Table 9Clinical evidence profile: Surgery versus no surgery for PHPT in pregnant women

Quality assessmentNo of patientsEffectQualityImportance
No of studiesDesignRisk of biasInconsistencyIndirectnessImprecisionOther considerationsSurgeryNo surgeryRelative (95% CI)Absolute
Stillbirth (before diagnosis) (follow-up from years 1977 to 2010; assessed with: number of cases)
1observational studiesSeriousano serious inconsistencyno serious indirectnessSeriousbNone

12/576

(2.1%)

0.2%RR 7.52 (0.96 to 59.11)13 more per 1000 (from 0 fewer to 116 more)

⊕◯◯◯

VERY LOW

IMPORTANT
a

Downgraded by 1 increment if the majority of the evidence was at high risk of bias, and downgraded by 2 increments if the majority of the evidence was at very high risk of bias (outcome reporting bias)

b

Downgraded by 1 increment if the confidence interval crossed one MID or by 2 increments if the confidence interval crossed both MIDs

From: Evidence review for pregnancy

Cover of Evidence review for pregnancy
Evidence review for pregnancy: Hyperparathyroidism (primary): diagnosis, assessment and initial management: Evidence review J.
NICE Guideline, No. 132.
National Guideline Centre (UK).
Copyright © NICE 2019.

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