Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Aug;6(8):729-34.
doi: 10.1038/11495.

Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ

C Tomomori  1 , T Tanaka, R Dutta, H Park, S K Saha, Y Zhu, R Ishima, D Liu, K I Tong, H Kurokawa, H Qian, M Inouye, M Ikura
Affiliations

Solution structure of the homodimeric core domain of Escherichia coli histidine kinase EnvZ

C Tomomori et al. Nat Struct Biol. 1999 Aug.

Abstract

Escherichia coli osmosensor EnvZ is a protein histidine kinase that plays a central role in osmoregulation, a cellular adaptation process involving the His-Asp phosphorelay signal transduction system. Dimerization of the transmembrane protein is essential for its autophosphorylation and phosphorelay signal transduction functions. Here we present the NMR-derived structure of the homodimeric core domain (residues 223-289) of EnvZ that includes His 243, the site of autophosphorylation and phosphate transfer reactions. The structure comprises a four-helix bundle formed by two identical helix-turn-helix subunits, revealing the molecular assembly of two active sites within the dimeric kinase.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

Associated data

LinkOut - more resources