| Reference | Reason for exclusion |
|---|---|
| Athanasakis 201121 | This study was assessed as partially applicable with very serious limitations because although it is comparing treatment versus no treatment in a hypertensive population, the treatment effect is based on observational systolic BPs in a treated and untreated group being put into a risk calculator as above. |
| Ferket 201764 | This study was assessed as not applicable because the intervention that is being compared in different CV risk subgroups is a polypill that also includes a statin. |
| Kypridemos 2018105 | This study was assessed as not applicable because it is comparing different types of implementation of NHS health check, which can lead to identification of many conditions and not just hypertension, so it is not just about antihypertensive treatment. |
| Stevanovic 2014161 | This study was assessed as partially applicable with very serious limitations because although it is comparing treatment versus no treatment in a hypertensive population, it uses a different risk calculator to what would be used in the UK. It also uses BP reduction for treatment effect (rather than a relative risk reduction in events) and predicts events through the calculator which should ideally be used only for baseline risks. It also has different treatment steps to UK practice. |
From: Evidence review for initiating treatment
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