Malaria chemoprophylaxis with chloroquine in young Nigerian children. I. Its effect on mortality, morbidity and the prevalence of malaria
- PMID: 3914860
- DOI: 10.1080/00034983.1985.11811962
Malaria chemoprophylaxis with chloroquine in young Nigerian children. I. Its effect on mortality, morbidity and the prevalence of malaria
Abstract
One hundred and ninety-eight Nigerian children who received weekly chemoprophylaxis with chloroquine from shortly after birth until the age of one year or two years and 185 age-matched controls were studied. Chemoprophylaxis with chloroquine was partially, but not completely, effective in controlling malaria. Clinical malaria was documented significantly less frequently in protected children than in control children, and only 9% of random blood films obtained from protected children were positive for Plasmodium falciparum while 41% of random blood films from control children were positive for this parasite. Mean malaria antibody levels were lower in protected than in control children; for ELISA and precipitin antibodies the difference between the two groups was less marked at two years than at one year. Mortality was similar among protected and among control children. No rebound mortality or morbidity was observed after chemoprophylaxis was stopped.
Similar articles
-
Malaria chemoprophylaxis with chloroquine in young Nigerian children. IV. Its effect on haematological measurements.Ann Trop Med Parasitol. 1985 Dec;79(6):585-95. doi: 10.1080/00034983.1985.11811965. Ann Trop Med Parasitol. 1985. PMID: 3834842 Clinical Trial.
-
Malaria chemoprophylaxis with chloroquine in young Nigerian children. III. Its effect on nutrition.Ann Trop Med Parasitol. 1985 Dec;79(6):575-84. doi: 10.1080/00034983.1985.11811964. Ann Trop Med Parasitol. 1985. PMID: 3938935 Clinical Trial.
-
Effect of malaria chemoprophylaxis on the development of antibodies to Plasmodium falciparum in expatriates living in west Africa.Am J Trop Med Hyg. 1990 Jan;42(1):28-35. doi: 10.4269/ajtmh.1990.42.28. Am J Trop Med Hyg. 1990. PMID: 2405726
-
[Current information on treatment and prophylaxis of malaria (author's transl)].MMW Munch Med Wochenschr. 1979 Dec 14;121(50):1679-84. MMW Munch Med Wochenschr. 1979. PMID: 120502 Review. German.
-
Antimalarial chemoprophylaxis in infants and children.Paediatr Drugs. 2001;3(2):113-21. doi: 10.2165/00128072-200103020-00004. Paediatr Drugs. 2001. PMID: 11269638 Review.
Cited by
-
Epidemiology of plasmodium-helminth co-infection in Africa: populations at risk, potential impact on anemia, and prospects for combining control.Am J Trop Med Hyg. 2007 Dec;77(6 Suppl):88-98. Am J Trop Med Hyg. 2007. PMID: 18165479 Free PMC article. Review.
-
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217. Cochrane Database Syst Rev. 2022. PMID: 36321557 Free PMC article.
-
Between traditional remedies and pharmaceutical drugs: prevention and treatment of "Palu" in households in Benin, West Africa.BMC Public Health. 2020 Sep 18;20(1):1425. doi: 10.1186/s12889-020-09479-7. BMC Public Health. 2020. PMID: 32948153 Free PMC article.
-
School-based screening and treatment may reduce P. falciparum transmission.Sci Rep. 2021 Mar 25;11(1):6905. doi: 10.1038/s41598-021-86450-5. Sci Rep. 2021. PMID: 33767384 Free PMC article. Clinical Trial.
-
Intermittent preventive treatment for malaria in children living in areas with seasonal transmission.Cochrane Database Syst Rev. 2012 Feb 15;2012(2):CD003756. doi: 10.1002/14651858.CD003756.pub4. Cochrane Database Syst Rev. 2012. PMID: 22336792 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical