- Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators
- Antagonists of IAP-family anti-apoptotic proteins - Probe 2
- Identification of activators for the M2 isoform of human pyruvate kinase Version 3
- Discovery and development of a second highly selective M1 Positive Allosteric Modulator (PAM)
- Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression
- An inhibitor of the Cdc2-like kinase 4 (Clk4)
- Inhibitors of Platelet Integrin αllbβ3
- Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 1
- Identification of a small molecule that selectively activates alpha-synuclein translational expression
- Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1
- Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3
- Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2
- Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1
- Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3
- Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection
- Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 2
- Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1
- Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor
- Toward Improved Therapy for Classic Galactosemia
- qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2
- Identification of a small molecule that selectively inhibits alpha-synuclein translational expression
- Potent and selective inhibitors of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD)
- High Throughput Screening Assays for NOD1 Inhibitors - Probe 2
- Selective GPR35 Antagonists - Probes 1 & 2
- A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus
- A Potent and Selective Inhibitor of Cdc42 GTPase
- Selective KOP Receptor Antagonists: Probe 1
- Selective KOP Receptor Agonists: Probe 1 & Probe 2
- Discovery and development of the a highly selective M1 Positive Allosteric Modulator (PAM)
- Probe Report for PME-1 Inhibitors
- Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 3
- Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2
- A potent and selective small molecule Kir2.1 inhibitor
- A small molecule inhibitor of Caspase 1
- Probe Development Efforts to Identify Novel Antagonists of the Sphingosine 1-phosphate Receptor 4 (S1P4)
- High Throughput Screening Assays for NOD1 Inhibitors - Probe 1
- Discovery of the first mAChR 5 (M5) selective ligand, an M5 Positive Allosteric Modulator (PAM)
- Discovery of a potent, selective and in vivo active mGluR4 positive allosteric modulator
- Selective Small Molecule Inhibitors of 12-Human Lipoxygenase (12-hLO)
- Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1
- Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR)
- Campaign to Identify Agonists of Transient Receptor Potential Channels 3 and 2 (TRPML3 & TRPML2)
- HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors
- Selective HePTP Inhibitors: Probe 2
- Selective HePTP Inhibitors: Probe 1
- Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry
- Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Inhibitors)
- Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Activators)
- Probe Report for RBBP9 Inhibitors - Probe 2
- Small-Molecule Inhibitors of Vaccinia-H1-Related Phosphatase VHR
- Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity
- Discovery of a small molecule inhibitor of ROMK and Kir7.1
- Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists
- Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM)
Publication Details
Copyright
Publisher
National Center for Biotechnology Information (US), Bethesda (MD)
NLM Citation
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Year 2 Reports.