- Potent Anti-Diabetic Actions of a Novel Non-Agonist PPARγ Ligand that Blocks Cdk5-Mediated Phosphorylation
- Discovery and Development of Highly Potent Inhibitors of Mycobacterium tuberculosis Growth In Vitro
- Selective, reversible inhibitors of the AAA ATPase p97
- ML238: An Antimalarial Small Molecule of a Unique Structural Class
- B-cell Specific Inhibitors of NF-κB Activation
- Functional Agonists of the Apelin (APJ) Receptor
- A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV
- Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway
- Selective Efflux Inhibition of ATP-binding Cassette Sub-family G Member 2
- Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3
- Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway
- Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211
- Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2)
- Functional antagonists of the Apelin (APJ) receptor
- Modulators of Lipid Storage
- Scaffold Hopping Affords a Highly Selective in vitro and in vivo T-Type Calcium Inhibitor Probe Free From IP Issues
- Reversible and non-covalent benzimidazole-based in vivo lead for Chagas disease
- Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase
- Discovery of Inhibitors of Anti-Apoptotic Protein A1
- A small molecule activator of KCNQ2 and KCNQ4 channels
- Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2
- Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2)
- Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2
- Identification of Potent and Selective RORγ Antagonists
- Identification of Inhibitors of Trypanosoma brucei Hexokinases
- Novel Chemical Inhibitor of TRPC4 Channels
- 5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2
- Small Molecule Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1)
- Selective GPR35 Antagonists - Probe 3
- Screening for Selective Ligands for GPR55 - Antagonists
- Antagonist for the Kappa Opioid Receptor
- Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence
- Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells
- Screening for Selective Ligands for GPR55 - Agonists
- Discovery of a potent, selective and orally active in vivo mGlu4 positive allosteric modulator
- Optimization and Characterization of an Antagonist for G-Protein Coupled Receptor 7 (GPR7)
- Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2)
- Probe Development Efforts to Identify Novel Agonists of the Sphingosine 1-phosphate Receptor 4 (S1P4)
- Identification of Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry
- Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORα)
- Optimization and Characterization of an Inhibitor for Glutathione S-Tranferase Omega 1 (GSTO1)
- Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1)
- Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity
- Development of the First Highly Selective mAChR 5 (M5) Positive Allosteric Modulator (PAM)
- Optimization and Characterization of an Inhibitor for NADPH Oxidase 1 (NOX-1)
Publication Details
Copyright
Publisher
National Center for Biotechnology Information (US), Bethesda (MD)
NLM Citation
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Year 3 Reports.