Review
doi: 10.1038/nrm2299.
Heterotrimeric G protein activation by G-protein-coupled receptors
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- PMID: 18043707
- DOI: 10.1038/nrm2299
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Review
Heterotrimeric G protein activation by G-protein-coupled receptors
Nat Rev Mol Cell Biol.
2008 Jan.
Abstract
Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these receptors, which then catalyse GTP-GDP exchange on the G protein alpha-subunit. The complex series of interactions and conformational changes that connect agonist binding to G protein activation raise various interesting questions about the structure, biomechanics, kinetics and specificity of signal transduction across the plasma membrane.
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