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    AKR1C5 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) [ Oryctolagus cuniculus (rabbit) ]

    Gene ID: 100009071, updated on 19-Feb-2025

    Summary

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    Gene symbol
    AKR1C5
    Gene description
    aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oryctolagus cuniculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
    Also known as
    AKR1C1
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    Genomic context

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    See AKR1C5 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_11 current mOryCun1.1 (GCF_964237555.1) 13 NC_091444.1 (78163186..78181852, complement)
    RS_2023_02 previous assembly UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259195.1 (912718..949827, complement)

    Chromosome 13 - NC_091444.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127487868 Neighboring gene uncharacterized LOC103345162 Neighboring gene putative aldo-keto reductase family 1 member C8 Neighboring gene uncharacterized LOC127487867

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. Couture JF, et al. J Mol Biol, 2004 May 21. PMID 15123423
    2. Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity. Wintergalen N, et al. Eur J Biochem, 1995 Nov 15. PMID 8529651
    3. Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity. Lacy WR, et al. Mol Endocrinol, 1993 Jan. PMID 8446108
    4. Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity. Lacy W, et al. Mol Endocrinol, 1993 Sep. PMID 8247025
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aldose reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables androsterone dehydrogenase [NAD(P)+] activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables bile acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ketosteroid monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in daunorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in doxorubicin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in progesterone metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in prostaglandin metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prostaglandin-E(2) 9-reductase
    Names
    20-alpha-HSD
    20-alpha-hydroxysteroid dehydrogenase
    NP_001075719.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082250.1 → NP_001075719.1  prostaglandin-E(2) 9-reductase

      See identical proteins and their annotated locations for NP_001075719.1

      Status: PROVISIONAL

      Source sequence(s)
      L17006
      UniProtKB/Swiss-Prot
      P80508
      UniProtKB/TrEMBL
      A0A5F9CBR3
      Conserved Domains (1) summary
      cd19108
      Location:6 → 308
      AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_964237555.1-RS_2024_11

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mOryCun1.1

    Genomic

    1. NC_091444.1 Reference mOryCun1.1

      Range
      78163186..78181852 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P80508.1 GenPept UniProtKB/Swiss-Prot:P80508

    Gene LinkOut

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