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Breast giant fibroadenoma

MedGen UID:
138039
•Concept ID:
C0346157
•
Neoplastic Process
Synonym: Giant adenofibroma of the breast
SNOMED CT: Giant fibroadenoma of breast (254846003); Serocystic disease of Brodie (254846003)
 
Monarch Initiative: MONDO:0004150

Definition

A breast fibroadenoma characterized by a very large size. This term has also been used as a synonym for juvenile fibroadenoma by some authors. The latter is characterized by epithelial hyperplasia and an increased stromal cellularity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast giant fibroadenoma

Professional guidelines

PubMed

Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy.
Gatta G, Iaselli F, Parlato V, Di Grezia G, Grassi R, Rotondo A
Radiol Med 2011 Sep;116(6):905-18. Epub 2011 Apr 19 doi: 10.1007/s11547-011-0672-y. PMID: 21509559
Diagnosis and treatment of symptomatic breast masses in the pediatric population.
West KW, Rescorla FJ, Scherer LR 3rd, Grosfeld JL
J Pediatr Surg 1995 Feb;30(2):182-6; discussion 186-7. doi: 10.1016/0022-3468(95)90557-x. PMID: 7738735
Practical aspects in the diagnosis and management of cystosarcoma phyllodes.
Hart J, Layfield LJ, Trumbull WE, Brayton D, Barker WF, Giuliano AE
Arch Surg 1988 Sep;123(9):1079-83. doi: 10.1001/archsurg.1988.01400330055008. PMID: 2843145

Recent clinical studies

Etiology

Breast diseases in adolescents.
Duflos C, Plu-Bureau G, Thibaud E, Kuttenn F
Endocr Dev 2012;22:208-221. Epub 2012 Jul 25 doi: 10.1159/000326690. PMID: 22846531
Fibroadenomas in adolescence.
Jayasinghe Y, Simmons PS
Curr Opin Obstet Gynecol 2009 Oct;21(5):402-6. doi: 10.1097/GCO.0b013e32832fa06b. PMID: 19606032
Breast disorders in children and adolescents.
Greydanus DE, Matytsina L, Gains M
Prim Care 2006 Jun;33(2):455-502. doi: 10.1016/j.pop.2006.02.002. PMID: 16713771
Fibrous histiocytoma of the breast.
Meshikhes AW, Jan GM, Al-Jaroof AH
Saudi Med J 2005 Feb;26(2):326-9. PMID: 15770318
Breast masses in childhood and adolescence. A presentation of 17 cases and a review of the literature.
Boothroyd A, Carty H
Pediatr Radiol 1994;24(2):81-4. doi: 10.1007/BF02020157. PMID: 8078727

Diagnosis

Atypical presentation of giant fibroadenoma of the breast.
Burud IAS, Azmi N
Pan Afr Med J 2021;39:168. Epub 2021 Jul 5 doi: 10.11604/pamj.2021.39.168.26975. PMID: 34539964Free PMC Article
Multinucleated Stromal Giant Cells in a Benign Fibroadenoma: Do Not Make a Mountain Out of a Molehill!
Schoelinck J, Galant C, Berlière M, Van Bockstal MR
Int J Surg Pathol 2021 Apr;29(2):182-183. Epub 2020 Mar 19 doi: 10.1177/1066896920914077. PMID: 32192397
Giant phyllodes tumor of the breast.
Pascarella S, Maher Z, Goldbach A, Hava S, Choksi R, Schneider C, Wagner J, Reilly K
Breast J 2020 Mar;26(3):550-552. Epub 2019 Sep 5 doi: 10.1111/tbj.13564. PMID: 31486153
Giant fibroadenoma.
Zacharia TT, Lakhar B, Ittoop A, Menachery J
Breast J 2003 Jan-Feb;9(1):53. doi: 10.1046/j.1524-4741.2003.09109.x. PMID: 12558674
Multiple, giant fibroadenoma.
Musio F, Mozingo D, Otchy DP
Am Surg 1991 Jul;57(7):438-41. PMID: 1647714

