Name: rs1903858
Published: September 21, 2022
License: Open Access

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs1903858

Current Build 156

Released September 21, 2022

Organism: Homo sapiens
Position: chr10:87893929 (GRCh38.p14) Help
The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.
Alleles: A>C / A>G / A>T
Variation Type: SNV Single Nucleotide Variation
Frequency: G=0.393177 (104070/264690, TOPMED)
G=0.332970 (47700/143256, ALFA)
G=0.389601 (53218/136596, GnomAD) (+ 19 more)
A=0.48425 (13684/28258, 14KJPN)
A=0.47822 (8015/16760, 8.3KJPN)
G=0.4171 (2671/6404, 1000G_30x)
G=0.4179 (2093/5008, 1000G)
G=0.2849 (1276/4478, Estonian)
G=0.3189 (1229/3854, ALSPAC)
G=0.3269 (1212/3708, TWINSUK)
G=0.4560 (1336/2930, KOREAN)
G=0.4487 (822/1832, Korea1K)
G=0.4627 (819/1770, HapMap)
G=0.327 (326/998, GoNL)
G=0.385 (231/600, NorthernSweden)
G=0.037 (20/534, MGP)
A=0.286 (110/384, SGDP_PRJ)
G=0.486 (105/216, Qatari)
A=0.490 (103/210, Vietnamese)
A=0.50 (20/40, GENOME_DK)
G=0.50 (20/40, GENOME_DK)
A=0.33 (10/30, Siberian)

Clinical Significance: Reported in ClinVar
Gene : Consequence: PTEN : Intron Variant
Publications: 8 citations
Genomic View: See rs on genome

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20231103111315

Population	Group	Sample Size	Ref Allele	Alt Allele	Ref HMOZ	Alt HMOZ	HTRZ	HWEP
Total	Global	143256	A=0.667030	G=0.332970	0.456958	0.122899	0.420143	32
European	Sub	122700	A=0.683733	G=0.316267	0.478517	0.111051	0.410432	32
African	Sub	6608	A=0.5288	G=0.4712	0.281477	0.223971	0.494552	0
African Others	Sub	238	A=0.508	G=0.492	0.277311	0.260504	0.462185	0
African American	Sub	6370	A=0.5295	G=0.4705	0.281633	0.222606	0.495761	0
Asian	Sub	620	A=0.492	G=0.508	0.225806	0.241935	0.532258	1
East Asian	Sub	488	A=0.471	G=0.529	0.204918	0.262295	0.532787	1
Other Asian	Sub	132	A=0.568	G=0.432	0.30303	0.166667	0.530303	0
Latin American 1	Sub	734	A=0.590	G=0.410	0.346049	0.166213	0.487738	0
Latin American 2	Sub	6236	A=0.5513	G=0.4487	0.314625	0.211995	0.47338	4
South Asian	Sub	184	A=0.685	G=0.315	0.445652	0.076087	0.478261	1
Other	Sub	6174	A=0.6262	G=0.3738	0.396825	0.144477	0.458698	1

