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Review
. 2022 Sep 21;9(10):489.
doi: 10.3390/bioengineering9100489.

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

Irina Atkinson  1
Affiliations
Review

Antibiofilm Activity of Biocide Metal Ions Containing Bioactive Glasses (BGs): A Mini Review

Irina Atkinson. Bioengineering (Basel). .

Abstract

One of the major clinical issues during the implantation procedure is the bacterial infections linked to biofilms. Due to their tissue localization and the type of bacteria involved, bacterial infections at implant sites are usually difficult to treat, which increases patient morbidity and even mortality. The difficulty of treating biofilm-associated infections and the emergence of multidrug-resistant bacteria are further challenges for the scientific community to develop novel biomaterials with excellent biocompatibility and antibacterial properties. Given their ability to stimulate bone formation and have antibacterial properties, metal ion-doped bioactive glasses (BGs) have received considerable research. This mini review aims to be successful in presenting the developments made about the role of biocide metal ions incorporated into BGs against the development of bacterial biofilms and the spread of nosocomial diseases.

Keywords: bacterial biofilm; bioactive glass; metal ions.

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Figure 1
Figure 1
The stages of biofilm formation (created with BioRender.com (accessed on 1 September 2022)).
Figure 2
Figure 2
Graphic representation of the antibacterial mechanism of metal ions (created with BioRender.com (accessed on 1 September 2022). (1) metal ion release from BG; (2) direct interaction of the metal ions with the cell wall (3) generation of ROS (extracellular and intracellular); (4) elevated levels of metal ions and ROS generate the disruption of the cell wall and leaking of cellular content; (5) high level of ROS causes loss of the proton motive force and dysfunction of electron transport; (6) depending on metal ions uptake, bacterial proteins and DNA are damaged, leading to the death of the bacteria.
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This research received no external funding.

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