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Clinical Trial
. 2001 Apr;97(4):577-82.
doi: 10.1016/s0029-7844(00)01228-x.

Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial

T Vutyavanich  1 , T Kraisarin, R Ruangsri
Affiliations
Clinical Trial

Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebo-controlled trial

T Vutyavanich et al. Obstet Gynecol. 2001 Apr.

Abstract

Objective: To determine the effectiveness of ginger for the treatment of nausea and vomiting of pregnancy.

Methods: Women with nausea and vomiting of pregnancy, who first attended an antenatal clinic at or before 17 weeks' gestation, were invited to participate in the study. During a 5-month period, 70 eligible women gave consent and were randomized in a double-masked design to receive either oral ginger 1 g per day or an identical placebo for 4 days. Subjects graded the severity of their nausea using visual analog scales and recorded the number of vomiting episodes in the previous 24 hours before treatment, and again during 4 consecutive days while taking treatment. At a follow-up visit 7 days later, five-item Likert scales were used to assess the severity of their symptoms.

Results: All participants except three in the placebo group remained in the study. The visual analog scores of posttherapy minus baseline nausea decreased significantly in the ginger group (2.1 +/- 1.9) compared with the placebo group (0.9 +/- 2.2, P =.014). The number of vomiting episodes also decreased significantly in the ginger group (1.4 +/- 1.3) compared with the placebo group (0.3 +/- 1.1, P <.001). Likert scales showed that 28 of 32 in the ginger group had improvement in nausea symptoms compared with 10 of 35 in the placebo group (P <.001). No adverse effect of ginger on pregnancy outcome was detected.

Conclusion: Ginger is effective for relieving the severity of nausea and vomiting of pregnancy.

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