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

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Study	Population	Group	Sample Size	Ref Allele	Alt Allele
TopMed	Global	Study-wide	264690	A=0.606823	G=0.393177
Allele Frequency Aggregator	Total	Global	143256	A=0.667030	G=0.332970
Allele Frequency Aggregator	European	Sub	122700	A=0.683733	G=0.316267
Allele Frequency Aggregator	African	Sub	6608	A=0.5288	G=0.4712
Allele Frequency Aggregator	Latin American 2	Sub	6236	A=0.5513	G=0.4487
Allele Frequency Aggregator	Other	Sub	6174	A=0.6262	G=0.3738
Allele Frequency Aggregator	Latin American 1	Sub	734	A=0.590	G=0.410
Allele Frequency Aggregator	Asian	Sub	620	A=0.492	G=0.508
Allele Frequency Aggregator	South Asian	Sub	184	A=0.685	G=0.315
gnomAD - Genomes	Global	Study-wide	136596	A=0.610399	G=0.389601
gnomAD - Genomes	European	Sub	73218	A=0.67106	G=0.32894
gnomAD - Genomes	African	Sub	41644	A=0.52949	G=0.47051
gnomAD - Genomes	American	Sub	13268	A=0.55532	G=0.44468
gnomAD - Genomes	Ashkenazi Jewish	Sub	3258	A=0.6262	G=0.3738
gnomAD - Genomes	East Asian	Sub	3120	A=0.4968	G=0.5032
gnomAD - Genomes	Other	Sub	2088	A=0.5920	G=0.4080
14KJPN	JAPANESE	Study-wide	28258	A=0.48425	G=0.51575
8.3KJPN	JAPANESE	Study-wide	16760	A=0.47822	G=0.52178
1000Genomes_30x	Global	Study-wide	6404	A=0.5829	G=0.4171
1000Genomes_30x	African	Sub	1786	A=0.5112	G=0.4888
1000Genomes_30x	Europe	Sub	1266	A=0.6556	G=0.3444
1000Genomes_30x	South Asian	Sub	1202	A=0.7105	G=0.2895
1000Genomes_30x	East Asian	Sub	1170	A=0.4957	G=0.5043
1000Genomes_30x	American	Sub	980	A=0.567	G=0.433
1000Genomes	Global	Study-wide	5008	A=0.5821	G=0.4179
1000Genomes	African	Sub	1322	A=0.5061	G=0.4939
1000Genomes	East Asian	Sub	1008	A=0.4950	G=0.5050
1000Genomes	Europe	Sub	1006	A=0.6521	G=0.3479
1000Genomes	South Asian	Sub	978	A=0.712	G=0.288
1000Genomes	American	Sub	694	A=0.569	G=0.431
Genetic variation in the Estonian population	Estonian	Study-wide	4478	A=0.7151	G=0.2849
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.6811	G=0.3189
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.6731	G=0.3269
KOREAN population from KRGDB	KOREAN	Study-wide	2930	A=0.5440	C=0.0000, G=0.4560, T=0.0000
Korean Genome Project	KOREAN	Study-wide	1832	A=0.5513	G=0.4487
HapMap	Global	Study-wide	1770	A=0.5373	G=0.4627
HapMap	African	Sub	682	A=0.438	G=0.562
HapMap	American	Sub	662	A=0.604	G=0.396
HapMap	Asian	Sub	250	A=0.528	G=0.472
HapMap	Europe	Sub	176	A=0.682	G=0.318
Genome of the Netherlands Release 5	Genome of the Netherlands	Study-wide	998	A=0.673	G=0.327
Northern Sweden	ACPOP	Study-wide	600	A=0.615	G=0.385
Medical Genome Project healthy controls from Spanish population	Spanish controls	Study-wide	534	A=0.963	G=0.037
SGDP_PRJ	Global	Study-wide	384	A=0.286	G=0.714
Qatari	Global	Study-wide	216	A=0.514	G=0.486
A Vietnamese Genetic Variation Database	Global	Study-wide	210	A=0.490	G=0.510
The Danish reference pan genome	Danish	Study-wide	40	A=0.50	G=0.50
Siberian	Global	Study-wide	30	A=0.33	G=0.67

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements

Sequence name	Change
GRCh38.p14 chr 10	NC_000010.11:g.87893929A>C
GRCh38.p14 chr 10	NC_000010.11:g.87893929A>G
GRCh38.p14 chr 10	NC_000010.11:g.87893929A>T
GRCh37.p13 chr 10	NC_000010.10:g.89653686A>C
GRCh37.p13 chr 10	NC_000010.10:g.89653686A>G
GRCh37.p13 chr 10	NC_000010.10:g.89653686A>T
PTEN RefSeqGene (LRG_311)	NG_007466.2:g.35491A>C
PTEN RefSeqGene (LRG_311)	NG_007466.2:g.35491A>G
PTEN RefSeqGene (LRG_311)	NG_007466.2:g.35491A>T
GRCh38.p14 chr 10 fix patch HG2334_PATCH	NW_013171807.1:g.109752A>C
GRCh38.p14 chr 10 fix patch HG2334_PATCH	NW_013171807.1:g.109752A>G
GRCh38.p14 chr 10 fix patch HG2334_PATCH	NW_013171807.1:g.109752A>T

