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    D15 flap endonuclease [ Escherichia phage T5 ]

    Gene ID: 2777611, updated on 21-Jun-2023

    Summary

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    Gene symbol
    D15
    Gene description
    flap endonuclease
    Locus tag
    T5.130
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia phage T5 (nat-host: Escherichia coli)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Demerecviridae; Markadamsvirinae; Tequintavirus
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    Genomic context

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    Sequence:
    NC_005859.1 (80077..80968)

    NC_005859.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene single strand DNA binding protein Neighboring gene putative recombination endonuclease, subunit D12 Neighboring gene putative recombination endonuclease, subunit D13 Neighboring gene RusA-like Holliday junction resolvase Neighboring gene hypothetical protein Neighboring gene dUTPase Neighboring gene hypothetical protein Neighboring gene tail fiber protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_005859.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Direct observation of DNA threading in flap endonuclease complexes. AlMalki FA, et al. Nat Struct Mol Biol, 2016 Jul. PMID 27273516, Free PMC Article
    2. The deoxyribonuclease induced after infection of Escherichia coli by bacteriophage T5. II. Role of the enzyme in replication of the pahge deoxyribonucleic acid. Frenkel GD, et al. J Biol Chem, 1971 Aug 10. PMID 4934992
    3. A single-strand specific endonuclease activity copurifies with overexpressed T5 D15 exonuclease. Sayers JR, et al. Nucleic Acids Res, 1991 Aug 11. PMID 1651477, Free PMC Article
    4. Properties of overexpressed phage T5 D15 exonuclease. Similarities with Escherichia coli DNA polymerase I 5'-3' exonuclease. Sayers JR, et al. J Biol Chem, 1990 Oct 25. PMID 2211703
    5. DNA filter retention assay for exonuclease activities. Application to the analysis of processivity of phage T5 induced 5'-exonuclease. Joannes M, et al. Biochemistry, 1985 Dec 31. PMID 3004572

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct observation of DNA threading in flap endonuclease complexes with DNA has been reported.
      Title: Direct observation of DNA threading in flap endonuclease complexes.
    Submit: New GeneRIF Correction

    General protein information

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    Preferred Names
    flap endonuclease
    YP_006958.1
    • flap endonucleases, or 5'-nucleases, are involved in DNA replication and repair; they possess both 5'-exonucleolytic activity and the ability to cleave bifurcated, or branched DNA, in an endonucleolytic structure-specific manner; 5'-nuclease D15 is also required for late transcription; matches to InterPro family IPR002421 and InterPro domains IPR000513 and IPR008918

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_005859.1 Reference assembly

      Range
      80077..80968
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_006958.1 flap endonuclease [Escherichia phage T5]

      See identical proteins and their annotated locations for YP_006958.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P06229, Q5DMH3, Q66LT5
      Conserved Domains (1) summary
      smart00475
      Location:20 → 274
      53EXOc; 5'-3' exonuclease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    1203256A.1
    1UT5_A.1
    1UT5_B.1
    1UT8_A.1
    1UT8_B.1
    P06229.3

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