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Acquired factor VIII deficiency disease

MedGen UID:
124426
•Concept ID:
C0272325
•
Disease or Syndrome
Synonyms: Factor 8 deficiency, acquired; Factor VIII deficiency, acquired
SNOMED CT: Acquired factor VIII deficiency (14230004); Acquired factor VIII deficiency disease (14230004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0035735
Orphanet: ORPHA599480

Definition

An acquired coagulation disorder characterized by the partial or complete absence of factor VIII activity in the blood. [from NCI]

Professional guidelines

PubMed

Treatment guidelines for acquired hemophilia A.
Windyga J, Baran B, Odnoczko E, Buczma A, Drews K, Laudanski P, Pietrzak B, Sieroszewski P
Ginekol Pol 2019;90(6):353-364. doi: 10.5603/GP.2019.0063. PMID: 31276188
Acquired hemophilia A: Updated review of evidence and treatment guidance.
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963

Recent clinical studies

Etiology

Acquired hemophilia.
García-Chávez J, Majluf-Cruz A
Gac Med Mex 2020;156(1):67-77. doi: 10.24875/GMM.19005469. PMID: 32026881
Acquired hemophilia A: Updated review of evidence and treatment guidance.
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674
Newborn haemostasis.
Montgomery RR, Marlar RA, Gill JC
Clin Haematol 1985 Jun;14(2):443-60. PMID: 3899442
AIDS: acquired immunodeficiency syndrome.
Gilmore NJ, Beaulieu R, Steben M, Laverdière M
Can Med Assoc J 1983 Jun 1;128(11):1281-4. PMID: 6342737Free PMC Article
Surgical hemostasis.
Owen CA Jr, Bowie EJ
J Neurosurg 1979 Aug;51(2):137-42. doi: 10.3171/jns.1979.51.2.0137. PMID: 376788

Diagnosis

Acquired Hemophilia A.
Pai M
Hematol Oncol Clin North Am 2021 Dec;35(6):1131-1142. Epub 2021 Sep 15 doi: 10.1016/j.hoc.2021.07.007. PMID: 34535289
Acquired hemophilia.
García-Chávez J, Majluf-Cruz A
Gac Med Mex 2020;156(1):67-77. doi: 10.24875/GMM.19005469. PMID: 32026881
Acquired hemophilia A: Updated review of evidence and treatment guidance.
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article

Therapy

Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Acquired hemophilia.
García-Chávez J, Majluf-Cruz A
Gac Med Mex 2020;156(1):67-77. doi: 10.24875/GMM.19005469. PMID: 32026881
Treatment guidelines for acquired hemophilia A.
Windyga J, Baran B, Odnoczko E, Buczma A, Drews K, Laudanski P, Pietrzak B, Sieroszewski P
Ginekol Pol 2019;90(6):353-364. doi: 10.5603/GP.2019.0063. PMID: 31276188
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963
Surgical hemostasis.
Owen CA Jr, Bowie EJ
J Neurosurg 1979 Aug;51(2):137-42. doi: 10.3171/jns.1979.51.2.0137. PMID: 376788

Prognosis

Acquired hemophilia.
García-Chávez J, Majluf-Cruz A
Gac Med Mex 2020;156(1):67-77. doi: 10.24875/GMM.19005469. PMID: 32026881
Acquired hemophilia A: Updated review of evidence and treatment guidance.
Kruse-Jarres R, Kempton CL, Baudo F, Collins PW, Knoebl P, Leissinger CA, Tiede A, Kessler CM
Am J Hematol 2017 Jul;92(7):695-705. Epub 2017 Jun 5 doi: 10.1002/ajh.24777. PMID: 28470674
Acquired haemophilia: Epidemiology, clinical presentation, diagnosis and treatment.
Mingot-Castellano ME, Núñez R, Rodríguez-Martorell FJ
Med Clin (Barc) 2017 Apr 7;148(7):314-322. Epub 2017 Jan 22 doi: 10.1016/j.medcli.2016.11.030. PMID: 28118963
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Surgical hemostasis.
Owen CA Jr, Bowie EJ
J Neurosurg 1979 Aug;51(2):137-42. doi: 10.3171/jns.1979.51.2.0137. PMID: 376788

Clinical prediction guides

Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2022 May;28 Suppl 4:68-76. doi: 10.1111/hae.14548. PMID: 35521729
Acquired bleeding disorders.
Tiede A, Zieger B, Lisman T
Haemophilia 2021 Feb;27 Suppl 3:5-13. Epub 2020 Jun 1 doi: 10.1111/hae.14033. PMID: 32476241
Fibrinolysis and the control of blood coagulation.
Chapin JC, Hajjar KA
Blood Rev 2015 Jan;29(1):17-24. Epub 2014 Sep 16 doi: 10.1016/j.blre.2014.09.003. PMID: 25294122Free PMC Article
Replacing bad (F)actors: hemophilia.
Doering CB, Spencer HT
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):461-7. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.461. PMID: 25696895
Protein C.
Esmon CT
Prog Hemost Thromb 1984;7:25-54. PMID: 6099583

Recent systematic reviews

Rituximab for eradicating inhibitors in people with acquired haemophilia A.
Remmington T, Smith S
Cochrane Database Syst Rev 2021 Aug 23;8(8):CD011907. doi: 10.1002/14651858.CD011907.pub3. PMID: 34423414Free PMC Article
Mortality in congenital hemophilia A - a systematic literature review.
Hay CRM, Nissen F, Pipe SW
J Thromb Haemost 2021 Jan;19 Suppl 1(Suppl 1):6-20. doi: 10.1111/jth.15189. PMID: 33331043Free PMC Article
Rituximab for eradicating inhibitors in people with acquired haemophilia A.
Zeng Y, Zhou R, Duan X, Long D
Cochrane Database Syst Rev 2016 Jul 8;7(7):CD011907. doi: 10.1002/14651858.CD011907.pub2. PMID: 27387850Free PMC Article
The prognosis and treatment of acquired hemophilia: a systematic review and meta-analysis.
Bitting RL, Bent S, Li Y, Kohlwes J
Blood Coagul Fibrinolysis 2009 Oct;20(7):517-23. doi: 10.1097/MBC.0b013e32832ca388. PMID: 19644360
Acquired factor VIII inhibitors in oncohematology: a systematic review.
Franchini M, Targher G, Manzato F, Lippi G
Crit Rev Oncol Hematol 2008 Jun;66(3):194-9. Epub 2008 Feb 19 doi: 10.1016/j.critrevonc.2007.12.004. PMID: 18243727

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