Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Dilated Cardiomyopathy Overview

In: GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993.
[updated ].
Affiliations
Free Books & Documents
Review

Dilated Cardiomyopathy Overview

Ray E Hershberger et al.
Free Books & Documents

Excerpt

The purpose of this overview is to:

  1. 1

    Define DCM;

  2. 2

    Identify the categories of DCM;

  3. 3

    Provide the evaluation strategy of a proband with nonsyndromic DCM;

  4. 4

    Provide a basic view of genetic risk assessment of at-risk asymptomatic relatives of a proband with DCM to inform cardiac surveillance and allow early detection and treatment of DCM to improve long-term outcome.

PubMed Disclaimer

Similar articles

  • Nonsyndromic Hypertrophic Cardiomyopathy Overview.
    Cirino AL, Channaoui N, Ho C. Cirino AL, et al. 2008 Aug 5 [updated 2025 Mar 6]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2008 Aug 5 [updated 2025 Mar 6]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 20301725 Free Books & Documents. Review.
  • Genetic variants in Chinese patients with sporadic dilated cardiomyopathy: a cross-sectional study.
    Shen C, Xu L, Sun X, Sun A, Ge J. Shen C, et al. Ann Transl Med. 2022 Feb;10(3):129. doi: 10.21037/atm-21-6774. Ann Transl Med. 2022. PMID: 35284542 Free PMC article.
  • Evaluation of 15 candidate genes for dilated cardiomyopathy in the Newfoundland dog.
    Wiersma AC, Stabej P, Leegwater PA, Van Oost BA, Ollier WE, Dukes-McEwan J. Wiersma AC, et al. J Hered. 2008 Jan-Feb;99(1):73-80. doi: 10.1093/jhered/esm090. Epub 2007 Nov 12. J Hered. 2008. PMID: 17998275
  • Limb-Girdle Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY.
    Pegoraro E, Hoffman EP. Pegoraro E, et al. 2000 Jun 8 [updated 2012 Aug 30]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2000 Jun 8 [updated 2012 Aug 30]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 20301582 Free Books & Documents. Review.
  • Dystrophinopathies.
    Darras BT, Urion DK, Ghosh PS. Darras BT, et al. 2000 Sep 5 [updated 2022 Jan 20]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2000 Sep 5 [updated 2022 Jan 20]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 20301298 Free Books & Documents. Review.

References

    1. Alkhunaizi E, Martin N, Jelin AC, Rosner M, Bailey DJ, Steiner LA, Lakhani S, Ji W, Katzman PJ, Forster KR, Jarinova O, Shannon P, Chitayat D; Care4Rare Canada Consortium. Fetal akinesia deformation sequence syndrome associated with recessive TTN variants. Am J Med Genet A. 2023;191:760-9. - PMC - PubMed
    1. Burkett EL, Hershberger RE. Clinical and genetic issues in familial dilated cardiomyopathy. J Am Coll Cardiol. 2005;45:969-81. - PubMed
    1. Caleshu C, Day S, Rehm HL, Baxter S. Use and interpretation of genetic tests in cardiovascular genetics. Heart. 2010;96:1669-75. - PubMed
    1. Cowan JR, Kinnamon DD, Morales A, Salyer L, Nickerson DA, Hershberger RE. Multigenic disease and bilineal inheritance in dilated cardiomyopathy is illustrated in nonsegregating LMNA pedigrees. Circ Genom Precis Med. 2018;11:e002038. - PMC - PubMed
    1. Dellefave L, McNally EM. The genetics of dilated cardiomyopathy. Curr Opin Cardiol. 2010;25:198-204. - PMC - PubMed

LinkOut - more resources