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Practice Guideline
. 2013 Jan;28(1):5-11.
doi: 10.1007/s00467-012-2138-4. Epub 2012 Mar 30.

Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative

Clifford E Kashtan  1 , Jie Ding, Martin Gregory, Oliver Gross, Laurence Heidet, Bertrand Knebelmann, Michelle Rheault, Christoph Licht; Alport Syndrome Research Collaborative
Affiliations
Practice Guideline

Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative

Clifford E Kashtan et al. Pediatr Nephrol. 2013 Jan.

Abstract

We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatment protocol is based on the reduction of proteinuria, intraglomerular pressure, and renal fibrosis via interference with the renin-angiotensin-aldosterone system.

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Figures

Fig. 1
Fig. 1
Algorithm for identifying children with familial hematuria (Alport syndrome or hematuria with thin glomerular basement membranes) who are candidates for intervention. IHC immunohistochemistry; EM electron microscopy; GBM glomerular basement membrane *Depending upon availability and local practice
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