Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteins
- PMID: 12547421
- DOI: 10.1016/s1367-5931(02)00018-2
Emergence of diverse biochemical activities in evolutionarily conserved structural scaffolds of proteins
Abstract
Comparative analysis of numerous protein structures that have become available in the past few years, combined with genome comparison, has yielded new insights into the evolution of enzymes and their functions. In addition to the well-known diversification of substrate specificities, enzymes with several widespread catalytic folds, particularly the TIM barrel, the RRM-like domain and the double-stranded beta-helix (cupin) domain, have been extensively explored in 'reaction space', resulting in the evolution of numerous, diverse catalytic activities supported by the same structural scaffold. Common protein folds differ widely in the diversity of catalyzed reactions. The biochemical plasticity of a fold seems to hinge on the presence of a generic, symmetrical substrate-binding pocket as opposed to highly specialized binding sites.
Similar articles
-
One fold with many functions: the evolutionary relationships between TIM barrel families based on their sequences, structures and functions.J Mol Biol. 2002 Aug 30;321(5):741-65. doi: 10.1016/s0022-2836(02)00649-6. J Mol Biol. 2002. PMID: 12206759 Review.
-
The emergence of catalytic and structural diversity within the beta-clip fold.Proteins. 2004 Jun 1;55(4):977-91. doi: 10.1002/prot.20076. Proteins. 2004. PMID: 15146494
-
Divergence and convergence in enzyme evolution.J Biol Chem. 2012 Jan 2;287(1):21-28. doi: 10.1074/jbc.R111.241976. Epub 2011 Nov 8. J Biol Chem. 2012. PMID: 22069324 Free PMC article. Review.
-
Evolutionary markers in the (beta/alpha)8-barrel fold.Curr Opin Chem Biol. 2003 Dec;7(6):694-701. doi: 10.1016/j.cbpa.2003.10.004. Curr Opin Chem Biol. 2003. PMID: 14644177 Review.
-
Diversification of catalytic activities and ligand interactions in the protein fold shared by the sugar isomerases, eIF2B, DeoR transcription factors, acyl-CoA transferases and methenyltetrahydrofolate synthetase.J Mol Biol. 2006 Feb 24;356(3):823-42. doi: 10.1016/j.jmb.2005.11.031. Epub 2005 Dec 1. J Mol Biol. 2006. PMID: 16376935
Cited by
-
Divergent Stereoselectivity in Phosphothreonine (pThr)-Catalyzed Reductive Aminations of 3-Amidocyclohexanones.J Org Chem. 2018 Apr 20;83(8):4491-4504. doi: 10.1021/acs.joc.8b00207. Epub 2018 Apr 5. J Org Chem. 2018. PMID: 29547285 Free PMC article.
-
Urtica dioica L. inhibits proliferation and enhances cisplatin cytotoxicity in NSCLC cells via Endoplasmic Reticulum-stress mediated apoptosis.Sci Rep. 2019 Mar 21;9(1):4986. doi: 10.1038/s41598-019-41372-1. Sci Rep. 2019. PMID: 30899059 Free PMC article.
-
Two distinct mechanisms for TIM barrel prenyltransferases in bacteria.J Am Chem Soc. 2011 Feb 9;133(5):1270-3. doi: 10.1021/ja109578b. Epub 2011 Jan 7. J Am Chem Soc. 2011. PMID: 21214173 Free PMC article.
-
Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD.PLoS One. 2017 Sep 26;12(9):e0185226. doi: 10.1371/journal.pone.0185226. eCollection 2017. PLoS One. 2017. PMID: 28949991 Free PMC article.
-
Common Patterns of Hydrolysis Initiation in P-loop Fold Nucleoside Triphosphatases.Biomolecules. 2022 Sep 22;12(10):1345. doi: 10.3390/biom12101345. Biomolecules. 2022. PMID: 36291554 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
