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Select item 118177221.

ChREBP-mediated up-regulation of Them1 coordinates thermogenesis with glycolysis and lipogenesis in response to chronic stress

Xu Xu, Arturo Mendoza, Christopher S. Krumm, Shi Su, Mariana Acuña, Curtis J. Bare, Corey D. Holman, Marissa Cortopassi, Hayley T. Nicholls, Vincent Dartigue, Anthony N. Hollenberg, Ann-Hwee Lee, Susan J. Hagen, David E. Cohen

Sci Signal. Author manuscript; available in PMC 2025 Feb 12.

Published in final edited form as: Sci Signal. 2024 Dec 3; 17(865): eadk7971. Published online 2024 Dec 3. doi: 10.1126/scisignal.adk7971

PMCID:: PMC11817722

Article PDF–2.0M

Select item 118269252.

Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer

Ricardo A. Cordova, Noah R. Sommers, Andrew S. Law, Angela J. Klunk, Katherine, E. Brady, David W. Goodrich, Tracy G. Anthony, Jeffrey J. Brault, Roberto Pili, Ronald C. Wek, Kirk A. Staschke

Sci Signal. Author manuscript; available in PMC 2025 Feb 14.

Published in final edited form as: Sci Signal. 2024 Nov 26; 17(864): eadp1375. Published online 2024 Nov 26. doi: 10.1126/scisignal.adp1375

PMCID:: PMC11826925

Article PDF–3.7M

Select item 116003383.

Amyloid-β oligomers trigger sex-dependent inhibition of GIRK channel activity in hippocampal neurons in mice

Haichang Luo, Ezequiel Marron Fernandez de Velasco, Benjamin Gansemer, McKinzie Frederick, Carolina Aguado, Rafael Luján, Stanley A. Thayer, Kevin Wickman

Sci Signal. Author manuscript; available in PMC 2024 Nov 27.

Published in final edited form as: Sci Signal. 2024 Oct; 17(856): eado4132. Published online 2024 Oct 1. doi: 10.1126/scisignal.ado4132

PMCID:: PMC11600338

Article PDF–1.9M

Select item 114877634.

ProNGF elicits retrograde axonal degeneration of basal forebrain neurons through p75^NTR and induction of amyloid precursor protein

Srestha Dasgupta, Mansi A. Pandya, Juan P. Zanin, Tong Liu, Qian Sun, Hong Li, Wilma J. Friedman

Sci Signal. Author manuscript; available in PMC 2024 Oct 18.

Published in final edited form as: Sci Signal. 2024 Sep 24; 17(855): eadn2616. Published online 2024 Sep 24. doi: 10.1126/scisignal.adn2616

PMCID:: PMC11487763

Article PDF–3.9M

Select item 114603105.

Delivery of US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes

Jamil Mahmud, Brittany W. Geiler, Juthi Biswas, Michael J. Miller, Julia E. Myers, Stephen M. Matthews, Amanda B. Wass, Christine M. O’Connor, Gary C. Chan

Sci Signal. Author manuscript; available in PMC 2024 Oct 8.

Published in final edited form as: Sci Signal. 2024 Aug 27; 17(851): eadn8727. Published online 2024 Aug 27. doi: 10.1126/scisignal.adn8727

PMCID:: PMC11460310

Article PDF–1.9M

Select item 114431826.

Phosphorylation patterns on the AT1R C-terminal tail specify distinct downstream signaling pathways

Clarice Gareri, Conrad T. Pfeiffer, Xue Jiang, Joao A. Paulo, Steven P. Gygi, Uyen Pham, Anand Chundi, Laura M. Wingler, Dean P. Staus, Tomasz Maciej Stepniewski, Jana Selent, Emilio Y. Lucero, Alyssa Grogan, Sudarshan Rajagopal, Howard A. Rockman

Sci Signal. Author manuscript; available in PMC 2024 Oct 1.

Published in final edited form as: Sci Signal. 2024 Aug 13; 17(849): eadk5736. Published online 2024 Aug 13. doi: 10.1126/scisignal.adk5736

PMCID:: PMC11443182

Article PDF–3.1M

Select item 113896477.

