Examples of GPI-Anchored Proteins

Michael AJ Ferguson; Gerald W Hart; Taroh Kinoshita

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Online Appendix 12AExamples of GPI-Anchored Proteins

Ferguson MAJ, Hart GW, Kinoshita T.

Publication Details

Table 1

Publication Details

Author Information and Affiliations

Authors

Michael AJ Ferguson, Gerald W Hart, and Taroh Kinoshita.

Publication History

Published online: September 5, 2017.

Copyright

PDF files are not available for download.

Publisher

Cold Spring Harbor Laboratory Press, Cold Spring Harbor (NY)

NLM Citation

Ferguson MAJ, Hart GW, Kinoshita T. Examples of GPI-Anchored Proteins. 2017 Sep 5. In: Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Online Appendix 12A.

Table 1

GPI-anchored protein
Protozoa
Trypanosoma brucei variant surface glycoprotein (VSG)	protective coat
Leishmania major promastigote surface protease (PSP)	bound complement degradation
Trypanosoma cruzi GPI-anchored mucins	host cell invasion
Plasmodium falciparum merozoite surface protein 1 (MSP-1)	erythrocyte invasion
Toxoplasma gondii surface antigen 1 (SAG-1)	host cell invasion
Entamoeba histolytica GPI proteophosphoglycans	virulence factor
Yeast, fungi, slime mold
Saccharomyces cerevisiae α-agglutinin	adhesion molecule
Saccharomyces cerevisiae GAS1p	cell-wall biogenesis
Aspergillus fumigatus GEL1p	cell-wall biogenesis
Candida albicans HWP1	adhesion molecule
Dictyostelium discoideum prespore antigen (PsA)	adhesion molecule
Dictyostelium discoideum contact site A (CsA)	adhesion molecule
Plants
Pyrus arabinogalactan proteins (AGPs)	cell-wall biogenesis
Arabidopsis thaliana metallo and aspartyl proteases	pollen tube development
Arabidopsis thaliana β1-3 glucanase	cell-wall biogenesis
Animals (nonmammalian)
Schistosoma mansoni gp200	praziquantel drug target
Caenorhabditis elegans odorant response abnormal 2 (ODR-2)	olfaction
Torpedo marmorata acetylcholinesterase (AchE)	hydrolase
Mammals
Erythrocyte CD59 and decay acceleration factor (DAF)	complement regulation
Alkaline phosphatase	cell-surface hydrolase
5′-Nucleotidase	cell-surface hydrolase
Renal dipeptidase	cell-surface hydrolase
Trehalase	cell-surface hydrolase
Neural cell adhesion molecule 120 (NCAM-120)^a	adhesion molecule
Neural cell adhesion molecule TAG-1	adhesion molecule
CD58^a	adhesion molecule
FcγIII receptor^a	Fc receptor
Ciliary neurotrophic factor receptor (CNTFR) α subunit	neural receptor
Glial-cell-derived neurotrophic factor receptor (GDNFR) α subunit	neural receptor
CD14	lipopolysaccharide receptor
Prion protein (PrP)	unknown
Glypican family of GPI-anchored proteoglycans	extracellular matrix component

^a: Examples for which differential mRNA splicing can result in transmembrane and GPI-anchored forms of the same protein.