Friends or enemies? The complicated relationship between Pseudomonas aeruginosa and Staphylococcus aureus

doi:10.1111/mmi.14699

Review

. 2021 Jul;116(1):1-15.

doi: 10.1111/mmi.14699. Epub 2021 Mar 8.

Friends or enemies? The complicated relationship between Pseudomonas aeruginosa and Staphylococcus aureus

Deborah Bow Yue Yung¹, Kathleen Jean Sircombe¹, Daniel Pletzer¹

Affiliations

PMID: 33576132
DOI: 10.1111/mmi.14699

Free article

Review

Friends or enemies? The complicated relationship between Pseudomonas aeruginosa and Staphylococcus aureus

Deborah Bow Yue Yung et al. Mol Microbiol. 2021 Jul.

Free article

. 2021 Jul;116(1):1-15.

doi: 10.1111/mmi.14699. Epub 2021 Mar 8.

Authors

Deborah Bow Yue Yung¹, Kathleen Jean Sircombe¹, Daniel Pletzer¹

Affiliation

¹ Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.

PMID: 33576132
DOI: 10.1111/mmi.14699

Abstract

Pseudomonas aeruginosa (Pa) and Staphylococcus aureus (Sa) are opportunistic pathogens that are most commonly co-isolated from chronic wounds and the sputum of cystic fibrosis patients. Over the last few years, there have been plenty of contrasting results from studies involving P. aeruginosa and S. aureus co-cultures. The general concept that P. aeruginosa outcompetes S. aureus has been challenged and there is more evidence now that they can co-exist. Nevertheless, it still remains difficult to mimic polymicrobial infections in vitro and in vivo. In this review, we discuss recent advances in regard to Pa-Sa molecular interactions, their physical responses, and in vitro and in vivo models. We believe it is important to optimize growth conditions in the laboratory, determine appropriate bacterial starting ratios, and consider environmental factors to study the co-existence of these two pathogens. Ideally, optimized growth media should reflect host-mimicking conditions with or without host cells that allow both bacteria to co-exist. To further identify mechanisms that could help to treat these complex infections, we propose to use relevant polymicrobial animal models. Ultimately, we briefly discuss how polymicrobial infections can increase antibiotic tolerance.

Keywords: animal models; antibiotic tolerance; biofilms; chronic wounds; cystic fibrosis; host-mimicking conditions; polymicrobial interactions.

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References

REFERENCES

1. Akita, S., Tanaka, K. & Hirano, A. (2006) Lower extremity reconstruction after necrotising fasciitis and necrotic skin lesions using a porcine-derived skin substitute. Journal of Plastic, Reconstructive & Aesthetic Surgery, 59, 759-763. Available from: https://doi.org/10.1016/j.bjps.2005.11.021.
1. Alves, P.M., Al-Badi, E., Withycombe, C., Jones, P.M., Purdy, K.J. & Maddocks, S.E. (2018) Interaction between Staphylococcus aureus and Pseudomonas aeruginosa is beneficial for colonisation and pathogenicity in a mixed biofilm. Pathogens and Disease, 76, fty003. Available from: https://doi.org/10.1093/femspd/fty003.
1. Ammann, C.G., Nagl, M., Nogler, M. & Coraca-Huber, D.C. (2016) Pseudomonas aeruginosa outcompetes other bacteria in the manifestation and maintenance of a biofilm in polyvinylchloride tubing as used in dental devices. Archives of Microbiology, 198, 389-391. Available from: https://doi.org/10.1007/s00203-016-1208-6.
1. Armbruster, C.E., Hong, W., Pang, B., Weimer, K.E., Juneau, R.A., Turner, J. et al. (2010) Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. mBio, 1, e00102-10. Available from: https://doi.org/10.1128/mBio.00102-10.
1. Armbruster, C.R., Wolter, D.J., Mishra, M., Hayden, H.S., Radey, M.C., Merrihew, G. et al. (2016) Staphylococcus aureus protein A mediates interspecies interactions at the cell surface of Pseudomonas aeruginosa. mBio, 7, e00538-16.

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[1] Akita, S., Tanaka, K. & Hirano, A. (2006) Lower extremity reconstruction after necrotising fasciitis and necrotic skin lesions using a porcine-derived skin substitute. Journal of Plastic, Reconstructive & Aesthetic Surgery, 59, 759-763. Available from: https://doi.org/10.1016/j.bjps.2005.11.021.

[2] Akita, S., Tanaka, K. & Hirano, A. (2006) Lower extremity reconstruction after necrotising fasciitis and necrotic skin lesions using a porcine-derived skin substitute. Journal of Plastic, Reconstructive & Aesthetic Surgery, 59, 759-763. Available from: https://doi.org/10.1016/j.bjps.2005.11.021.

[3] Alves, P.M., Al-Badi, E., Withycombe, C., Jones, P.M., Purdy, K.J. & Maddocks, S.E. (2018) Interaction between Staphylococcus aureus and Pseudomonas aeruginosa is beneficial for colonisation and pathogenicity in a mixed biofilm. Pathogens and Disease, 76, fty003. Available from: https://doi.org/10.1093/femspd/fty003.

[4] Alves, P.M., Al-Badi, E., Withycombe, C., Jones, P.M., Purdy, K.J. & Maddocks, S.E. (2018) Interaction between Staphylococcus aureus and Pseudomonas aeruginosa is beneficial for colonisation and pathogenicity in a mixed biofilm. Pathogens and Disease, 76, fty003. Available from: https://doi.org/10.1093/femspd/fty003.

[5] Ammann, C.G., Nagl, M., Nogler, M. & Coraca-Huber, D.C. (2016) Pseudomonas aeruginosa outcompetes other bacteria in the manifestation and maintenance of a biofilm in polyvinylchloride tubing as used in dental devices. Archives of Microbiology, 198, 389-391. Available from: https://doi.org/10.1007/s00203-016-1208-6.

[6] Ammann, C.G., Nagl, M., Nogler, M. & Coraca-Huber, D.C. (2016) Pseudomonas aeruginosa outcompetes other bacteria in the manifestation and maintenance of a biofilm in polyvinylchloride tubing as used in dental devices. Archives of Microbiology, 198, 389-391. Available from: https://doi.org/10.1007/s00203-016-1208-6.

[7] Armbruster, C.E., Hong, W., Pang, B., Weimer, K.E., Juneau, R.A., Turner, J. et al. (2010) Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. mBio, 1, e00102-10. Available from: https://doi.org/10.1128/mBio.00102-10.

[8] Armbruster, C.E., Hong, W., Pang, B., Weimer, K.E., Juneau, R.A., Turner, J. et al. (2010) Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling. mBio, 1, e00102-10. Available from: https://doi.org/10.1128/mBio.00102-10.

[9] Armbruster, C.R., Wolter, D.J., Mishra, M., Hayden, H.S., Radey, M.C., Merrihew, G. et al. (2016) Staphylococcus aureus protein A mediates interspecies interactions at the cell surface of Pseudomonas aeruginosa. mBio, 7, e00538-16.

[10] Armbruster, C.R., Wolter, D.J., Mishra, M., Hayden, H.S., Radey, M.C., Merrihew, G. et al. (2016) Staphylococcus aureus protein A mediates interspecies interactions at the cell surface of Pseudomonas aeruginosa. mBio, 7, e00538-16.

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Friends or enemies? The complicated relationship between Pseudomonas aeruginosa and Staphylococcus aureus

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Friends or enemies? The complicated relationship between Pseudomonas aeruginosa and Staphylococcus aureus

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