free PMC Article
Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates.
Jobgen WS, Fried SK, Fu WJ, Meininger CJ, Wu G
J Nutr Biochem 2006 Sep;17(9):571-88. Epub 2006 Jan 9 doi: 10.1016/j.jnutbio.2005.12.001. PMID: 16524713
Human fat cell lipolysis: biochemistry, regulation and clinical role.
Arner P
Best Pract Res Clin Endocrinol Metab 2005 Dec;19(4):471-82. doi: 10.1016/j.beem.2005.07.004. PMID: 16311212

Therapy

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
The effects of a thermogenic supplement on metabolic and hemodynamic variables and subjective mood states.
Prather JM, Florez CM, Vargas A, Soto B, Harrison A, Willoughby D, Tinsley G, Taylor L
J Int Soc Sports Nutr 2023 Dec;20(1):2185538. doi: 10.1080/15502783.2023.2185538. PMID: 36862833Free PMC Article
Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2.
Rosenson RS, Stafforini DM
J Lipid Res 2012 Sep;53(9):1767-82. Epub 2012 Jun 4 doi: 10.1194/jlr.R024190. PMID: 22665167Free PMC Article
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MKC, Kunz I, Schrauwen-Hinderling VB, Blaak E, Auwerx J, Schrauwen P
Cell Metab 2011 Nov 2;14(5):612-22. doi: 10.1016/j.cmet.2011.10.002. PMID: 22055504Free PMC Article
Caffeine ingestion decreases glucose disposal during a hyperinsulinemic-euglycemic clamp in sedentary humans.
Greer F, Hudson R, Ross R, Graham T
Diabetes 2001 Oct;50(10):2349-54. doi: 10.2337/diabetes.50.10.2349. PMID: 11574419

Prognosis

Hepatic Steatosis Can Be Partly Generated by the Gut Microbiota-Mitochondria Axis via 2-Oleoyl Glycerol and Reversed by a Combination of Soy Protein, Chia Oil, Curcumin and Nopal.
Sánchez-Tapia M, Tobón-Cornejo S, Noriega LG, Vázquez-Manjarrez N, Coutiño-Hernández D, Granados-Portillo O, Román-Calleja BM, Ruíz-Margáin A, Macías-Rodríguez RU, Tovar AR, Torres N
Nutrients 2024 Aug 6;16(16) doi: 10.3390/nu16162594. PMID: 39203731Free PMC Article
SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
Research progress of fibroblast growth factor 23 in acute kidney injury.
Zhang L, Qin W
Pediatr Nephrol 2023 Jul;38(7):2013-2022. Epub 2022 Nov 22 doi: 10.1007/s00467-022-05791-z. PMID: 36416954Free PMC Article
Adipose-Derived Fatty Acid-Binding Proteins Plasma Concentrations Are Increased in Breast Cancer Patients.
Guaita-Esteruelas S, Saavedra-García P, Bosquet A, Borràs J, Girona J, Amiliano K, Rodríguez-Balada M, Heras M, Masana L, Gumà J
Oncologist 2017 Nov;22(11):1309-1315. Epub 2017 Jul 12 doi: 10.1634/theoncologist.2016-0483. PMID: 28701570Free PMC Article
Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury.
Johnston AJ, Steiner LA, Coles JP, Chatfield DA, Fryer TD, Smielewski P, Hutchinson PJ, O'Connell MT, Al-Rawi PG, Aigbirihio FI, Clark JC, Pickard JD, Gupta AK, Menon DK
Crit Care Med 2005 Jan;33(1):189-95; discussion 255-7. doi: 10.1097/01.ccm.0000149837.09225.bd. PMID: 15644668

Clinical prediction guides

SGLT1 and SGLT2 inhibition, circulating metabolites, and cerebral small vessel disease: a mediation Mendelian Randomization study.
Lv Y, Cheng X, Dong Q
Cardiovasc Diabetol 2024 May 7;23(1):157. doi: 10.1186/s12933-024-02255-6. PMID: 38715111Free PMC Article
The effects of a thermogenic supplement on metabolic and hemodynamic variables and subjective mood states.
Prather JM, Florez CM, Vargas A, Soto B, Harrison A, Willoughby D, Tinsley G, Taylor L
J Int Soc Sports Nutr 2023 Dec;20(1):2185538. doi: 10.1080/15502783.2023.2185538. PMID: 36862833Free PMC Article
Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists.
Depommier C, Vitale RM, Iannotti FA, Silvestri C, Flamand N, Druart C, Everard A, Pelicaen R, Maiter D, Thissen JP, Loumaye A, Hermans MP, Delzenne NM, de Vos WM, Di Marzo V, Cani PD
Cells 2021 Jan 19;10(1) doi: 10.3390/cells10010185. PMID: 33477821Free PMC Article
Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2.
Rosenson RS, Stafforini DM
J Lipid Res 2012 Sep;53(9):1767-82. Epub 2012 Jun 4 doi: 10.1194/jlr.R024190. PMID: 22665167Free PMC Article
Metabolic abnormalities in impaired glucose tolerance.
Gerich JE
Metabolism 1997 Dec;46(12 Suppl 1):40-3. doi: 10.1016/s0026-0495(97)90316-4. PMID: 9439558

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