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Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
- Discovery, SAR and Biological Evaluation of Aryl-thiazol-piperidines as SMN Modulators
- Antagonists of IAP-family anti-apoptotic proteins - Probe 2
- Identification of activators for the M2 isoform of human pyruvate kinase Version 3
- Discovery and development of a second highly selective M1 Positive Allosteric Modulator (PAM)
- Identification of compounds which inhibit cytotoxicity associated with mutant Huntingtin protein expression
- An inhibitor of the Cdc2-like kinase 4 (Clk4)
- Inhibitors of Platelet Integrin αllbβ3
- Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 1
- Identification of a small molecule that selectively activates alpha-synuclein translational expression
- Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1
- Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3
- Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2
- Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1
- Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3
- Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection
- Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 2
- Identification of Modulators of the N370S Mutant Form of Glucocerebrosidase as a Potential Therapy for Gaucher Disease - Chemotype 1
- Identification of Small Molecule Antagonists of the Neuropeptide-S Receptor
- Toward Improved Therapy for Classic Galactosemia
- qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2
- Identification of a small molecule that selectively inhibits alpha-synuclein translational expression
- Potent and selective inhibitors of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (HPGD)
- High Throughput Screening Assays for NOD1 Inhibitors - Probe 2
- Selective GPR35 Antagonists - Probes 1 & 2
- A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus
- A Potent and Selective Inhibitor of Cdc42 GTPase
- Selective KOP Receptor Antagonists: Probe 1
- Selective KOP Receptor Agonists: Probe 1 & Probe 2
- Discovery and development of the a highly selective M1 Positive Allosteric Modulator (PAM)
- Probe Report for PME-1 Inhibitors
- Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 3
- Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2
- A potent and selective small molecule Kir2.1 inhibitor
- A small molecule inhibitor of Caspase 1
- Probe Development Efforts to Identify Novel Antagonists of the Sphingosine 1-phosphate Receptor 4 (S1P4)
- High Throughput Screening Assays for NOD1 Inhibitors - Probe 1
- Discovery of the first mAChR 5 (M5) selective ligand, an M5 Positive Allosteric Modulator (PAM)
- Discovery of a potent, selective and in vivo active mGluR4 positive allosteric modulator
- Selective Small Molecule Inhibitors of 12-Human Lipoxygenase (12-hLO)
- Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1
- Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR)
- Campaign to Identify Agonists of Transient Receptor Potential Channels 3 and 2 (TRPML3 & TRPML2)
- HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors
- Selective HePTP Inhibitors: Probe 2
- Selective HePTP Inhibitors: Probe 1
- Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry
- Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Inhibitors)
- Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Activators)
- Probe Report for RBBP9 Inhibitors - Probe 2
- Small-Molecule Inhibitors of Vaccinia-H1-Related Phosphatase VHR
- Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity
- Discovery of a small molecule inhibitor of ROMK and Kir7.1
- Identification of Potent and Selective Thyroid Stimulating Hormone Receptor Agonists
- Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM)
- Year 2 Reports - Probe Reports from the NIH Molecular Libraries ProgramYear 2 Reports - Probe Reports from the NIH Molecular Libraries Program
- Optimization and Characterization of an Inhibitor for NADPH Oxidase 1 (NOX-1) - ...Optimization and Characterization of an Inhibitor for NADPH Oxidase 1 (NOX-1) - Probe Reports from the NIH Molecular Libraries Program
- Development of the First Highly Selective mAChR 5 (M5) Positive Allosteric Modul...Development of the First Highly Selective mAChR 5 (M5) Positive Allosteric Modulator (PAM) - Probe Reports from the NIH Molecular Libraries Program
- Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modu...Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator (PAM) Series with Greatly Improved Human Receptor Activity - Probe Reports from the NIH Molecular Libraries Program
- Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Me...Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1) - Probe Reports from the NIH Molecular Libraries Program
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