Breast cancer has become the most diagnosed cancer globally, surpassing lung and prostate cancers. In 2020, 2.3 million females were diagnosed with breast cancer worldwide. The incidence and related mortality from breast cancer continue to grow despite remarkable advances in our understanding of the biology of breast cancer and the availability of better therapeutic options. Therapies currently used to treat metastatic breast cancer extend the survival and quality of life of patients, but they are not curative. Therefore, a better understanding of the mechanisms involved in metastatic dissemination is of pivotal importance. This book provides a unique blend of carefully presented and structured information covering a broad array of relevant breast cancer-related issues. The first eight chapters cover breast cancer epidemiology, etiology, subtypes, current and emerging surgical innovations to treat and image breast cancer, a description of noninvasive lymphedema assessment methods to detect and track this important treatment complication, and the potential role of platelets and galectins in breast cancer metastasis. The last five chapters are devoted to the description of forward-looking albeit potential breast cancer treatment possibilities. In this regard, different chapters of the book describe novel research on the potential of ubiquitin-specific protease 18 (USP-18), ribosomal protein S6 kinase 1 (RPS6K1), the lysosomal system, nanoparticles, and proteolysis target chimeras as therapeutic agents for breast cancer. The range of clinical and translational research of breast cancer presented in this book will be of interest to healthcare professionals, clinicians, and basic scientists.
Dr. Harvey N. Mayrovitz did his PhD graduate work at the University of Pennsylvania and trained at Temple University School of Medicine and the Graduate Hospital in Philadelphia and at the Medical Faculty and Hospital in Rotterdam and Delft University in the Netherlands. In 1998, after serving as the Director of Cardiovascular Research at the Miami Heart Research Institute in Miami Beach Florida, he joined Nova Southeastern University in Ft. Lauderdale Florida where he is now a professor of physiology in the Dr. Kiran C. Patel College of Allopathic Medicine in the Department of Medical Education. His teaching areas include cardiovascular and pulmonary physiology directed toward medical and graduate health-science students. His current research areas include cardiopulmonary, lymphedema, and mostly noninvasive clinical and biophysical studies for diagnosis and therapy. He has authored over 150 scientific publications in these and related areas along with multiple book chapters. He continues his research activities and student mentoring with the most current research focused on developing ways to assess and better understand processes associated with lymphedema detection, progression, and its treatment. He is also actively investigating the potential of various forms of electromagnetic energy to influence blood flow and other physiological parameters.
Breast Cancer
ISBN: 978-0-6453320-3-2
DOI: https://doi.org/10.36255/exon-publications-breast-cancer
Edited by
Harvey N. Mayrovitz, PhD, Department of Medical Education, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, FL, USA
Published by
Exon Publications, Brisbane, Australia
Copyright© 2022 Exon Publications
Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). https://creativecommons.org/licenses/by-nc/4.0/. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.
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First Published in August 2022
Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). https://creativecommons.org/licenses/by-nc/4.0/. Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The book in its entirety is subject to copyright by the publisher. The reproduction, modification, replication and display of the book in its entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.