Microbial adhesins recognizing extracellular matrix macromolecules
- PMID: 7833055
- DOI: 10.1016/0955-0674(94)90104-x
Microbial adhesins recognizing extracellular matrix macromolecules
Abstract
Microorganisms express a family of cell-surface adhesins that specifically recognize and bind components of the extracellular matrix. Adhesion of microorganisms to host tissues represents a critical phase in the development of many types of infections. Recent studies have focused on the mechanisms of microbial attachment at a molecular level, including the identification of ligand-binding domains in several cell-surface adhesins from Gram-positive bacteria and the construction of adhesin-deficient isogenic mutants.
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