Gene: PTEN, phosphatase and tensin homolog (plus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
PTEN transcript variant 1	NM_000314.8:c.80-96A>C	N/A	Intron Variant
PTEN transcript variant 2	NM_001304717.5:c.600-96A>C	N/A	Intron Variant
PTEN transcript variant 3	NM_001304718.2:c.-626-96A… NM_001304718.2:c.-626-96A>C	N/A	Intron Variant

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Allele: G (allele ID: 433072 )

ClinVar Accession	Disease Names	Clinical Significance
RCV001653874.5	not provided	Benign

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement	A=	C	G	T
GRCh38.p14 chr 10	NC_000010.11:g.87893929=	NC_000010.11:g.87893929A>C	NC_000010.11:g.87893929A>G	NC_000010.11:g.87893929A>T
GRCh37.p13 chr 10	NC_000010.10:g.89653686=	NC_000010.10:g.89653686A>C	NC_000010.10:g.89653686A>G	NC_000010.10:g.89653686A>T
PTEN RefSeqGene (LRG_311)	NG_007466.2:g.35491=	NG_007466.2:g.35491A>C	NG_007466.2:g.35491A>G	NG_007466.2:g.35491A>T
GRCh38.p14 chr 10 fix patch HG2334_PATCH	NW_013171807.1:g.109752=	NW_013171807.1:g.109752A>C	NW_013171807.1:g.109752A>G	NW_013171807.1:g.109752A>T
PTEN transcript	NM_000314.4:c.80-96=	NM_000314.4:c.80-96A>C	NM_000314.4:c.80-96A>G	NM_000314.4:c.80-96A>T
PTEN transcript variant 1	NM_000314.8:c.80-96=	NM_000314.8:c.80-96A>C	NM_000314.8:c.80-96A>G	NM_000314.8:c.80-96A>T
PTEN transcript variant 2	NM_001304717.5:c.600-96=	NM_001304717.5:c.600-96A>C	NM_001304717.5:c.600-96A>G	NM_001304717.5:c.600-96A>T
PTEN transcript variant 3	NM_001304718.2:c.-626-96=	NM_001304718.2:c.-626-96A>C	NM_001304718.2:c.-626-96A>G	NM_001304718.2:c.-626-96A>T