Generation of antitumor chimeric antigen receptors incorporating T cell signaling motifs

Lakshmi Balagopalan, Taylor Moreno, Haiying Qin, Benjamin C. Angeles, Taisuke Kondo, Jason Yi, Katherine M. McIntire, Neriah Alvinez, Sandeep Pallikkuth, Mariah E. Lee, Hidehiro Yamane, Andy D. Tran, Philippe Youkharibache, Raul E. Cachau, Naomi Taylor, Lawrence E. Samelson

Sci Signal. Author manuscript; available in PMC 2024 Sep 11.

Published in final edited form as: Sci Signal. 2024 Jul 23; 17(846): eadp8569. Published online 2024 Jul 23. doi: 10.1126/scisignal.adp8569

PMCID:: PMC11389647

Article PDF–2.7M

Select item 112389028.

Protein phosphatase 6 activates NF-κB to confer sensitivity to MAPK pathway inhibitors in KRAS and BRAF mutant cancer cells

Haibo Zhang, Abigail Read, Christophe Cataisson, Howard H. Yang, Wei-Chun Lee, Benjamin E. Turk, Stuart H. Yuspa, Ji Luo

Sci Signal. Author manuscript; available in PMC 2024 Jul 11.

Published in final edited form as: Sci Signal. 2024 May 14; 17(836): eadd5073. Published online 2024 May 14. doi: 10.1126/scisignal.add5073

PMCID:: PMC11238902

Article PDF–3.0M

Select item 112235189.

Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice

Xin Shi, Xiao-zhong Zhou, Gang Chen, Wei-feng Luo, Chengyu Zhou, Tian-ju He, Mandar T. Naik, Qin Jiang, John Marshall, Cong Cao

Sci Signal. Author manuscript; available in PMC 2024 Jul 4.

Published in final edited form as: Sci Signal. 2024 Apr 30; 17(834): eadn4556. Published online 2024 Apr 30. doi: 10.1126/scisignal.adn4556

PMCID:: PMC11223518

Article PDF–2.8M

Select item 1118262910.

Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection

Wenjiao Wu, Vinothini Arunagiri, Hanh Chi Do-Umehara, Cong Chen, Shuyin Gu, Indrani Biswas, Karen M. Ridge, G. R. Scott Budinger, Shuwen Liu, Jing Liu

Sci Signal. Author manuscript; available in PMC 2024 Jun 17.

Published in final edited form as: Sci Signal. 2024 Apr 9; 17(831): eadg7867. Published online 2024 Apr 9. doi: 10.1126/scisignal.adg7867

PMCID:: PMC11182629

Article PDF–2.0M

Select item 1116187111.

Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition

Caroline Fidalgo Ribeiro, Silvia Rodrigues, Debora Campanella Bastos, Giuseppe Nicolò Fanelli, Hubert Pakula, Marco Foiani, Giorgia Zadra, Massimo Loda

Sci Signal. Author manuscript; available in PMC 2024 Jun 8.

Published in final edited form as: Sci Signal. 2024 Apr 9; 17(831): eadh1922. Published online 2024 Apr 9. doi: 10.1126/scisignal.adh1922

PMCID:: PMC11161871

Article PDF–2.6M

Select item 1102207812.

Exercise-induced BDNF promotes PPARδ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery

Wing Suen Chan, Chun Fai Ng, Brian Pak Shing Pang, Miaojia Hang, Margaret Chui Ling Tse, Elsie Chit Yu Iu, Xin Ci Ooi, Xiuying Yang, Jason K. Kim, Chi Wai Lee, Chi Bun Chan

Sci Signal. Author manuscript; available in PMC 2024 Apr 17.

Published in final edited form as: Sci Signal. 2024 Mar 19; 17(828): eadh2783. Published online 2024 Mar 19. doi: 10.1126/scisignal.adh2783

PMCID:: PMC11022078

Article PDF–2.7M

Select item 761576813.

CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans

Carl W. White, Simon Platt, Laura E. Kilpatrick, Natasha Dale, Rekhati S. Abhayawardana, Sebastian Dekkers, Nicholas D Kindon, Barrie Kellam, Michael J Stocks, Kevin D. G. Pfleger, Stephen J. Hill

Sci Signal. Author manuscript; available in PMC 2024 Mar 26.

