Glycosylation Genes Essential for Mouse Embryonic Development

Michael Pierce; Pamela Stanley

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Online Appendix 27AGlycosylation Genes Essential for Mouse Embryonic Development

Pierce M, Stanley P.

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Reference List

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Author Information and Affiliations

Authors

Michael Pierce and Pamela Stanley.

Publication History

Published online: September 5, 2017.

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Cold Spring Harbor Laboratory Press, Cold Spring Harbor (NY)

NLM Citation

Pierce M, Stanley P. Glycosylation Genes Essential for Mouse Embryonic Development. 2017 Sep 5. In: Varki A, Cummings RD, Esko JD, et al., editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Online Appendix 27A.

Gene	Glycan substrate accumulated	Glycan(s) not generated	Stage of death	Reference(s)
N-glycans
Mpi	fructose-6-P	Man-6-P	~E11.5	DeRossi et al. 2006
Pmm2	Man-6-P	Man-1-P	~E3.5	Thiel et al. 2006
Dpagt1	Dol-P	GlcNAc-P-P-Dol	E4-5	Marek et al. 1999
Mgat1	Man₅GlcNAc₂Asn	GlcNAc-Man₅GlcNAc₂Asn	~E9.5	Ioffe and Stanley 1994; Metzler et al. 1994
Man2a1+ Man2a2	GlcNAcMan₅GlcNAc₂Asn	GlcNAc-Man₃GlcNAc₂Asn	E15.5-18.5-P0	Akama et al. 2006
GPI-anchors
Piga	naked GPI-anchor	GlcNAc-GPI-anchor	E7.5-9.5	Nozaki et al. 1999
O-GalNAc glycans
C1galt1	GalNAc-O-Ser/Thr	Gal-GalNAc-Ser/Thr	~E13.5	Xia et al. 2004
C1galt1c1	GalNAc-O-Ser/Thr	Gal-GalNAc-Ser/Thr	~E13.5	Wang et al. 2010
O-fucose glycans
Pofut1	C₂XXXXS/TC₃ EGF repeats	Fuc-O-EGF	~E9.5	Shi and Stanley 2003
Lfng	Fuc-O-EGF	GlcNAc-Fuc-O-EGF	≤P0	Evrard et al. 1998; Zhang and Gridley 1998
Pofut2	TSR type 1 repeats	Fuc-O-TSR type 1	~E6.5	Du et al. 2010
O-mannose glycans
Pomt1	unmodified Ser/Thr	Man-O-Ser/Thr	E7.5-9.5	Willer et al. 2004
Pomt2	unmodified Ser/Thr	Man-O-Ser/Thr	~E9.5	Hu et al. 2011
B4gat1	Xyl-Rbo5P-Rbo5P-GalNAc-GlcNAc-Man(P)-O-Ser/Thr	priming GlcA for XlyGlcA matriglycan added by LARGE	~E9.5	Wright et al. 2012; Willer et al. 2014; Kanagawa et al. 2016
O-glucose glycans
Poglut1	C₁XSXPTC₂ EGF repeats	Glc-O-EGF repeat	~E10.5	Fernandez-Valdivia et al. 2011
Glycosamino-glycans (GAGs)
Ext1	core GAG lacks HS	HS	E6.5-8.5	Lin et al. 2000
Ext2	core GAG lacks HS	HS	E6.5-8.5	Stickens et al. 2005
Ndst1+Ndst2	no N sulfation of HS	HS with GlcNS	~E12.5	Holmborn et al. 2004
Hs6st1	reduced 6-O-sulfation GlcN in HS	HS with GlcN6S	≥E15.5	Habuchi et al. 2007
Hs6st1+Hs2st	very reduced 2-O- and 6-O-sulfation GlcN in HS	HS with GlcN-O-2S and GlcN-O-6S	<E15,5	Conway et al. 2011
Chst11	reduced 4-O-sulfation of GalN in CS	CS with GalN-O-4S	~P0	Bian et al. 2011
Glycolipids
Ugcg	Ceramide lacks Glc	Glc-Cer	≤E9.5	Yamashita et al. 1999
B3gnt5	GalGlc-Cer	GlcNAc-Gal-Glc-Cer	~E3.5	Biellmann et al. 2008
B4galt5	GlcNAcGalGlc-Cer	Gal-GlcNAc-Gal-Glc-Cer	~E10.5	Kumagai et al. 2009; Nishie et al. 2010
Nucleotide sugars
Gne	Mannosamine	GCs without sialic acid	~E9.5	Schwarzkopf et al. 2002
Ugdh	UDP-Glc	UDP-GlcA	~E4.5	Garcia-Garcia and Anderson 2003
Slc35c1	GDP-Fuc	GCs with little Fuc	~P0	Hellbusch et al. 2007
Slc35d1	high UDP-GlcA and UDP-GalNAc in cytoplasm	CS GAGs	~P0	Hiraoka et al. 2007