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Case Reports
. 2004 Nov;73(5):380-3.
doi: 10.1111/j.1600-0609.2004.00310.x.

Long-term alpha interferon treatment is effective on anaemia and significantly reduces iron overload in congenital dyserythropoiesis type I

Thierry Lavabre-Bertrand  1 , Jeanne Ramos, Christophe Delfour, Laurent Henry, Isabelle Guiraud, Serge Carillo, André Wagner, Jean Paul Bureau, Pierre Blanc
Affiliations
Case Reports

Long-term alpha interferon treatment is effective on anaemia and significantly reduces iron overload in congenital dyserythropoiesis type I

Thierry Lavabre-Bertrand et al. Eur J Haematol. 2004 Nov.

Abstract

Interferon has been shown to be an effective treatment of congenital dyserythropoiesis type I (CDA-I), but the optimal dose and the feasibility of this treatment remains to be determined. Here, in a 9-yr follow-up of a single patient, we show that interferon remains active during such a long period. The optimal dose of conventional alpha interferon could be evaluated at 2 million units twice a week. Pegylated interferon could be used as well at a dose of 30 microg/wk. During interferon treatment, serum and erythrocyte ferritin levels decreased progressively, and remained inversely correlated with haemoglobin levels. On repeated liver biopsies, iron overload could be normalized. Low dose interferon is a long-term treatment of CDA-I, and allows a significant decrease in iron overload, that could be interesting even in patients who are only moderately anaemic.

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