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Review

Amisulpride: Short Chapter

No authors listed
In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012.
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Review

Amisulpride: Short Chapter

No authors listed.
Free Books & Documents

Excerpt

Amisulpride is an intravenously administered dopamine receptor 2 antagonist used for the prevention and therapy of postoperative nausea and vomiting. Amisulpride when given in single doses intravenously has not been associated with serum aminotransferase elevations or with instances of clinically apparent liver.

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References

    1. FDA. Integrated Review. 2020.
    1. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/209510Orig1s000M... [ (FDA integrated review of the data on safety and efficacy of intravenous amisulpride submitted in support of the application for approval as therapy of postoperative nausea and vomiting states that among 1924 patients who received amisulpride there were “no clinically important changes in clinical chemistry values between baseline and post operation” and that extrapyramidal symptoms were uncommon and mild, and rates were similar between placebo and amisulpride treated patients). ]
    1. Coulouvrat C, Dondey-Nouvel L. Safety of amisulpride (Solian): a review of 11 clinical studies. Int Clin Psychopharmacol. 1999;14:209-18. - PubMed
    1. Mortimer A, Martin S, Lôo H, Peuskens J; SOLIANOL Study Group. A double-blind, randomized comparative trial of amisulpride versus olanzapine for 6 months in the treatment of schizophrenia. Int Clin Psychopharmacol. 2004;19:63-9. - PubMed
    1. Musshoff F, Doberentz E, Madea B. Lethal neuroleptic malignant syndrome due to amisulpride. Forensic Sci Med Pathol. 2013;9:218-20. - PubMed

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