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Bone osteosarcoma

MedGen UID:
108437
•Concept ID:
C0585442
•
Neoplastic Process
Synonym: Osteosarcoma, somatic
SNOMED CT: Osteosarcoma of bone (307576001)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Genes (locations): CHEK2 (22q12.1); RB1 (13q14.2); TP53 (17p13.1)
 
Monarch Initiative: MONDO:0002629
OMIM®: 259500
Orphanet: ORPHA668

Definition

Osteosarcoma is a primary malignant tumour of the skeleton characterised by the direct formation of immature bone or osteoid tissue by the tumour cells. [from ORDO]

Clinical features

From HPO
Osteosarcoma
MedGen UID:
10501
•Concept ID:
C0029463
•
Neoplastic Process
A malignant bone tumor that usually develops during adolescence and usually affects the long bones including the tibia, femur, and humerus. The typical symptoms of osteosarcoma comprise bone pain, fracture, limitation of motion, and tenderness or swelling at the site of the tumor.
See: Feature record | Search on this feature
Retinoblastoma
MedGen UID:
20552
•Concept ID:
C0035335
•
Neoplastic Process
Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma may be unifocal or multifocal. About 60% of affected individuals have unilateral retinoblastoma with a mean age of diagnosis of 24 months; about 40% have bilateral retinoblastoma with a mean age of diagnosis of 15 months. Heritable retinoblastoma is associated with susceptibility for retinoblastoma as well as non-ocular tumors.
See: Feature record | Search on this feature

Professional guidelines

PubMed

GPR120 agonists for the treatment of diabetes: a patent review (2014 present).
Zhang X, Macielag MJ
Expert Opin Ther Pat 2020 Oct;30(10):729-742. Epub 2020 Aug 30 doi: 10.1080/13543776.2020.1811852. PMID: 32799609

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

Recent clinical studies

Etiology

A Retrospective Comparative Analysis of Outcomes and Prognostic Factors in Adult and Pediatric Patients with Osteosarcoma.
Testa S, Hu BD, Saadeh NL, Pribnow A, Spunt SL, Charville GW, Bui NQ, Ganjoo KN
Curr Oncol 2021 Dec 12;28(6):5304-5317. doi: 10.3390/curroncol28060443. PMID: 34940082Free PMC Article
MsrB1 Promotes Proliferation and Invasion of Colorectal Cancer Cells via GSK-3β/β-catenin Signaling Axis.
Chen XY, Yang SY, Ruan XJ, Ding HY, Wang NX, Liu F, Li JC, Li Y
Cell Transplant 2021 Jan-Dec;30:9636897211053203. doi: 10.1177/09636897211053203. PMID: 34719306Free PMC Article
Retrospective investigation of hereditary syndromes in patients with medulloblastoma in a single institution.
Wang Y, Wu J, Li W, Li J, Liu R, Yang B, Li C, Jiang T
Childs Nerv Syst 2021 Feb;37(2):411-417. Epub 2020 Sep 15 doi: 10.1007/s00381-020-04885-z. PMID: 32930885
Functional outcome following excision of tumours of the distal radius and reconstruction by autologous non-vascularized osteoarticular fibula grafting.
Maruthainar N, Zambakidis C, Harper G, Calder D, Cannon SR, Briggs TW
J Hand Surg Br 2002 Apr;27(2):171-4. doi: 10.1054/jhsb.2001.0707. PMID: 12027495
Diaphyseal osteosarcoma.
Haworth JM, Watt I, Park WM, Roylance J
Br J Radiol 1981 Nov;54(647):932-8. doi: 10.1259/0007-1285-54-647-932. PMID: 6946854

Diagnosis

An Unusual Histopathological Presentation of Mandibular Osteosarcoma.
Alramadhan SA, Vyas R, Cohen DM, Bhattacharyya I, Islam MN, Reith JD
Head Neck Pathol 2024 Nov 19;18(1):121. doi: 10.1007/s12105-024-01724-4. PMID: 39560895Free PMC Article
Extraskeletal osteosarcomas: current update.
Kattepur AK, Gulia A, Jones RL, Rastogi S
Future Oncol 2021 Mar;17(7):825-835. Epub 2021 Feb 3 doi: 10.2217/fon-2020-0802. PMID: 33533642
Primary Cutaneous Osteosarcoma.
Fiegen AP, Tjarks BJ, Jassim AD
S D Med 2018 Apr;71(4):164-166. PMID: 29996033
Epiphyseal involvement in osteosarcoma.
Norton KI, Hermann G, Abdelwahab IF, Klein MJ, Granowetter LF, Rabinowitz JG
Radiology 1991 Sep;180(3):813-6. doi: 10.1148/radiology.180.3.1871299. PMID: 1871299
Diaphyseal osteosarcoma.
Haworth JM, Watt I, Park WM, Roylance J
Br J Radiol 1981 Nov;54(647):932-8. doi: 10.1259/0007-1285-54-647-932. PMID: 6946854

Therapy

A Retrospective Comparative Analysis of Outcomes and Prognostic Factors in Adult and Pediatric Patients with Osteosarcoma.
Testa S, Hu BD, Saadeh NL, Pribnow A, Spunt SL, Charville GW, Bui NQ, Ganjoo KN
Curr Oncol 2021 Dec 12;28(6):5304-5317. doi: 10.3390/curroncol28060443. PMID: 34940082Free PMC Article
Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner.
Lellupitiyage Don SS, Robertson KL, Lin HH, Labriola C, Harrington ME, Taylor SR, Farkas ME
PLoS One 2020;15(7):e0236315. Epub 2020 Jul 24 doi: 10.1371/journal.pone.0236315. PMID: 32706791Free PMC Article
Preparation of adriamycin gelatin microsphere-loaded decellularized periosteum that is cytotoxic to human osteosarcoma cells.
Chen C, Dong J, Chen H, Wang X, Mei J, Wang L, Xian CJ
J Cell Physiol 2019 Jul;234(7):10771-10781. Epub 2018 Nov 27 doi: 10.1002/jcp.27753. PMID: 30480804
Primary bone osteosarcoma in the pediatric age: state of the art.
Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G
Cancer Treat Rev 2006 Oct;32(6):423-36. Epub 2006 Jul 24 doi: 10.1016/j.ctrv.2006.05.005. PMID: 16860938
Malignancy from radium.
Loutit JF
Br J Cancer 1970 Jun;24(2):195-207. doi: 10.1038/bjc.1970.23. PMID: 5271269Free PMC Article

Prognosis

A Retrospective Comparative Analysis of Outcomes and Prognostic Factors in Adult and Pediatric Patients with Osteosarcoma.
Testa S, Hu BD, Saadeh NL, Pribnow A, Spunt SL, Charville GW, Bui NQ, Ganjoo KN
Curr Oncol 2021 Dec 12;28(6):5304-5317. doi: 10.3390/curroncol28060443. PMID: 34940082Free PMC Article
GEM-Based Metabolic Profiling for Human Bone Osteosarcoma under Different Glucose and Glutamine Availability.
Weglarz-Tomczak E, Rijlaarsdam DJ, Tomczak JM, Brul S
Int J Mol Sci 2021 Feb 2;22(3) doi: 10.3390/ijms22031470. PMID: 33540580Free PMC Article
Primary bone osteosarcoma in the pediatric age: state of the art.
Longhi A, Errani C, De Paolis M, Mercuri M, Bacci G
Cancer Treat Rev 2006 Oct;32(6):423-36. Epub 2006 Jul 24 doi: 10.1016/j.ctrv.2006.05.005. PMID: 16860938
Treatment of a second bone osteosarcoma. 3 cases and an unusual MRI finding.
Marcove RC, Heelan R, Lindeque B, Healey J, Rosen G
Acta Orthop Scand 1994 Aug;65(4):480-2. doi: 10.3109/17453679408995497. PMID: 7976302
Epiphyseal involvement in osteosarcoma.
Norton KI, Hermann G, Abdelwahab IF, Klein MJ, Granowetter LF, Rabinowitz JG
Radiology 1991 Sep;180(3):813-6. doi: 10.1148/radiology.180.3.1871299. PMID: 1871299

Clinical prediction guides

Zinc substituted hydroxyapatite/silk fiber/methylcellulose nanocomposite for bone tissue engineering applications.
Valarmathi N, Sumathi S
Int J Biol Macromol 2022 Aug 1;214:324-337. Epub 2022 Jun 9 doi: 10.1016/j.ijbiomac.2022.06.033. PMID: 35691428
A Retrospective Comparative Analysis of Outcomes and Prognostic Factors in Adult and Pediatric Patients with Osteosarcoma.
Testa S, Hu BD, Saadeh NL, Pribnow A, Spunt SL, Charville GW, Bui NQ, Ganjoo KN
Curr Oncol 2021 Dec 12;28(6):5304-5317. doi: 10.3390/curroncol28060443. PMID: 34940082Free PMC Article
GEM-Based Metabolic Profiling for Human Bone Osteosarcoma under Different Glucose and Glutamine Availability.
Weglarz-Tomczak E, Rijlaarsdam DJ, Tomczak JM, Brul S
Int J Mol Sci 2021 Feb 2;22(3) doi: 10.3390/ijms22031470. PMID: 33540580Free PMC Article
Jaw osteosarcoma models in mice: first description.
Bertin H, Guilho R, Brion R, Amiaud J, Battaglia S, Moreau A, Brouchet-Gomez A, Longis J, Piot B, Heymann D, Corre P, Rédini F
J Transl Med 2019 Feb 27;17(1):56. doi: 10.1186/s12967-019-1807-5. PMID: 30813941Free PMC Article
Epiphyseal involvement in osteosarcoma.
Norton KI, Hermann G, Abdelwahab IF, Klein MJ, Granowetter LF, Rabinowitz JG
Radiology 1991 Sep;180(3):813-6. doi: 10.1148/radiology.180.3.1871299. PMID: 1871299

Supplemental Content

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    Clinical resources

    Practice guidelines

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bone Cancer, 2024

    Reviews

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    • Gene
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    • GTR(Clinical)
      Clinical tests in GTR
    • OMIM
      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
    • PMC Articles
      Related information in PubMed Central Links
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