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. 2006 Jul;113(7):787-801.
doi: 10.1007/s00702-005-0367-4. Epub 2005 Oct 27.

Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)

U Schmitt  1 , A Abou El-Ela, L J Guo, H Glavinas, P Krajcsi, J M Baron, C Tillmann, C Hiemke, P Langguth, S Härtter
Affiliations

Cyclosporine A (CsA) affects the pharmacodynamics and pharmacokinetics of the atypical antipsychotic amisulpride probably via inhibition of P-glycoprotein (P-gp)

U Schmitt et al. J Neural Transm (Vienna). 2006 Jul.

Abstract

The importance of P-glycoprotein (P-gp) in the pharmacokinetics of amisulpride and the effects of a P-gp inhibitor cyclosporine A (CsA) was investigated both, in vitro and in vivo. In vitro and in vivo results indicated amisulpride as a substrate of P-gp. Amisulpride was not metabolized by rat liver microsomes. Open field behavior showed time dependent abolishment in locomotion by amisulpride (50 mg kg(-1)). Co-administration of CsA (50 mg kg(-1)) resulted in a higher and significantly longer antipsychotic effect (24 h after drug administration). Accordingly, the area under concentration-time curve in serum and brain was higher in CsA co-treated rats (13.5 vs. 29.8 micromol h l(-1) for serum and 2.16 vs 2.98 micromol h l(-1) for brain tissue) while renal clearance was not affected. These results pointed to a pharmacokinetic drug interaction between CsA and amisulpride most likely caused by inhibition of P-gp.

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References

    1. J Pharm Pharmacol. 2004 Aug;56(8):967-75 - PubMed
    1. J Clin Invest. 1996 Jun 1;97(11):2517-24 - PubMed
    1. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37 - PubMed
    1. Int J Clin Pharmacol Ther. 1998 Jan;36(1):16-24 - PubMed
    1. Adv Drug Deliv Rev. 1999 Apr 5;36(2-3):195-209 - PubMed

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