Therapy

Surgical management of giant juvenile fibroadenoma with skin reducing tumor resection and immediate breast reconstruction: A single-center experience.
Du F, Dong R, Zeng A, Liu Z, Yu N, Wang X, Zhu L
J Surg Oncol 2020 Mar;121(3):441-446. Epub 2020 Jan 6 doi: 10.1002/jso.25828. PMID: 31907948
A Unique Four-Point Approach for Removal of Giant Breast Fibroadenoma With Marked Asymmetry: A Modified Round Block Technique.
Cui H, Liu J, Guo J, Hu S, Xiang A, Ma S
J Invest Surg 2020 Sep;33(8):709-714. Epub 2019 May 9 doi: 10.1080/08941939.2019.1568647. PMID: 31070071
Breast fibroadenomas in renal transplant recipients.
Alkhunaizi AM, Ismail A, Yousif BM
Transplant Proc 2004 Jul-Aug;36(6):1839-40. doi: 10.1016/j.transproceed.2004.07.013. PMID: 15350492
Multiple bilateral giant juvenile fibroadenomas of breast.
Baxi M, Agarwal A, Mishra A, Agarwal G, Mishra SK
Eur J Surg 2000 Oct;166(10):828-30. doi: 10.1080/110241500447515. PMID: 11071174
Breast imaging case of the day. Multiple giant fibroadenomas associated with cyclosporin A therapy.
Cyrlak D, Pahl M, Carpenter SE
Radiographics 1999 Mar-Apr;19(2):549-51. doi: 10.1148/radiographics.19.2.g99mr24549. PMID: 10194798

Prognosis

Gene expression profiling of giant fibroadenomas of the breast.
Yin Lee JP, Thomas AJ, Lum SK, Shamsudin NH, Hii LW, Mai CW, Wong SF, Leong CO
Surg Oncol 2021 Jun;37:101536. Epub 2021 Mar 2 doi: 10.1016/j.suronc.2021.101536. PMID: 33677364
Surgery for giant tumours of the breast: a 15 year review.
Daya M, Balakrishnan T
S Afr J Surg 2018 Sep;56(3):9-15. PMID: 30264936
Treatment of unilateral giant fibroadenoma by breast reduction skin incision: the inverted "T" technique.
Achebe JU, Njeze GE, Okwesili OR
Niger J Clin Pract 2014 Jan-Feb;17(1):43-6. doi: 10.4103/1119-3077.122835. PMID: 24326806
Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy.
Gatta G, Iaselli F, Parlato V, Di Grezia G, Grassi R, Rotondo A
Radiol Med 2011 Sep;116(6):905-18. Epub 2011 Apr 19 doi: 10.1007/s11547-011-0672-y. PMID: 21509559
From the archives of the AFIP: breast masses in children and adolescents: radiologic-pathologic correlation.
Chung EM, Cube R, Hall GJ, González C, Stocker JT, Glassman LM
Radiographics 2009 May-Jun;29(3):907-31. doi: 10.1148/rg.293095010. PMID: 19448124

Clinical prediction guides

Giant juvenile fibroadenomas with and without prominent pseudoangiomatous stromal hyperplasia (PASH)-like change: clinicopathological and molecular characteristics.
Jorns JM, Farooq A, Puzyrenko A, Jarzembowski J, Thike AA, Nasir NDM, Ng CCY, Liu W, Lee JY, Lim AH, Guan P, Teh BT, Tan PH
Histopathology 2023 Sep;83(3):357-365. Epub 2023 May 4 doi: 10.1111/his.14935. PMID: 37140543
Gene expression profiling of giant fibroadenomas of the breast.
Yin Lee JP, Thomas AJ, Lum SK, Shamsudin NH, Hii LW, Mai CW, Wong SF, Leong CO
Surg Oncol 2021 Jun;37:101536. Epub 2021 Mar 2 doi: 10.1016/j.suronc.2021.101536. PMID: 33677364
Differential diagnosis between fibroadenoma, giant fibroadenoma and phyllodes tumour: sonographic features and core needle biopsy.
Gatta G, Iaselli F, Parlato V, Di Grezia G, Grassi R, Rotondo A
Radiol Med 2011 Sep;116(6):905-18. Epub 2011 Apr 19 doi: 10.1007/s11547-011-0672-y. PMID: 21509559
Histologic and cytogenetic observations on a case of giant fibroadenoma.
Olinici CD, Simu G
Neoplasma 1970;17(6):663-5. PMID: 4323588
Giant intracanalicular fibroadenoma. With report of five cases.
SMITH C Jr, PARSONS RJ, BOGART WM
Calif Med 1951 Aug;75(2):101-4. PMID: 14848732Free PMC Article

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