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

124 SubSNP, 21 Frequency, 1 ClinVar submissions

No	Submitter	Submission ID	Date (Build)
1	TSC-CSHL	ss2787378	Jan 12, 2001 (92)
2	YUSUKE	ss3237058	Sep 28, 2001 (100)
3	SC_JCM	ss3464781	Sep 28, 2001 (100)
4	WI_SSAHASNP	ss12083906	Jul 11, 2003 (116)
5	SC_SNP	ss16083263	Feb 27, 2004 (120)
6	PERLEGEN	ss23639050	Sep 20, 2004 (123)
7	EGP_SNPS	ss38349717	Mar 13, 2006 (126)
8	ABI	ss38636209	Mar 13, 2006 (126)
9	SNP500CANCER	ss48296530	Mar 13, 2006 (126)
10	ILLUMINA	ss65758116	Oct 15, 2006 (127)
11	PERLEGEN	ss69086718	May 17, 2007 (127)
12	ILLUMINA	ss74863338	Dec 06, 2007 (129)
13	SI_EXO	ss76890114	Dec 06, 2007 (129)
14	KRIBB_YJKIM	ss80745056	Dec 15, 2007 (130)
15	BCMHGSC_JDW	ss88301756	Mar 23, 2008 (129)
16	SHGC	ss95216435	Feb 06, 2009 (130)
17	KRIBB_YJKIM	ss102645205	Feb 06, 2009 (130)
18	BGI	ss102899696	Dec 01, 2009 (131)
19	1000GENOMES	ss109634293	Jan 24, 2009 (130)
20	1000GENOMES	ss113609472	Jan 25, 2009 (130)
21	ILLUMINA-UK	ss119257624	Feb 15, 2009 (130)
22	GMI	ss155345362	Dec 01, 2009 (131)
23	ILLUMINA	ss160474841	Dec 01, 2009 (131)
24	COMPLETE_GENOMICS	ss170681972	Jul 04, 2010 (132)
25	ILLUMINA	ss172978187	Jul 04, 2010 (132)
26	COMPLETE_GENOMICS	ss174678632	Jul 04, 2010 (132)
27	BUSHMAN	ss201828161	Jul 04, 2010 (132)
28	BCM-HGSC-SUB	ss207346372	Jul 04, 2010 (132)
29	1000GENOMES	ss224860360	Jul 14, 2010 (132)
30	1000GENOMES	ss235274416	Jul 15, 2010 (132)
31	1000GENOMES	ss241961704	Jul 15, 2010 (132)
32	BL	ss254496880	May 09, 2011 (134)
33	GMI	ss280714784	May 04, 2012 (137)
34	PJP	ss290890263	May 09, 2011 (134)
35	ILLUMINA	ss480337811	May 04, 2012 (137)
36	ILLUMINA	ss480349394	May 04, 2012 (137)
37	ILLUMINA	ss481114852	Sep 08, 2015 (146)
38	ILLUMINA	ss484966522	May 04, 2012 (137)
39	ILLUMINA	ss537006311	Sep 08, 2015 (146)
40	TISHKOFF	ss562115108	Apr 25, 2013 (138)
41	SSMP	ss657122840	Apr 25, 2013 (138)
42	ILLUMINA	ss778845475	Sep 08, 2015 (146)
43	ILLUMINA	ss782929574	Sep 08, 2015 (146)
44	ILLUMINA	ss783892402	Sep 08, 2015 (146)
45	ILLUMINA	ss832184928	Sep 08, 2015 (146)
46	ILLUMINA	ss834306071	Sep 08, 2015 (146)
47	EVA-GONL	ss987754064	Aug 21, 2014 (142)
48	JMKIDD_LAB	ss1077180179	Aug 21, 2014 (142)
49	1000GENOMES	ss1338437791	Aug 21, 2014 (142)
50	DDI	ss1426397449	Apr 01, 2015 (144)
51	EVA_GENOME_DK	ss1575269225	Apr 01, 2015 (144)
