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Review
. 2022 May 17;39(5):84.
doi: 10.1007/s12032-022-01681-4.

The role of histone deacetylase 3 in breast cancer

Rezgar Rahbari  1 , Yousef Rasmi  1 , Mohammad Hassan Khadem-Ansari  2 , Mohammad Abdi  3   4
Affiliations
Review

The role of histone deacetylase 3 in breast cancer

Rezgar Rahbari et al. Med Oncol. .

Abstract

It has been recently revealed that Histone Deacetylase (HDAC) 3, a unique member of the HDACs family, can trigger and progress cancers by alternation in genes expression and proteins activity. Epigenetic modifications by HDACs have been studied well in various cancer cells. Recent studies have focused on the HDAC enzymes as a possible target in cancer therapy. There are significant documents on upregulation of HDAC3 in breast cancer (BC) cells which suggest an oncogenic role for this enzyme. Interestingly, some studies showed that HDAC3 inhibition could be considered as a promising target in breast cancer therapy, and thus far, several inhibitors from different nature have been introduced. In this review, we discussed the function and highlight the existing inhibitors of HDAC3 in BC pathogenesis and therapy.

Keywords: Breast cancer; HDAC; HDAC3; HDAC3 inhibitors.

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