Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Nov 13:2010:177-81.

ADESSA: A Real-Time Decision Support Service for Delivery of Semantically Coded Adverse Drug Event Data

Jon D Duke  1 , Jeff Friedlin
Affiliations

ADESSA: A Real-Time Decision Support Service for Delivery of Semantically Coded Adverse Drug Event Data

Jon D Duke et al. AMIA Annu Symp Proc. .

Abstract

Evaluating medications for potential adverse events is a time-consuming process, typically involving manual lookup of information by physicians. This process can be expedited by CDS systems that support dynamic retrieval and filtering of adverse drug events (ADE's), but such systems require a source of semantically-coded ADE data. We created a two-component system that addresses this need. First we created a natural language processing application which extracts adverse events from Structured Product Labels and generates a standardized ADE knowledge base. We then built a decision support service that consumes a Continuity of Care Document and returns a list of patient-specific ADE's. Our database currently contains 534,125 ADE's from 5602 product labels. An NLP evaluation of 9529 ADE's showed recall of 93% and precision of 95%. On a trial set of 30 CCD's, the system provided adverse event data for 88% of drugs and returned these results in an average of 620ms.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Input and primary modules of the Structured Product Label Information Coder and Extractor (SPLICER).
Figure 2.
Figure 2.
Excerpt from a Continuity of Care Document containing RxNorm-coded medication data.
Figure 3.
Figure 3.
Sample ADESSA results displaying SNOMED-coded adverse events for promethazine.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Aronson JK, Derry S, Loke YK. Adverse drug reactions: keeping up to date. Fundamental and Clinical Pharmacology. 2002;16(1):49–56. - PubMed
    1. Strasberg HR, Hubbs PR, Rindfleisch TC, Melmon KL. Analysis of information needs of users of the Stanford Health Information Network for Education. Proc AMIA Symp. 1999:965–969. - PMC - PubMed
    1. Zarowitz BJ, Stebelsky LA, Muma BK, Romain TM, Peterson EL. Reduction of high-risk polypharmacy drug combinations in patients in a managed care setting. Pharmacotherapy. 2005;25(11):1636–45. - PubMed
    1. Ely JW, Osheroff JA, Chambliss ML, Ebell MH, Rosenbaum ME. Answering Physicians’ Clinical Questions: Obstacles and Potential Solutions. J Am Med Inform Assoc. 2005;12(2):217–224. - PMC - PubMed
    1. Ramos K, Linscheid R, Schafer S. Real-time information-seeking behavior of residency physicians. Fam Med. 2003;35(4):257–60. - PubMed

LinkOut - more resources