52	EVA_DECODE	ss1597426940	Apr 01, 2015 (144)
53	EVA_UK10K_ALSPAC	ss1625093712	Apr 01, 2015 (144)
54	EVA_UK10K_TWINSUK	ss1668087745	Apr 01, 2015 (144)
55	EVA_MGP	ss1711264000	Apr 01, 2015 (144)
56	EVA_SVP	ss1713198903	Apr 01, 2015 (144)
57	ILLUMINA	ss1751985426	Sep 08, 2015 (146)
58	HAMMER_LAB	ss1806500675	Sep 08, 2015 (146)
59	WEILL_CORNELL_DGM	ss1931122417	Feb 12, 2016 (147)
60	GENOMED	ss1967189125	Jul 19, 2016 (147)
61	JJLAB	ss2026288933	Sep 14, 2016 (149)
62	USC_VALOUEV	ss2154564419	Dec 20, 2016 (150)
63	HUMAN_LONGEVITY	ss2176764604	Dec 20, 2016 (150)
64	SYSTEMSBIOZJU	ss2627613628	Nov 08, 2017 (151)
65	ILLUMINA	ss2632742267	Nov 08, 2017 (151)
66	ILLUMINA	ss2635017553	Nov 08, 2017 (151)
67	GRF	ss2698815732	Nov 08, 2017 (151)
68	GNOMAD	ss2891603029	Nov 08, 2017 (151)
69	SWEGEN	ss3006889212	Nov 08, 2017 (151)
70	BIOINF_KMB_FNS_UNIBA	ss3026934132	Nov 08, 2017 (151)
71	CSHL	ss3349240398	Nov 08, 2017 (151)
72	ILLUMINA	ss3626499380	Oct 12, 2018 (152)
73	ILLUMINA	ss3630766073	Oct 12, 2018 (152)
74	ILLUMINA	ss3632958414	Oct 12, 2018 (152)
75	ILLUMINA	ss3633655994	Oct 12, 2018 (152)
76	ILLUMINA	ss3634415178	Oct 12, 2018 (152)
77	ILLUMINA	ss3635348301	Oct 12, 2018 (152)
78	ILLUMINA	ss3636098983	Oct 12, 2018 (152)
79	ILLUMINA	ss3637099004	Oct 12, 2018 (152)
80	ILLUMINA	ss3637864245	Oct 12, 2018 (152)
81	ILLUMINA	ss3640122519	Oct 12, 2018 (152)
82	ILLUMINA	ss3642866498	Oct 12, 2018 (152)
83	OMUKHERJEE_ADBS	ss3646412916	Oct 12, 2018 (152)
84	EGCUT_WGS	ss3674298902	Jul 13, 2019 (153)
85	EVA_DECODE	ss3690369175	Jul 13, 2019 (153)
86	ACPOP	ss3737543669	Jul 13, 2019 (153)
87	ILLUMINA	ss3744716151	Jul 13, 2019 (153)
88	EVA	ss3748411718	Jul 13, 2019 (153)
89	ILLUMINA	ss3772216534	Jul 13, 2019 (153)
90	PACBIO	ss3786744090	Jul 13, 2019 (153)
91	PACBIO	ss3791913861	Jul 13, 2019 (153)
92	PACBIO	ss3796795969	Jul 13, 2019 (153)
93	KHV_HUMAN_GENOMES	ss3813779171	Jul 13, 2019 (153)
94	EVA	ss3832252676	Apr 26, 2020 (154)
95	EVA	ss3839666989	Apr 26, 2020 (154)
96	EVA	ss3845140409	Apr 26, 2020 (154)
97	SGDP_PRJ	ss3874732850	Apr 26, 2020 (154)
98	KRGDB	ss3922848586	Apr 26, 2020 (154)
99	KOGIC	ss3968369929	Apr 26, 2020 (154)
100	FSA-LAB	ss3983982132	Apr 26, 2021 (155)
101	EVA	ss3986491373	Apr 26, 2021 (155)
102	EVA	ss4017498775	Apr 26, 2021 (155)
103	TOPMED	ss4861004502	Apr 26, 2021 (155)
104	TOMMO_GENOMICS	ss5198760854	Apr 26, 2021 (155)
