| 1. | exp Hypertension/ |
| 2. | hypertens*.ti,ab. |
| 3. | (elevat* adj2 blood adj pressur*).ti,ab. |
| 4. | (high adj blood adj pressur*).ti,ab. |
| 5. | (increase* adj2 blood pressur*).ti,ab. |
| 6. | ((systolic or diastolic or arterial) adj2 pressur*).ti,ab. |
| 7. | or/1–6 |
| 8. | exp pregnancy/ |
| 9. | exp Hypertension, Pregnancy-Induced/ not exp Hypertension/ |
| 10. | (pre eclampsia or pre-eclampsia or preeclampsia).ti,ab. |
| 11. | exp Hypertension, Portal/ not exp Hypertension/ |
| 12. | exp Hypertension, Pulmonary/ not exp Hypertension/ |
| 13. | exp Intracranial Hypertension/ not exp Hypertension/ |
| 14. | exp Ocular Hypertension/ not exp Hypertension/ |
| 15. | exp Diabetes Mellitus, Type 1/ not exp Diabetes Mellitus, Type 2/ |
| 16. | or/8–15 |
| 17. | 7 not 16 |
| 18. | letter/ |
| 19. | editorial/ |
| 20. | news/ |
| 21. | exp historical article/ |
| 22. | Anecdotes as Topic/ |
| 23. | comment/ |
| 24. | case report/ |
| 25. | (letter or comment*).ti. |
| 26. | or/18–25 |
| 27. | randomized controlled trial/ or random*.ti,ab. |
| 28. | 26 not 27 |
| 29. | animals/ not humans/ |
| 30. | exp Animals, Laboratory/ |
| 31. | exp Animal Experimentation/ |
| 32. | exp Models, Animal/ |
| 33. | exp Rodentia/ |
| 34. | (rat or rats or mouse or mice).ti. |
| 35. | or/28–34 |
| 36. | 17 not 35 |
| 37. | (exp child/ or exp pediatrics/ or exp infant/) not (exp adolescent/ or exp adult/ or exp middle age/ or exp aged/) |
| 38. | 36 not 37 |
| 39. | limit 38 to English language |
| 40. | exp antihypertensive agents/ |
| 41. | (anti-hypertens* or antihypertens* or anti hypertens*).ti,ab. |
| 42. | 40 or 41 |
| 43. | risk factors/ |
| 44. | risk assessment/ |
| 45. | ((initiat* or start* or commenc* or begin*) adj4 (treatment* or medicat*)).ti,ab. |
| 46. | (risk* adj2 (factor* or assess*)).ti,ab. |
| 47. | (threshold* or level*).ti,ab. |
| 48. | or/43–47 |
| 49. | 39 and 42 and 48 |
| 50. | randomized controlled trial.pt. |
| 51. | controlled clinical trial.pt. |
| 52. | randomi#ed.ti,ab. |
| 53. | placebo.ab. |
| 54. | randomly.ti,ab. |
| 55. | Clinical Trials as topic.sh. |
| 56. | trial.ti. |
| 57. | or/50–56 |
| 58. | Meta-Analysis/ |
| 59. | exp Meta-Analysis as Topic/ |
| 60. | (meta analy* or metanaly* or metaanaly* or meta regression).ti,ab. |
| 61. | ((systematic* or evidence*) adj3 (review* or overview*)).ti,ab. |
| 62. | (reference list* or bibliograph* or hand search* or manual search* or relevant journals).ab. |
| 63. | (search strategy or search criteria or systematic search or study selection or data extraction).ab. |
| 64. | (search* adj4 literature).ab. |
| 65. | (medline or pubmed or cochrane or embase or psychlit or psyclit or psychinfo or psycinfo or cinahl or science citation index or bids or cancerlit).ab. |
| 66. | cochrane.jw. |
| 67. | ((multiple treatment* or indirect or mixed) adj2 comparison*).ti,ab. |
| 68. | or/58–67 |
| 69. | Epidemiologic studies/ |
| 70. | Observational study/ |
| 71. | exp Cohort studies/ |
| 72. | (cohort adj (study or studies or analys* or data)).ti,ab. |
| 73. | ((follow up or observational or uncontrolled or non randomi#ed or epidemiologic*) adj (study or studies or data)).ti,ab. |
| 74. | ((longitudinal or retrospective or prospective or cross sectional) and (study or studies or review or analys* or cohort* or data)).ti,ab. |
| 75. | Controlled Before-After Studies/ |
| 76. | Historically Controlled Study/ |
| 77. | Interrupted Time Series Analysis/ |
| 78. | (before adj2 after adj2 (study or studies or data)).ti,ab. |
| 79. | or/69–78 |
| 80. | exp case control study/ |
| 81. | case control*.ti,ab. |
| 82. | or/80–81 |
| 83. | 79 or 82 |
| 84. | Cross-sectional studies/ |
| 85. | (cross sectional and (study or studies or review or analys* or cohort* or data)).ti,ab. |
| 86. | or/84–85 |
| 87. | 79 or 86 |
| 88. | 79 or 82 or 86 |
| 89. | 49 and (57 or 68 or 88) |
From: Evidence review for initiating treatment
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.