Published in final edited form as: Sci Signal. 2024 Mar 19; 17(828): eabl3758. Published online 2024 Mar 19. doi: 10.1126/scisignal.abl3758

PMCID:: PMC7615768

Article PDF–2.2M

Select item 1092703014.

GPCR kinases differentially modulate biased signaling downstream of CXCR3 depending on their subcellular localization

Julia Gardner, Dylan Scott Eiger, Chloe Hicks, Issac Choi, Uyen Pham, Anand Chundi, Ojas Namjoshi, Sudarshan Rajagopal

Sci Signal. Author manuscript; available in PMC 2024 Mar 11.

Published in final edited form as: Sci Signal. 2024 Feb 13; 17(823): eadd9139. Published online 2024 Feb 13. doi: 10.1126/scisignal.add9139

PMCID:: PMC10927030

Article PDF–2.4M

Select item 1089790715.

Cbl-b mitigates the responsiveness of naive CD8⁺ T cells that experience extensive tonic T cell receptor signaling

Joel Eggert, Wendy M. Zinzow-Kramer, Yuesong Hu, Elizabeth M. Kolawole, Yuan-Li Tsai, Arthur Weiss, Brian D. Evavold, Khalid Salaita, Christopher D. Scharer, Byron B. Au-Yeung

Sci Signal. Author manuscript; available in PMC 2024 Mar 6.

Published in final edited form as: Sci Signal. 2024 Feb 6; 17(822): eadh0439. Published online 2024 Feb 6. doi: 10.1126/scisignal.adh0439

PMCID:: PMC10897907

Article PDF–2.0M

Select item 1091650116.

A plasma membrane–associated form of the androgen receptor enhances nuclear androgen signaling in osteoblasts and prostate cancer cells

Hema Kalyanaraman, Darren E. Casteel, Shyamsundar Pal China, Shunhui Zhuang, Gerry R. Boss, Renate B. Pilz

Sci Signal. Author manuscript; available in PMC 2024 Mar 6.

Published in final edited form as: Sci Signal. 2024 Jan 30; 17(821): eadi7861. Published online 2024 Jan 30. doi: 10.1126/scisignal.adi7861

PMCID:: PMC10916501

Article PDF–4.2M

Select item 1111119317.

A non-canonical IRAK4-IRAK1 pathway counters DNA damage-induced apoptosis independently of TLR/IL-1R signaling

Yuanyuan Li, Richa B. Shah, Samanta Sarti, Alicia L. Belcher, Brian J. Lee, Andrej Gorbatenko, Francesca Nemati, Honglin Yu, Zoe Stanley, Mahbuba Rahman, Zhengping Shao, Jose M. Silva, Shan Zha, Samuel Sidi

Sci Signal. Author manuscript; available in PMC 2024 Dec 19.

Published in final edited form as: Sci Signal. 2023 Dec 19; 16(816): eadh3449. Published online 2023 Dec 19. doi: 10.1126/scisignal.adh3449

PMCID:: PMC11111193

Article PDF–2.0M

Select item 1072684818.

Impaired intracellular Ca²⁺ signaling contributes to age-related cerebral small vessel disease in Col4a1 mutant mice

Evan Yamasaki, Pratish Thakore, Sher Ali, Alfredo Sanchez Solano, Xiaowei Wang, Xiao Gao, Cassandre Labelle-Dumais, Myriam M. Chaumeil, Douglas B. Gould, Scott Earley

Sci Signal. Author manuscript; available in PMC 2024 May 14.

Published in final edited form as: Sci Signal. 2023 Nov 14; 16(811): eadi3966. Published online 2023 Nov 14. doi: 10.1126/scisignal.adi3966

PMCID:: PMC10726848

Article PDF–1.2M

Select item 1069492219.

Vasodilators activate the anion channel TMEM16A in endothelial cells to reduce blood pressure

Alejandro Mata-Daboin, Tessa A. C. Garrud, Carlos Fernandez-Pena, Dieniffer Peixoto-Neves, M. Dennis Leo, Angelica K. Bernardelli, Purnima Singh, Kafait U. Malik, Jonathan H. Jaggar

Sci Signal. Author manuscript; available in PMC 2024 Nov 14.

Published in final edited form as: Sci Signal. 2023 Nov 14; 16(811): eadh9399. Published online 2023 Nov 14. doi: 10.1126/scisignal.adh9399