105	EVA	ss5237209779	Apr 26, 2021 (155)
106	1000G_HIGH_COVERAGE	ss5284927522	Oct 16, 2022 (156)
107	EVA	ss5315491051	Oct 16, 2022 (156)
108	EVA	ss5395033366	Oct 16, 2022 (156)
109	HUGCELL_USP	ss5480403633	Oct 16, 2022 (156)
110	EVA	ss5510113075	Oct 16, 2022 (156)
111	1000G_HIGH_COVERAGE	ss5579322425	Oct 16, 2022 (156)
112	EVA	ss5623949895	Oct 16, 2022 (156)
113	SANFORD_IMAGENETICS	ss5649795072	Oct 16, 2022 (156)
114	TOMMO_GENOMICS	ss5744916717	Oct 16, 2022 (156)
115	EVA	ss5800061948	Oct 16, 2022 (156)
116	EVA	ss5800160749	Oct 16, 2022 (156)
117	YY_MCH	ss5811752695	Oct 16, 2022 (156)
118	EVA	ss5824743663	Oct 16, 2022 (156)
119	EVA	ss5846863769	Oct 16, 2022 (156)
120	EVA	ss5848303090	Oct 16, 2022 (156)
121	EVA	ss5849676015	Oct 16, 2022 (156)
122	EVA	ss5941075900	Oct 16, 2022 (156)
123	EVA	ss5980628627	Oct 16, 2022 (156)
124	EVA	ss5981261887	Oct 16, 2022 (156)
125	1000Genomes	NC_000010.10 - 89653686	Oct 12, 2018 (152)
126	1000Genomes_30x	NC_000010.11 - 87893929	Oct 16, 2022 (156)
127	The Avon Longitudinal Study of Parents and Children	NC_000010.10 - 89653686	Oct 12, 2018 (152)
128	Genetic variation in the Estonian population	NC_000010.10 - 89653686	Oct 12, 2018 (152)
129	The Danish reference pan genome	NC_000010.10 - 89653686	Apr 26, 2020 (154)
130	gnomAD - Genomes	NC_000010.11 - 87893929	Apr 26, 2021 (155)
131	Genome of the Netherlands Release 5	NC_000010.10 - 89653686	Apr 26, 2020 (154)
132	HapMap	NC_000010.11 - 87893929	Apr 26, 2020 (154)
133	KOREAN population from KRGDB	NC_000010.10 - 89653686	Apr 26, 2020 (154)
134	Korean Genome Project	NC_000010.11 - 87893929	Apr 26, 2020 (154)
135	Medical Genome Project healthy controls from Spanish population	NC_000010.10 - 89653686	Apr 26, 2020 (154)
136	Northern Sweden	NC_000010.10 - 89653686	Jul 13, 2019 (153)
137	Qatari	NC_000010.10 - 89653686	Apr 26, 2020 (154)
138	SGDP_PRJ	NC_000010.10 - 89653686	Apr 26, 2020 (154)
139	Siberian	NC_000010.10 - 89653686	Apr 26, 2020 (154)
140	8.3KJPN	NC_000010.10 - 89653686	Apr 26, 2021 (155)
141	14KJPN	NC_000010.11 - 87893929	Oct 16, 2022 (156)
142	TopMed	NC_000010.11 - 87893929	Apr 26, 2021 (155)
143	UK 10K study - Twins	NC_000010.10 - 89653686	Oct 12, 2018 (152)
144	A Vietnamese Genetic Variation Database	NC_000010.10 - 89653686	Jul 13, 2019 (153)
145	ALFA	NC_000010.11 - 87893929	Apr 26, 2021 (155)
146	ClinVar	RCV001653874.5	Oct 16, 2022 (156)

