U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Erythroleukemia

MedGen UID:
1614281
•Concept ID:
C4520840
•
Neoplastic Process
Synonyms: erythroleukemia; Erythroleukemia (Erythroid/Myeloid); Erythroleukemia, Erythroid/Myeloid
 
Monarch Initiative: MONDO:0859598

Definition

Acute erythroid leukemia characterised by the presence of at least 50% erythroid precursors and at least 20% myeloblasts in the bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythroleukemia

Professional guidelines

PubMed

The clinical outcomes of reclassified erythroleukemia (erythroid/myeloid) as myelodysplastic syndrome (MDS) per 2017 WHO guideline compared to MDS.
Alkharabsheh O, Al-Kali A, Saadeh S, He R, Viswanatha D, Greipp P, Reichard K, Shah M, Gangat N, Patnaik M, Hogan W, Litzow M, Alkhateeb H, Nguyen PL
Am J Hematol 2018 Nov;93(11):E355-E357. Epub 2018 Oct 2 doi: 10.1002/ajh.25239. PMID: 30074268
Erythroleukemia-historical perspectives and recent advances in diagnosis and management.
Boddu P, Benton CB, Wang W, Borthakur G, Khoury JD, Pemmaraju N
Blood Rev 2018 Mar;32(2):96-105. Epub 2017 Sep 18 doi: 10.1016/j.blre.2017.09.002. PMID: 28965757Free PMC Article
Review: erythroleukemia: clinical course and management.
Masood A, Holkova B, Chanan-Khan A
Clin Adv Hematol Oncol 2010 Apr;8(4):288-90. PMID: 20505652

Recent clinical studies

Etiology

Erythroleukemia: an Update.
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.
Izumikawa K, Ishikawa H, Simpson RJ, Takahashi N
RNA Biol 2018;15(7):849-855. Epub 2018 May 11 doi: 10.1080/15476286.2018.1465795. PMID: 29683372Free PMC Article
Revisiting erythroleukemia.
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Dysplasia has A differential diagnosis: distinguishing genuine myelodysplastic syndromes (MDS) from mimics, imitators, copycats and impostors.
Steensma DP
Curr Hematol Malig Rep 2012 Dec;7(4):310-20. doi: 10.1007/s11899-012-0140-3. PMID: 23015360
Double minutes in acute myeloid leukemia.
Li YS
Int J Cancer 1983 Oct 15;32(4):455-9. doi: 10.1002/ijc.2910320411. PMID: 6352519

Diagnosis

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.
Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Erythroleukemia: an Update.
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Pure erythroid leukemia.
Wang W, Wang SA, Medeiros LJ, Khoury JD
Am J Hematol 2017 Mar;92(3):292-296. Epub 2017 Feb 3 doi: 10.1002/ajh.24626. PMID: 28006859
Revisiting erythroleukemia.
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Reclassifying myelodysplastic syndromes: what's where in the new WHO and why.
Arber DA, Hasserjian RP
Hematology Am Soc Hematol Educ Program 2015;2015:294-8. doi: 10.1182/asheducation-2015.1.294. PMID: 26637736

Therapy

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.
Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Acute erythroleukemia, M6b.
Mazzella FM, Schumacher HR
Arch Pathol Lab Med 2000 Feb;124(2):330-1. doi: 10.5858/2000-124-0330-AEM. PMID: 10656753
Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma.
Nakagawa H, Tanaka S, Takashima T, Shizumi Y, Nishigaki H, Horiike S, Taniwaki M, Misawa S, Kashima K, Hironaka T
Int J Hematol 1991 Jun;54(3):213-7. PMID: 1660736
Acute myeloid leukemia and other myelopathic disorders following treatment with alkylating agents.
Bennett JM, Moloney WC, Greene MH, Boice JD Jr
Hematol Pathol 1987;1(2):99-104. PMID: 3504435
The antitumor effects of interferon.
Gresser I
Med Oncol Tumor Pharmacother 1986;3(3-4):223-30. doi: 10.1007/BF02934998. PMID: 2433551

Prognosis

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia.
Kuusanmäki H, Dufva O, Vähä-Koskela M, Leppä AM, Huuhtanen J, Vänttinen I, Nygren P, Klievink J, Bouhlal J, Pölönen P, Zhang Q, Adnan-Awad S, Mancebo-Pérez C, Saad J, Miettinen J, Javarappa KK, Aakko S, Ruokoranta T, Eldfors S, Heinäniemi M, Theilgaard-Mönch K, Wartiovaara-Kautto U, Keränen M, Porkka K, Konopleva M, Wennerberg K, Kontro M, Heckman CA, Mustjoki S
Blood 2023 Mar 30;141(13):1610-1625. doi: 10.1182/blood.2021011094. PMID: 36508699Free PMC Article
Erythroleukemia: an Update.
Weinberg OK, Arber DA
Curr Oncol Rep 2021 Apr 20;23(6):69. doi: 10.1007/s11912-021-01060-8. PMID: 33876292
Revisiting erythroleukemia.
Arber DA
Curr Opin Hematol 2017 Mar;24(2):146-151. doi: 10.1097/MOH.0000000000000314. PMID: 27875373
Reclassifying myelodysplastic syndromes: what's where in the new WHO and why.
Arber DA, Hasserjian RP
Hematology Am Soc Hematol Educ Program 2015;2015:294-8. doi: 10.1182/asheducation-2015.1.294. PMID: 26637736
Acute erythroid leukemia.
Zuo Z, Polski JM, Kasyan A, Medeiros LJ
Arch Pathol Lab Med 2010 Sep;134(9):1261-70. doi: 10.5858/2009-0350-RA.1. PMID: 20807044

Clinical prediction guides

Confirming the recessive inheritance of PERP-related erythrokeratoderma.
Patel N, Alkeraye S, Alobeid E, Alshidi T, Helaby R, Abdulwahab F, Shamseldin HE, Alkuraya FS
Clin Genet 2020 Apr;97(4):661-665. Epub 2020 Jan 12 doi: 10.1111/cge.13699. PMID: 31898316
Cloning and characterization of the human BAZF gene, a homologue of the BCL6 oncogene.
Sakashita C, Fukuda T, Okabe S, Kobayashi H, Hirosawa S, Tokuhisa T, Miyasaka N, Miura O, Miki T
Biochem Biophys Res Commun 2002 Mar 1;291(3):567-73. doi: 10.1006/bbrc.2002.6481. PMID: 11855826
The proteoglycan perlecan is expressed in the erythroleukemia cell line K562 and is upregulated by sodium butyrate and phorbol ester.
Grässel S, Cohen IR, Murdoch AD, Eichstetter I, Iozzo RV
Mol Cell Biochem 1995 Apr 12;145(1):61-8. doi: 10.1007/BF00925714. PMID: 7544867
The laser microbeam trap as an optical tool for living cells.
Leitz G, Weber G, Seeger S, Greulich KO
Physiol Chem Phys Med NMR 1994;26(1):69-88. PMID: 7938223
Acute erythroleukemia with t(3;5) accompanied by hepatocellular carcinoma.
Nakagawa H, Tanaka S, Takashima T, Shizumi Y, Nishigaki H, Horiike S, Taniwaki M, Misawa S, Kashima K, Hironaka T
Int J Hematol 1991 Jun;54(3):213-7. PMID: 1660736

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...