| 1. | exp Hypertension/ |
| 2. | hypertens*.ti,ab. |
| 3. | (elevat* adj2 blood adj pressur*).ti,ab. |
| 4. | (high adj blood adj pressur*).ti,ab. |
| 5. | (increase* adj2 blood pressur*).ti,ab. |
| 6. | ((systolic or diastolic or arterial) adj2 pressur*).ti,ab. |
| 7. | or/1–6 |
| 8. | letter.pt. or letter/ |
| 9. | note.pt. |
| 10. | editorial.pt. |
| 11. | case report/ or case study/ |
| 12. | (letter or comment*).ti. |
| 13. | or/8–12 |
| 14. | randomized controlled trial/ or random*.ti,ab. |
| 15. | 13 not 14 |
| 16. | animal/ not human/ |
| 17. | nonhuman/ |
| 18. | exp Animal Experiment/ |
| 19. | exp Experimental Animal/ |
| 20. | animal model/ |
| 21. | exp Rodent/ |
| 22. | (rat or rats or mouse or mice).ti. |
| 23. | or/15–22 |
| 24. | 7 not 23 |
| 25. | limit 24 to English language |
| 26. | health economics/ |
| 27. | exp economic evaluation/ |
| 28. | exp health care cost/ |
| 29. | exp fee/ |
| 30. | budget/ |
| 31. | funding/ |
| 32. | budget*.ti,ab. |
| 33. | cost*.ti. |
| 34. | (economic* or pharmaco?economic*).ti. |
| 35. | (price* or pricing*).ti,ab. |
| 36. | (cost* adj2 (effective* or utilit* or benefit* or minimi* or unit* or estimat* or variable*)).ab. |
| 37. | (financ* or fee or fees).ti,ab. |
| 38. | (value adj2 (money or monetary)).ti,ab. |
| 39. | or/26–38 |
| 40. | 25 and 39 |
From: Evidence review for initiating treatment
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