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID	History Updated (Build)
rs60869655	May 26, 2008 (130)
rs386548647	Aug 21, 2014 (142)

Added to this RefSNP Cluster:

Submission IDs	Observation SPDI	Canonical SPDI	Source RSIDs
30025980, ss3922848586	NC_000010.10:89653685:A:C	NC_000010.11:87893928:A:C	(self)
ss88301756, ss109634293, ss113609472, ss119257624, ss160474841, ss170681972, ss174678632, ss201828161, ss207346372, ss254496880, ss280714784, ss290890263, ss480337811, ss1597426940, ss1713198903, ss2635017553, ss3642866498	NC_000010.9:89643665:A:G	NC_000010.11:87893928:A:G	(self)
50862130, 28232709, 20037150, 2263849, 12590062, 30025980, 379760, 10828534, 13164347, 26749830, 7080773, 56730161, 28232709, 6269937, ss224860360, ss235274416, ss241961704, ss480349394, ss481114852, ss484966522, ss537006311, ss562115108, ss657122840, ss778845475, ss782929574, ss783892402, ss832184928, ss834306071, ss987754064, ss1077180179, ss1338437791, ss1426397449, ss1575269225, ss1625093712, ss1668087745, ss1711264000, ss1751985426, ss1806500675, ss1931122417, ss1967189125, ss2026288933, ss2154564419, ss2627613628, ss2632742267, ss2698815732, ss2891603029, ss3006889212, ss3349240398, ss3626499380, ss3630766073, ss3632958414, ss3633655994, ss3634415178, ss3635348301, ss3636098983, ss3637099004, ss3637864245, ss3640122519, ss3646412916, ss3674298902, ss3737543669, ss3744716151, ss3748411718, ss3772216534, ss3786744090, ss3791913861, ss3796795969, ss3832252676, ss3839666989, ss3874732850, ss3922848586, ss3983982132, ss3986491373, ss4017498775, ss5198760854, ss5315491051, ss5395033366, ss5510113075, ss5623949895, ss5649795072, ss5800061948, ss5800160749, ss5824743663, ss5848303090, ss5941075900, ss5980628627, ss5981261887	NC_000010.10:89653685:A:G	NC_000010.11:87893928:A:G	(self)
RCV001653874.5, 66848360, 359387886, 457822, 24747930, 78753821, 76550157, 10734338171, ss2176764604, ss3026934132, ss3690369175, ss3813779171, ss3845140409, ss3968369929, ss4861004502, ss5237209779, ss5284927522, ss5480403633, ss5579322425, ss5744916717, ss5811752695, ss5846863769, ss5849676015	NC_000010.11:87893928:A:G	NC_000010.11:87893928:A:G	(self)
ss12083906	NT_030059.10:8092233:A:G	NC_000010.11:87893928:A:G	(self)
ss16083263	NT_030059.11:8402201:A:G	NC_000010.11:87893928:A:G	(self)
ss76890114	NT_030059.12:8402201:A:G	NC_000010.11:87893928:A:G	(self)
ss2787378, ss3237058, ss3464781, ss23639050, ss38349717, ss38636209, ss48296530, ss65758116, ss69086718, ss74863338, ss80745056, ss95216435, ss102645205, ss102899696, ss155345362, ss172978187	NT_030059.13:40458149:A:G	NC_000010.11:87893928:A:G	(self)
30025980, ss3922848586	NC_000010.10:89653685:A:T	NC_000010.11:87893928:A:T	(self)

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

8 citations for rs1903858

PMID	Title	Author	Year	Journal
18805939	Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.	Tempfer CB et al.	2009	Human reproduction update
21633361	Germ-line sequence variants of PTEN do not have an important role in hereditary and non-hereditary prostate cancer susceptibility.	Xie CC et al.	2011	Journal of human genetics
22562547	Genetic variation in genes involved in hormones, inflammation and energetic factors and breast cancer risk in an admixed population.	Slattery ML et al.	2012	Carcinogenesis
24959314	Influence of CHIEF pathway genes on gene expression: a pathway approach to functionality.	Slattery ML et al.	2014	International journal of molecular epidemiology and genetics
26082156	No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population.	Zou W et al.	2015	Reproductive biology and endocrinology
27187382	Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects.	Granata S et al.	2016	International journal of molecular sciences
32537792	Association of phosphatase and tension homologue deleted on chromosome ten polymorphism rs1903858, but not serum levels with the risk of non-small-cell lung cancer: A case-control study.	Liang Z et al.	2020	Journal of clinical laboratory analysis
32583210	Association of genetic variations in phosphatase and tensin homolog (PTEN) gene with polycystic ovary syndrome in South Indian women: a case control study.	Siddamalla S et al.	2020	Archives of gynecology and obstetrics

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

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Genomic regions, transcripts, and products
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NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

Reference SNP (rs) Report

rs1903858